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metabolite of Acetaminophen

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Metabolite (10) Endogenous Metabolite (9) Drug Intermediate (1) Isotope-Labeled Compounds (1) Reference Standards (4)
By Research Areas:	Inflammation/Immunology (5) Metabolic Disease (7)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Drug Metabolite Endogenous Metabolite

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113381

2-Hydroxybutyric acid 1 Publications Verification α-Hydroxybutyric acid	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
2-Hydroxybutyric acid (α-Hydroxybutyric acid ) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . 2-Hydroxybutyric acid is a potential biomarker for type 2 diabetes and preeclampsia . 2-Hydroxybutyric acid prevents the acetaminophen (AP)-induced liver injury .

HY-W017464

NAPQI N-Acetyl-4-benzoquinone Imine	Drug Metabolite Endogenous Metabolite	Metabolic Disease
NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver .

HY-113083

Acetaminophen glucuronide APAP-glu	Drug Metabolite Endogenous Metabolite	Others
Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-G0004

**Acetaminophen metabolite 3-hydroxy-acetaminophen** 3-HydroxyAcetaminophen	Drug Metabolite	Inflammation/Immunology
Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen) is a non-toxic metabolite and antioxidant of acetaminophen (HY-66005) with free radical scavenging activity. Acetaminophen metabolite 3-hydroxy-acetaminophen can reduce oxidative damage by exerting electron donation ability and antioxidant activity through phenolic hydroxyl groups. 3-hydroxy-acetaminophen can be used to study the toxicity mechanism and drug metabolism of acetaminophen .

HY-W012790

Sodium 2-hydroxybutanoate 1 Publications Verification 2-Hydroxybutyric acid sodium	Endogenous Metabolite	Metabolic Disease
Sodium 2-hydroxybutanoate (2-Hydroxybutyric acid sodium) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . Sodium 2-hydroxybutanoate is a potential biomarker for type 2 diabetes and preeclampsia . Sodium 2-hydroxybutanoate prevents the acetaminophen (AP)-induced liver injury .

HY-138128

Acetaminophen mercapturate	Drug Metabolite	Inflammation/Immunology
Acetaminophen mercapturate is a metabolite of Acetaminophen. Acetaminophen is a selective COX-2 inhibitor .

HY-W012790S

Sodium 2-hydroxybutanoate-d3	Endogenous Metabolite	Metabolic Disease
Sodium 2-hydroxybutanoate-d₃ is the deuterium labeled Sodium 2-hydroxybutanoate . Sodium 2-hydroxybutanoate (2-Hydroxybutyric acid sodium) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . Sodium 2-hydroxybutanoate is a potential biomarker for type 2 diabetes and preeclampsia . Sodium 2-hydroxybutanoate prevents the acetaminophen (AP)-induced liver injury .

HY-G0004R

Acetaminophen metabolite 3-hydroxy-acetaminophen (Standard) 3-HydroxyAcetaminophen (Standard)	Reference Standards Drug Metabolite	Inflammation/Immunology
Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen) (Standard) is the analytical standard of Acetaminophen metabolite 3-hydroxy-acetaminophen (HY-G0004). This product is intended for research and analytical applications. Acetaminophen metabolite 3-hydroxy-acetaminophen is a non-toxic metabolite and antioxidant of acetaminophen (HY-66005) with free radical scavenging activity. Acetaminophen metabolite 3-hydroxy-acetaminophen can reduce oxidative damage by exerting electron donation ability and antioxidant activity through phenolic hydroxyl groups. 3-hydroxy-acetaminophen can be used to study the toxicity mechanism and drug metabolism of acetaminophen .

HY-113083R

Acetaminophen glucuronide (Standard) APAP-glu (Standard)	Reference Standards Drug Metabolite Endogenous Metabolite	Others
Acetaminophen glucuronide (Standard) is the analytical standard of Acetaminophen glucuronide. This product is intended for research and analytical applications. Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-W012790R

Sodium 2-hydroxybutanoate (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Sodium 2-hydroxybutanoate is an endogenous metabolite. Sodium 2-hydroxybutanoate (2-Hydroxybutyric acid sodium) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . Sodium 2-hydroxybutanoate is a potential biomarker for type 2 diabetes and preeclampsia . Sodium 2-hydroxybutanoate prevents the acetaminophen (AP)-induced liver injury .

HY-W744265

NAPQI-d3 N-Acetyl-4-benzoquinone Imine-d₃	Isotope-Labeled Compounds Drug Metabolite Endogenous Metabolite	Metabolic Disease
NAPQI-d₃ (N-Acetyl-4-benzoquinone Imine-d₃) is the deuterium labeled NAPQI (HY-W017464). NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver .

