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microtubule-targeting agent

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By Targets:	ADC Payload (2) Apoptosis (6) Checkpoint Kinase (Chk) (2) Drug Derivative (1) HDAC (1) Kinesin (1) Microtubule/Tubulin (14) Reference Standards (1)
By Research Areas:	Cancer (14)

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13442

Eribulin 5+ Cited Publications B1939; E7389; ER-086526	Microtubule/Tubulin Apoptosis ADC Payload	Cancer
Eribulin (E7389) is a *microtubule* targeting agent that is used for the research of metastatic breast cancer. Eribulin inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules.

HY-N2146

Combretastatin A4 4 Publications Verification CRC 87-09	Microtubule/Tubulin	Cancer
Combretastatin A4 is a *microtubule*-targeting agent that binds β-tubulin with K_d of 0.4 μM.

HY-173522

KIF2C-IN-1	Kinesin Microtubule/Tubulin	Cancer
KIF2C-IN-1 is a cell-penetrating, selective KIF2C inhibitor with fluorescent properties (E_x/E_m = 410/510 nm). KIF2C-IN-1 exhibits notable cytotoxicity and weak inhibitory effects on KIF2A/B. KIF2C-IN-1 prohibits the dissociation of KIF2C from microtubules. KIF2C-IN-1 inhibiting KIF2C reverses cross-resistance to microtubule-targeting agents. KIF2C-IN-1 reduces tumorigenesis in chemoresistant triple-negative breast cancer (TNBC) model in mice with the combination of Paclitaxel (HY-B0015) .

HY-127079

Epothilone F	Microtubule/Tubulin	Cancer
Epothilone F is a 16-membered macrolide microtubule-targeting agent. Epothilone F exhibits significant anticancer activity, and it particularly exerts effective inhibitory effects on paclitaxel-resistant cancer cells. Epothilone F inhibits the proliferation of breast cancer cells, non-small cell lung cancer cells and drug-resistant ovarian cancer cells, and it has been widely used in cancer-related research .

HY-13442AS

Eribulin-d3 mesylate	Microtubule/Tubulin Apoptosis	Cancer
Eribulin-d₃ (mesylate) is a deuterium labeled Eribulin mesylate. Eribulin mesylate is a microtubule targeting agent that is used for the research of cancer .

HY-19916

Lisavanbulin BAL-101553	Microtubule/Tubulin Checkpoint Kinase (Chk)	Cancer
Lisavanbulin (BAL-101553) is the prodrug of the microtubule targeting agent Avanbulin (BAL 27862) (HY-106008). Lisavanbulin is a BBB-penetrant and orally active antitumor agent, especially in tumors that express high levels of end-binding protein 1. Lisavanbulin has ability to target tumor cell proliferation and affects the tumor microenvironment by reducing tumor microvasculature. Lisavanbulin is also a spindle assembly checkpoint activator. Lisavanbulin induces cell cycle arrest and subsequent death or aberrant chromosome segregation. Lisavanbulin can be studied in research for diffuse large B cell lymphoma (DLBCL) and glioblastoma .

HY-19916A

Lisavanbulin dihydrochloride BAL-101553 dihydrochloride	Microtubule/Tubulin Checkpoint Kinase (Chk)	Cancer
Lisavanbulin (BAL-101553) dihydrochloride is the prodrug of the microtubule targeting agent Avanbulin (BAL 27862) (HY-106008). Lisavanbulin dihydrochloride exhibits antitumor activity, especially in tumors that express high levels of end-binding protein 1. Lisavanbulin dihydrochloride has ability to target tumor cell proliferation and affects the tumor microenvironment by reducing tumor microvasculature. Lisavanbulin dihydrochloride is also a spindle assembly checkpoint activator. Lisavanbulin dihydrochloride induces cell cycle arrest and subsequent death or aberrant chromosome segregation. Lisavanbulin dihydrochloride can be studied in research for diffuse large B cell lymphoma (DLBCL) and glioblastoma .

