208518-52-9
Chemical Structure
Epothilone F
- CAS No.: 208518-52-9
- Formula:C27H41NO7S
- Molecular Weight:523.68
IUPAC Name: (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-3-((E)-1-(2-(hydroxymethyl)thiazol-4-yl)prop-1-en-2-yl)-8,8,10,12,16-pentamethyl-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
InChIKey: UKIMCRYGLFQEOE-RGJAOAFDSA-N
SMILES: O=C(O[C@@H](C[C@H]1[C@@](C)(CCC[C@@H]([C@@H]([C@H](C(C2(C)C)=O)C)O)C)O1)/C(C)=C/C3=CSC(CO)=N3)C[C@@H]2O
Biological Activity: Epothilone F is a 16-membered macrolide microtubule-targeting agent. Epothilone F exhibits significant anticancer activity, and it particularly exerts effective inhibitory effects on paclitaxel-resistant cancer cells. Epothilone F inhibits the proliferation of breast cancer cells, non-small cell lung cancer cells and drug-resistant ovarian cancer cells, and it has been widely used in cancer-related research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Epothilone F | 99.00% | Epothilone F is a 16-membered macrolide microtubule-targeting agent. Epothilone F exhibits significant anticancer activity, and it particularly exerts effective inhibitory effects on paclitaxel-resistant cancer cells. Epothilone F inhibits the proliferation of breast cancer cells, non-small cell lung cancer cells and drug-resistant ovarian cancer cells, and it has been widely used in cancer-related research. | ||||||||||||||||||||
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References
- [1]. Flörsheimer A, et al. Epothilones and their analogues-a new class of promising microtubule inhibitors[J]. Expert Opinion on Therapeutic Patents, 2001, 11(6): 951-968.
- [2]. Hardt IH, et al. New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies. J Nat Prod. 2001 Jul;64(7):847-56. [Content Brief]
- [3]. Cheng H, et al. Synthesis and antitumor activity of epothilone B. Eur J Med Chem. 2018;157:925-934. [Content Brief]
