64 Results for "

isolated tissue

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165

JC-1 Mitochondrial Membrane Potential Assay Kit

165 Publications Verification

Cat. No.: HY-K0601

MCE JC-1 Mitochondrial Membrane Potential Assay Kit uses JC-1 to detect the mitochondrial membrane potential in variety of cell types, as well as intact tissues and isolated mitochondria.

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Pyrroloquinoline quinone

9 Cited Publications

Cat. No.: HY-100196

CAS No.: 72909-34-3

Purity: 99.82%

Synonyms: PQQ; Methoxatin

Category:

Quinones Microorganisms Animals Benzene Quinones Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite

Pyrroloquinoline quinone (PQQ), a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone is an essential nutrient for mammals and is important for immune function .

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Pyrroloquinoline quinone disodium salt

9 Cited Publications

Cat. No.: HY-100196A

CAS No.: 122628-50-6

Purity: ≥98.0%

Synonyms: PQQ disodium salt; Methoxatin disodium salt

Category:

Quinones Microorganisms Benzene Quinones Endogenous metabolite Disease Research Fields Inflammation/Immunology

Target:

Endogenous Metabolite

Pyrroloquinoline quinone disodium salt, a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone disodium salt is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone disodium salt is an essential nutrient for mammals and is important for immune function .

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Phentolamine hydrochloride

8 Cited Publications

Cat. No.: HY-12717A

CAS No.: 73-05-2

Purity: 99.87%

Target:

Adrenergic Receptor

Research Areas:

Cardiovascular Disease Endocrinology

Phentolamine hydrochloride is an orally active, selective α1 and α2 Adrenergic receptor antagonist. Phentolamine hydrochloride antagonizes the vasodilatory effect of Cromakalim (HY-110011) on isolated circumflex coronary artery segments in dogs. Phentolamine hydrochloride reduces systemic vascular resistance and increases cardiac output. Phentolamine hydrochloride improves erectile dysfunction. Phentolamine hydrochloride can be used for the research of erectile dysfunction .

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β-Anhydroicaritin

3 Cited Publications

Cat. No.: HY-N1940

CAS No.: 38226-86-7

Synonyms: Cycloicaritin

Category:

Flavonols Flavonoids Plants Burseraceae Disease Research Fields Inflammation/Immunology Boswellia carterii

Target:

Interleukin Related TNF Receptor MMP

β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties . β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

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Dihydroconiferyl alcohol

1 Cited Publications

Cat. No.: HY-W016393

CAS No.: 2305-13-7

Category:

other families Monophenols Other Diseases Phenols Plants Disease Research Fields

Target:

Endogenous Metabolite

Dihydroconiferyl alcohol is a cell division factor. Dihydroconiferyl alcohol can be isolated from the American sycamore (Acer pseudoplatanus L.). Dihydroconiferyl alcohol inhibits the degradation of Indole-3-acetic acid (HY-18569). Dihydroconiferyl alcohol can stimulate the growth of soybean and tobacco callus tissue and synergistically enhance Indole-3-acetic acid-induced hypocotyl elongation in cucumber. Dihydroconiferyl alcohol can be used in the research of plant growth regulation .

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Isorhamnetin 3-O-galactoside

1 Cited Publications

Cat. No.: HY-N2082

CAS No.: 6743-92-6

Synonyms: Cacticin

Category:

Cardiovascular Disease Flavonols Flavonoids Typhaceae Typha angustifolia L. Phenols Polyphenols Plants Disease Research Fields

Target:

Thrombin COX ERK JNK Factor Xa

Isorhamnetin 3-O-galactoside (Cacticin) is a flavonoid glycoside that can be isolated from Oenanthe javanica, with antithrombotic and profibrinolytic activities. Isorhamnetin 3-O-galactoside inhibits the activities of thrombin and factor Xa (FXa) and reduces thrombin-catalyzed fibrin polymerization maximum rate. Isorhamnetin 3-O-galactoside suppresses TNF-α-induced PAI-1 secretion, decreases the PAI-1/tissue-type plasminogen activator (t-PA) ratio, and inhibits FXa production and FVa/FXa-mediated thrombin generation. Isorhamnetin 3-O-galactoside exerts protective effects against Carbon tetrachloride (CCl4) (HY-Y0298)-induced hepatic injury in mice. Isorhamnetin 3-O-galactoside can be used for the study of liver injury-related diseases and thrombotic vascular diseases .

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7-Amino-4-methylcoumarin

Cat. No.: HY-D0027

CAS No.: 26093-31-2

Synonyms: Coumarin 120; AMC

7-Amino-4-methylcoumarin belongs to the coumarin class, can be isolated from the endophytic fungus Xylaria sp. and has a broad spectrum of antibacterial activity. 7-Amino-4-methylcoumarin is also commonly used as an important laser dye that emits in the blue region, capable of analyzing glycoprotein monosaccharides and N-linked oligosaccharides, and is also utilized in tissue pathology analysis, enzyme activity measurement, and copper ion detection. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively.