HY-N2146R

Combretastatin A4 (Standard) CRC 87-09 (Standard)	Reference Standards Microtubule/Tubulin	Cancer
Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.

HY-163737

ST-401	Microtubule/Tubulin	Cancer
ST-401, a microtubule-targeting agent (MTA), is a brain-penetrant microtubule (MT) assembly inhibitor. ST-401 disrupts microtubule (MT) function through gentle and reverisible reduction in MT assembly that triggers mitotic delay and cell death in interphase. ST-401 shows a potent antitumor activity .

HY-177549

Fmoc-PEG6-VCP-Eribulin	Drug Derivative ADC Payload Microtubule/Tubulin Apoptosis	Cancer
Fmoc-PEG6-VCP-Eribulin is the derivative of Eribulin (HY-13442). Eribulin (E7389) is a *microtubule* targeting agent that is used for the research of metastatic breast cancer. Eribulin inhibits the proliferation of cancer cells by binding microtubule proteins and microtubules .

HY-124624

PBOX-15	Microtubule/Tubulin Apoptosis	Cancer
PBOX-15 is a microtubule targeting agent. PBOX-15 induces apoptosis by promoting tubulin depolymerization in tumor cells .

HY-178325

Tubulin-IN-57	Microtubule/Tubulin Apoptosis	Cancer
Tubulin-IN-57 is a Tubulin inhibitor. Tubulin-IN-57 is a potent antiproliferative agent that inhibits clonogenic formation, migration, and invasion of ovarian cancer cells. Tubulin-IN-57 inhibits tubulin polymerization, which in turn induces G2/M arrest and apoptosis in SKOV3 cells. Tubulin-IN-57 demonstrates potent antitumor activity without observable toxicity in an SKOV3 xenograft model. Y60S can be used for the study of ovarian cancer .

HY-146392

HDAC-IN-39	HDAC Microtubule/Tubulin Apoptosis	Cancer
HDAC-IN-39 (compound 16c) is a potent HDAC inhibitor, with IC₅₀ values of 1.07 μM (HDAC1), 1.47 μM (HDAC2), and 2.27 μM (HDAC3), respectively. HDAC-IN-39 also significantly inhibits microtubule polymerization. HDAC-IN-39 induces cell cycle arrest at the G2/M phase. HDAC-IN-39 displays promising anticancer activity against resistant cancer cells .

HY-120120

DZ-2384	Microtubule/Tubulin	Cancer
DZ-2384 is a potent *microtubule*-targeting agent. DZ-2384 increases the rescue frequency and preserves the microtubule network in nonmitotic cells and primary neurons. DZ-2384 acts synergistically with anti-CTLA-4 immunotherapy in Taxane-sensitive and Taxane-resistant xenograft murine models of triple-negative breast cancer (TNBC). DZ-2384 exhibits potent antitumor activity in adult acute lymphocytic leukemia (ALL) models. DZ-2384 can be used for cancer research, such as TNBC and ALL ^[1][2].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2146

Combretastatin A4 4 Publications Verification CRC 87-09	Structural Classification Monophenols other families Stilbenes Classification of Application Fields Phenols Plants Disease Research Fields Source Classification Cancer	Microtubule/Tubulin
Combretastatin A4 is a *microtubule*-targeting agent that binds β-tubulin with K_d of 0.4 μM.

HY-N2146R

Combretastatin A4 (Standard) CRC 87-09 (Standard)	Structural Classification Monophenols other families Stilbenes Phenols Plants Source Classification	Reference Standards Microtubule/Tubulin
Combretastatin A4 is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM.

Cat. No.	Product Name	Chemical Structure

HY-13442AS

Eribulin-d3 mesylate
Eribulin-d₃ (mesylate) is a deuterium labeled Eribulin mesylate. Eribulin mesylate is a microtubule targeting agent that is used for the research of cancer .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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microtubule-targeting agent

Inhibitors & Agonists

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Isotope-Labeled Compounds

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