73-05-2
Chemical Structure
Phentolamine hydrochloride
- CAS No.: 73-05-2
- Formula:C17H20ClN3O
- Molecular Weight:317.82
IUPAC Name: 3-(((4,5-dihydro-1H-imidazol-2-yl)methyl)(p-tolyl)amino)phenol hydrochloride
InChIKey: TUEJFGFQYKDAPM-UHFFFAOYSA-N
SMILES: OC1=CC=CC(N(CC2=NCCN2)C3=CC=C(C)C=C3)=C1.[H]Cl
Biological Activity: Phentolamine hydrochloride is an orally active, selective α1 and α2 Adrenergic receptor antagonist. Phentolamine hydrochloride antagonizes the vasodilatory effect of Cromakalim (HY-110011) on isolated circumflex coronary artery segments in dogs. Phentolamine hydrochloride reduces systemic vascular resistance and increases cardiac output. Phentolamine hydrochloride improves erectile dysfunction. Phentolamine hydrochloride can be used for the research of erectile dysfunction[1][2][3].
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Phentolamine hydrochloride | 99.91% | Phentolamine hydrochloride is an orally active, selective α1 and α2 Adrenergic receptor antagonist. Phentolamine hydrochloride antagonizes the vasodilatory effect of Cromakalim (HY-110011) on isolated circumflex coronary artery segments in dogs. Phentolamine hydrochloride reduces systemic vascular resistance and increases cardiac output. Phentolamine hydrochloride improves erectile dysfunction. Phentolamine hydrochloride can be used for the research of erectile dysfunction. | ||||||||||||||||||||
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Phentolamine hydrochloride (Standard) | ≥98% | Phentolamine (hydrochloride) (Standard) is the analytical standard of Phentolamine (hydrochloride). This product is intended for research and analytical applications. Phentolamine hydrochloride is an orally active adrenergic α receptor-blocking agent. | ||||||||||||||||||||
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Phentolamine-d4 hydrochloride | Phentolamine-d4 (hydrochloride) is the deuterium labeled Phentolamine hydrochloride. Phentolamine hydrochloride is a reversible, non-selective, and orally active blocker of α1 and α2 adrenergic receptor that expands blood vessels to reduce peripheral vascular resistance. Phentolamine hydrochloride can be used for the research of pheochromocytoma-related hypertension, heart failure and erectile dysfunction. | |||||||||||||||||||||
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- [1]. Goldstein I, et al. Oral phentolamine: an alpha-1, alpha-2 adrenergic antagonist for the treatment of erectile dysfunction. Int J Impot Res. 2000;12 Suppl 1:S75-S80. [Content Brief]
- [2]. Majid PA, et al. Phentolamine for vasodilator treatment of severe heart-failure. Lancet. 1971 Oct 2;2(7727):719-24. [Content Brief]
- [3]. McPherson GA, et al. Phentolamine and structurally related compounds selectively antagonize the vascular actions of the K+ channel opener, cromromakalim. Br J Pharmacol. 1989;97(3):941-949. [Content Brief]
