74285-86-2
74285-86-2
Chemical Structure
Triptophenolide
Synonym(s): Hypolide; (+)-Triptophenolide
- CAS No.: 74285-86-2
- Formula:C20H24O3
- Molecular Weight:312.40
IUPAC Name: (3bR,9bS)-6-hydroxy-7-isopropyl-9b-methyl-3b,4,5,9b,10,11-hexahydrophenanthro[1,2-c]furan-1(3H)-one
InChIKey: KPXIBWGPZSPABK-FXAWDEMLSA-N
SMILES: O=C1C(CC[C@]2(C)C3=C(CC[C@]24[H])C(O)=C(C(C)C)C=C3)=C4CO1
Biological Activity: Triptophenolide (Hypolide) is a colorless crystal isolated from the ethyl acetate extract of Tripterygium wilfordii. Triptophenolide is an orally active pan‑antagonist of the androgen receptor (AR) with an IC50 of 467 nM against human wild‑type AR. Triptophenolide reduces AR expression, inhibits AR nuclear translocation, downregulates prostate‑specific antigen mRNA levels, and suppresses the growth of AR‑positive prostate cancer cells. Triptophenolide shows anti-tumor effects against breast cancer by inhibiting cell proliferation and migration, inducing G1-phase arrest and apoptosis, repressing xenograft tumor growth. Triptophenolide inhibits pyroptosis, alleviates tissue inflammation, and ameliorates synovial injury. Triptophenolide can be used for the study of prostate cancer, rheumatoid arthritis and breast cancer[1][2][3].
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Triptophenolide | 99.98% | Triptophenolide (Hypolide) is a colorless crystal isolated from the ethyl acetate extract of Tripterygium wilfordii. Triptophenolide is an orally active pan‑antagonist of the androgen receptor (AR) with an IC50 of 467 nM against human wild‑type AR. Triptophenolide reduces AR expression, inhibits AR nuclear translocation, downregulates prostate‑specific antigen mRNA levels, and suppresses the growth of AR‑positive prostate cancer cells. Triptophenolide shows anti-tumor effects against breast cancer by inhibiting cell proliferation and migration, inducing G1-phase arrest and apoptosis, repressing xenograft tumor growth. Triptophenolide inhibits pyroptosis, alleviates tissue inflammation, and ameliorates synovial injury. Triptophenolide can be used for the study of prostate cancer, rheumatoid arthritis and breast cancer. | ||||||||||||||||||||
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Triptophenolide (Standard) | ≥98% | Triptophenolide (Standard) (Hypolide) is the analytical standard of Triptophenolide (HY-N0475). This product is intended for research and analytical applications. Triptophenolide is a colorless crystal isolated from the ethyl acetate extract of Tripterygium wilfordii. Triptophenolide is an orally active pan‑antagonist of the androgen receptor (AR) with an IC50 of 467 nM against human wild‑type AR. Triptophenolide reduces AR expression, inhibits AR nuclear translocation, downregulates prostate‑specific antigen mRNA levels, and suppresses the growth of AR‑positive prostate cancer cells. Triptophenolide shows anti-tumor effects against breast cancer by inhibiting cell proliferation and migration, inducing G1-phase arrest and apoptosis, repressing xenograft tumor growth. Triptophenolide inhibits pyroptosis, alleviates tissue inflammation, and ameliorates synovial injury. Triptophenolide can be used for the study of prostate cancer, rheumatoid arthritis and breast cancer. | ||||||||||||||||||||
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14-Hydroxydehydroabietane | 14-Hydroxydehydroabietane is a ribosomal enzyme inhibitor. 14-Hydroxydehydroabietane exhibits in vitro antileishmanial activity against promastigotes, amastigotes and intracellular amastigotes of Leishmania infantum and Leishmania braziliensis. 14-Hydroxydehydroabietane induces ultrastructural changes in Leishmania braziliensis promastigotes. 14-Hydroxydehydroabietane reduces the infection rate of macrophages by Leishmania infantum and Leishmania braziliensis. 14-Hydroxydehydroabietane can be used for the research of leishmaniasis. | |||||||||||||||||||||
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Triptonoterpene | 99.12% | Triptonoterpene is a natural product that can be isolated from the roots of Tripterygium wilfordii Hook. f.. | ||||||||||||||||||||
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Triptoditerpenic acid B | Triptoditerpenic acid B is a chemical component that can be extracted from Tripterygium Hypoglaucium (Lévi.) Hutch. Triptoditerpenic acid B is a diterpenoid compound. | |||||||||||||||||||||
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Neotriptonoterpene | Neotriptonoterpene, a compound isolated from T. regelii, shows weak cytotoxic activity against A2780, HepG2 and MCF-7 cells with IC50 values of 65.80, 35.45 and 64.80 µM respectively. | |||||||||||||||||||||
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Triptoquinonide | Triptoquinonide is a Diterpenoids product that can be isolated from the vines of Tripterygium wilfordii. | |||||||||||||||||||||
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Triptobenzene H | Triptobenzene H (Hypoglic acid) significantly increases TNF-α and IL-1β mRNA levels in macrophages, causing indirect liver damage. | |||||||||||||||||||||
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Triptonoterpene Me ether | Triptonoterpene Me ether (compound 5) is a rosinane-type diterpenoid compound, which can be isolated from the traditional Chinese medicine Tripterygium wilfordii Hook. f. | |||||||||||||||||||||
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Rospiglioside aglycon | Rospiglioside aglycon (4beta-Carboxynortotarol) is a Miscellaneous product that can be isolated from the herbs of Conyza stricta. | |||||||||||||||||||||
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Neotriptophenolide | 99.77% | Neotriptophenolide is a sesquiterpene pyridine alkaloid isolated from the root barks of Tripterygium hypoglaucum. | ||||||||||||||||||||
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Triptinin B | Triptinin B (compound 2) is a LTD4 antagonist that can be isolated from Tripterygium wilfordii. | |||||||||||||||||||||
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References
- [1]. He Y, et al. Identification of Triptophenolide from Tripterygium wilfordii as a Pan-antagonist of Androgen Receptor. ACS Med Chem Lett. 2016 Sep 28;7(12):1024-1027. [Content Brief]
- [2]. Pu X, et al. Triptophenolide Improves Rheumatoid Arthritis and Progression by Inducing Macrophage Toxicity. J Biochem Mol Toxicol. 2025;39(1):e70096. [Content Brief]
- [3]. Gao J, et al. Triptolide: pharmacological spectrum, biosynthesis, chemical synthesis and derivatives. Theranostics. 2021;11(15):7199-7221. Published 2021 May 24. [Content Brief]