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Agar, microbiology tested, for cell culture (powder)

Cat. No.: HY-W134423

CAS No.: 9002-18-0

Agar, microbiology tested, for cell culture (powder) is a jelly like substance that contains agarose and agar gel. Agar, microbiology tested, for cell culture (powder) can be isolated from the cell walls of red algae species such as Gelidium and Gracilaria (Ogonori). The gelation and melting of Agar, microbiology tested, for cell culture (powder) is based on the hydrogen bridge (physical gels), so the gelation is reversible. Agar, microbiology tested, for cell culture (powder) is widely used in food additives, plant tissue culture, microorganisms culture media, fingerprint recognition, and medical fields .

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Indole-2-carbaldehyde

Cat. No.: HY-W015650

CAS No.: 19005-93-7

Indole-2-carbaldehyde is an indole derivative that can be used to reduce or remove localized fat deposits and/or tighten loose skin and soft tissues. Indole-2-carbaldehyde can be isolated from the fermentation broth of the coral symbiotic actinomycete Pseudonocardia sp. SCSIO 11457 and is used in cosmetic applications or pharmaceutical production .

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Glaucine

Cat. No.: HY-N3945

CAS No.: 475-81-0

Synonyms: O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396

Category:

Infection Alkaloids other families Plants Disease Research Fields Isoquinoline Alkaloids Inflammation/Immunology Glaucium flavum Papaveraceae

Target:

Phosphodiesterase (PDE) Calcium Channel MMP NF-κB

Glaucine (O,O-Dimethylisoboldine) is an alkaloid extracted from Glaucium flavum that possesses various activities, including cough relief, bronchodilation, anti-inflammatory effects, analgesia, antipyretic properties, and anticancer effects. Glaucine acts as a selective and orally active inhibitor of phosphodiesterase 4 (PDE4), with a K_i of 3.4 µM in human bronchial tissues and polymorphonuclear leukocytes. Glaucine induces relaxation of human isolated bronchi by antagonizing calcium channels. Additionally, Glaucine inhibits the activation of NF-κB, leading to a reduction in the expression of the MMP-9 gene, thereby suppressing the migration and invasion of breast cancer cells. Therefore, Glaucine holds potential for research in asthma and breast cancer .

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Licoricidin

Cat. No.: HY-N3387

CAS No.: 30508-27-1

Category:

Flavonoids Leguminosae Flavanols Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology

Target:

Apoptosis NF-κB Akt MMP

Licoricidin (LCD) is isolated from Glycyrrhiza uralensis Fisch, possesses anti-cancer activities. Licoricidin (LCD) inhibit SW480 cells (IC₅₀=7.2 μM) by inducing cycle arrest, apoptosis and autophagy, and is a potential chemopreventive or chemotherapeutic agent against colorectal cancer . Licoricidin (LCD) inhibits Lung Metastasis by inhibition of tumor angiogenesis and lymphangiogenesis as well as changes in the local microenvironment of tumor tissues the anticarcinogenic effect . Licoricidin enhanced gemcitabine-induced cytotoxicity in Osteosarcoma (OS) cells by inactivation of the Akt and NF-κB pathways in vitro and in vivo . Licoricidin blocks UVA-induced photoaging via ROS scavenging, limits the activity of MMP-1, it can be considered as an active ingredient in new topically applied anti-ageing formulations .

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Ozenoxacin

Cat. No.: HY-14957

CAS No.: 245765-41-7

Purity: 99.66%

Synonyms: T-3912

Target:

Bacterial Antibiotic

Research Areas:

Infection

Ozenoxacin is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections.

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Ilexoside D

Cat. No.: HY-N5037

CAS No.: 109008-27-7

Category:

Cardiovascular Disease Aquifoliaceae Triterpenes Terpenoids Plants Disease Research Fields Tabernaemontana elegans Stapf

Target:

Others

Ilexoside D is isolated from the roots of Ilex pubescens Hook. et Arn. Ilexoside D has the anti-tissue factor activity as well as the antithrombotic activity .

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Praeruptorin E

Cat. No.: HY-N6066

CAS No.: 78478-28-1

Category:

Cardiovascular Disease Salvia hypargeia Fisch. & C.A.Mey. Coumarins Phenylpropanoids Plants Umbelliferae Disease Research Fields

Target:

Calcium Channel NF-κB Pregnane X Receptor (PXR) Cytochrome P450 Interleukin Related

Praeruptorin E is an orally active pyranocoumarin compound. Praeruptorin E can be isolated from the dried roots of Peucedanum praeruptorum Dunn. Praeruptorin E reduces the expression of NF-κB. Praeruptorin E upregulates the expression of PXR and CYP3A4. Praeruptorin E inhibits Th2 cytokines, TNF-α, IL6, MPO, and blocks the Ca ²⁺ slow channel. Praeruptorin E promotes pulmonary tissue repair and relaxes porcine coronary artery strips. Praeruptorin E protects mice from lipopolysaccharide- and hydrochloric acid-induced acute lung injury. Praeruptorin E can be used in studies related to asthma and acute lung injury .

