181225-33-2
Chemical Structure
Ginsenoside F4
- CAS No.: 181225-33-2
- Formula:C42H70O12
- Molecular Weight:767.00
IUPAC Name: (2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5S,6R)-2-(((3S,5R,6S,8R,9R,10R,12R,13R,14R,17S)-3,12-dihydroxy-4,4,8,10,14-pentamethyl-17-((E)-6-methylhepta-2,5-dien-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-6-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyra
InChIKey: QOMBXPYXWGTFNR-PWAOTOFHSA-N
SMILES: C[C@]12[C@]3([C@@]([C@H](O)C[C@]1([H])[C@@]4([C@@](C(C)([C@@H](O)CC4)C)([H])[C@@H](O[C@@]5([H])[C@@H]([C@H]([C@H](O)[C@@H](CO)O5)O)O[C@@]6([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O6)O)O)C2)C)([H])[C@@H](/C(C)=C/C/C=C(C)/C)CC3)C
Biological Activity: Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis[1]. Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ginsenoside F4 | 98.54% | Ginsenoside F4 (GF4), ginseng saponinis, isolated from notoginseng or red ginseng. Ginsenoside F4 (GF4) has inhibitory effect on human lymphocytoma JK cell by inducing its apoptosis. Ginsenoside F4 (GF4) inhibits matrix metalloproteinase 13 (MMP 13) expression in IL-1β-treated chondrocytes and blocks cartilage breakdown in rabbit cartilage tissue culture, shows therapeutic potential for preventing cartilage collagen matrix breakdown in diseased tissues. | ||||||||||||||||||||
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Similarity Score 1.00
HY-N6580Ginsenoside Rg4 -
Similarity Score 0.89
HY-N0907Ginsenoside Rg6 -
Similarity Score 0.85
HY-N0905Ginsenoside Rh4 -
Similarity Score 0.85
HY-N1802820(22Z)-Ginsenoside Rh4 -
Similarity Score 0.85
HY-N0602Ginsenoside Rg2 -
Similarity Score 0.85
HY-N2039R20(R)-Ginsenoside Rg2 (Standard) -
Similarity Score 0.84
HY-16941Damulin A -
Similarity Score 0.84
HY-N0908RGinsenoside Rg5 (Standard) -
Similarity Score 0.80
HY-N0601Ginsenoside Rf -
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References
- [1]. Chen B, et al. The apoptosis-inducing effect of ginsenoside F4 from steamed notoginseng on human lymphocytoma JK cells. Nat Prod Res. 2013;27(24):2351-4. [Content Brief]
- [2]. Lee JH, et al. Ginsenosides from Korean red ginseng inhibit matrix metalloproteinase-13 expression in articular chondrocytes and prevent cartilage degradation. Eur J Pharmacol. 2014 Feb 5;724:145-51. [Content Brief]