HY-113083A

Acetaminophen glucuronide potassium APAP-glu potassium	Drug Metabolite	Others
Acetaminophen glucuronide potassium (APAP-glu potassium) is the inactive glucuronide metabolite of Acetaminophen (HY-66005). Acetaminophen glucuronide potassium can be used as a biomarker to measure glucuronidation activity or hepatic drug metabolism capacity .

HY-W725454

Acetaminosalol	Drug Metabolite Drug Intermediate	Inflammation/Immunology
Acetaminosalol, a merged ester NSAID–APAP hybrid, is a metabolite of Benorylate (HY-107795) and a prodrug of Acetaminophen (HY-66005) and Aalicylic acid (HY-B0167). Acetaminosalol can be used for the research of acute rheumatism .

HY-W017464R

NAPQI (Standard) N-Acetyl-4-benzoquinone Imine (Standard)	Drug Metabolite Reference Standards Endogenous Metabolite	Metabolic Disease
NAPQI (Standard) is the analytical standard of NAPQI (HY-W017464). This product is intended for research and analytical applications. NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113381

2-Hydroxybutyric acid 1 Publications Verification α-Hydroxybutyric acid	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Endocrine diseases Metabolic Disease Endogenous metabolite Disease Research Fields Cardiovascular System Disorder Source Classification	Endogenous Metabolite
2-Hydroxybutyric acid (α-Hydroxybutyric acid ) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . 2-Hydroxybutyric acid is a potential biomarker for type 2 diabetes and preeclampsia . 2-Hydroxybutyric acid prevents the acetaminophen (AP)-induced liver injury .

HY-W017464

NAPQI N-Acetyl-4-benzoquinone Imine	Alkaloids Classification of Application Fields Other Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Drug Metabolite Endogenous Metabolite
NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver .

HY-113083

Acetaminophen glucuronide APAP-glu	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Drug Metabolite Endogenous Metabolite
Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-W012790

Sodium 2-hydroxybutanoate 1 Publications Verification 2-Hydroxybutyric acid sodium	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Sodium 2-hydroxybutanoate (2-Hydroxybutyric acid sodium) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . Sodium 2-hydroxybutanoate is a potential biomarker for type 2 diabetes and preeclampsia . Sodium 2-hydroxybutanoate prevents the acetaminophen (AP)-induced liver injury .

HY-113083R

Acetaminophen glucuronide (Standard) APAP-glu (Standard)	Structural Classification Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Reference Standards Drug Metabolite Endogenous Metabolite
Acetaminophen glucuronide (Standard) is the analytical standard of Acetaminophen glucuronide. This product is intended for research and analytical applications. Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005) . Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-W012790R

Sodium 2-hydroxybutanoate (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Sodium 2-hydroxybutanoate is an endogenous metabolite. Sodium 2-hydroxybutanoate (2-Hydroxybutyric acid sodium) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . Sodium 2-hydroxybutanoate is a potential biomarker for type 2 diabetes and preeclampsia . Sodium 2-hydroxybutanoate prevents the acetaminophen (AP)-induced liver injury .

HY-W017464R

NAPQI (Standard) N-Acetyl-4-benzoquinone Imine (Standard)	Structural Classification Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Drug Metabolite Reference Standards Endogenous Metabolite
NAPQI (Standard) is the analytical standard of NAPQI (HY-W017464). This product is intended for research and analytical applications. NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver .

Cat. No.	Product Name	Chemical Structure

HY-W012790S

Sodium 2-hydroxybutanoate-d3
Sodium 2-hydroxybutanoate-d₃ is the deuterium labeled Sodium 2-hydroxybutanoate . Sodium 2-hydroxybutanoate (2-Hydroxybutyric acid sodium) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . Sodium 2-hydroxybutanoate is a potential biomarker for type 2 diabetes and preeclampsia . Sodium 2-hydroxybutanoate prevents the acetaminophen (AP)-induced liver injury .

Sodium 2-hydroxybutanoate-d3

Sodium 2-hydroxybutanoate-d₃ is the deuterium labeled Sodium 2-hydroxybutanoate . Sodium 2-hydroxybutanoate (2-Hydroxybutyric acid sodium) is converted from 2-Aminobutyric acid, with 2-oxobutyric acid as an intermediate metabolite . Sodium 2-hydroxybutanoate is a potential biomarker for type 2 diabetes and preeclampsia . Sodium 2-hydroxybutanoate prevents the acetaminophen (AP)-induced liver injury .

HY-W744265

NAPQI-d3
NAPQI-d₃ (N-Acetyl-4-benzoquinone Imine-d₃) is the deuterium labeled NAPQI (HY-W017464). NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver .

NAPQI-d3

NAPQI-d₃ (N-Acetyl-4-benzoquinone Imine-d₃) is the deuterium labeled NAPQI (HY-W017464). NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver .

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