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Triptophenolide

Cat. No.: HY-N0475

CAS No.: 74285-86-2

Synonyms: Hypolide; (+)-Triptophenolide

Category:

Monophenols Terpenoids Other Diseases Celastraceae Phenols Diterpenoids Plants Tripterygium wilfordii Hook. f. Disease Research Fields

Target:

Androgen Receptor Pyroptosis Caspase Bcl-2 Family Apoptosis

Triptophenolide (Hypolide) is a colorless crystal isolated from the ethyl acetate extract of Tripterygium wilfordii. Triptophenolide is an orally active pan‑antagonist of the androgen receptor (AR) with an IC₅₀ of 467 nM against human wild‑type AR. Triptophenolide reduces AR expression, inhibits AR nuclear translocation, downregulates prostate‑specific antigen mRNA levels, and suppresses the growth of AR‑positive prostate cancer cells. Triptophenolide shows anti-tumor effects against breast cancer by inhibiting cell proliferation and migration, inducing G1-phase arrest and apoptosis, repressing xenograft tumor growth. Triptophenolide inhibits pyroptosis, alleviates tissue inflammation, and ameliorates synovial injury. Triptophenolide can be used for the study of prostate cancer, rheumatoid arthritis and breast cancer .

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Ginsenoside F4

Cat. No.: HY-N2503

CAS No.: 181225-33-2

Category:

Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Disease Research Fields Inflammation/Immunology Araliaceae

Target:

Apoptosis MMP

Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis . Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues .

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Tragacanth gum

Cat. No.: HY-W250121

CAS No.: 9000-65-1

Tragacanth gum is an orally active anionic composite polysaccharide and multifunctional biomaterial. Tragacanth gum exhibits biocompatibility, mucoadhesion and renoprotective effects, and effectively promotes wound closure and tissue healing. Tragacanth gum can be isolated from Astragalus gummifer. Tragacanth gum acts as an emulsifier and drug delivery carrier, and is also widely used in fields such as 3D scaffolds, tissue engineering and green nanoparticle preparation. High doses of Tragacanth gum may induce reversible forestomach squamous epithelial hyperplasia in mice, but show no mutagenic or carcinogenic activity. Tragacanth gum is commonly used in studies related to diseases including systemic candidiasis, rheumatoid arthritis and osteosarcoma .

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Physalin B

Cat. No.: HY-N7695

CAS No.: 23133-56-4

Category:

other families Ketones, Aldehydes, Acids Plants Disease Research Fields Cancer

Target:

Apoptosis NF-κB NOD-like Receptor (NLR) STAT PI3K Akt Hedgehog GSK-3 p38 MAPK ERK JNK Keap1-Nrf2 Reactive Oxygen Species (ROS) Autophagy

Physalin B is an orally active anti-inflammatory and anticancer agent. Physalin B can be isolated from Physalis alkekengi L. var. Franchetii. Physalin B inhibits the activation of the NF-κB, NLRP3 inflammasome, STAT3, PI3K/Akt and Hedgehog signaling pathways, regulates the phosphorylation levels of GSK-3β, p38 MAPK, ERK1/2 and JNK, and promotes the nuclear translocation of NRF2. Physalin B reduces the levels of pro-inflammatory cytokines and factors, induces mitochondrial reactive oxygen species (mito-ROS) production, Apoptosis, G2/M cell cycle arrest and incomplete Autophagy, alters cytoskeleton structure and alleviates oxidative stress. Physalin B reduces cancer cell viability, ameliorates liver and lung tissue damage and alleviates liver fibrosis. Physalin B can be used in research related to ulcerative colitis, breast cancer, acute lung injury, colon cancer, non-alcoholic steatohepatitis, liver fibrosis, lung cancer, pancreatic cancer, lymphoma, ovarian cancer, sarcoma and leukemia .

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Cirsimarin

Cat. No.: HY-N7272

CAS No.: 13020-19-4

Category:

Flavonoids Monophenols Leguminosae Flavones Metabolic Disease Phenols Abrus precatorius Linn. Plants Disease Research Fields

Target:

Phosphodiesterase (PDE)

Cirsimarin is a potent antilipogenic flavonoid isolated from Microtea debilis. Cirsimarin exerts potent antilipogenic effect and decreases adipose tissue deposition in mice. The lipolytic activity of Cirsimarin resulting from both its antagonist activity on adenosin A1 receptor and its inhibitory effect on phosphodiesterase .

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