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mouse hepatitis virus

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製品番号 製品名 Target 研究分野 構造式
  • HY-128067
    5-(N,N-Hexamethylene)-amiloride
    2 Publications Verification

    Hexamethylene amiloride; HMA

    		 Sodium Channel HIV Apoptosis Infection Cancer
    5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na +/H + exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively .
    5-(N,N-Hexamethylene)-amiloride
  • HY-B0338
    Rimantadine

    1-Rimantadine

    		 Influenza Virus Autophagy Infection
    Rimantadine (1-Rimantadine) is an orally active inhibitor for M2 protein, which blocks the hydrogen ion channel activity, prevents the entry and replication of the virus, and exhibits board-spectrum antiviral activity. Rimantadine significantly inhibits hepatitis A virus (HAV) replication at the post-entry stage in Huh7 cells. Rimantadine enhances autophagy. Rimantadine has a significant protective effect against H3N2 virus in mouse model .
    Rimantadine
  • HY-P990223
    Anti-Mouse IL-15 Antibody (AIO.3)

    		Interleukin Related Infection Others Inflammation/Immunology Cancer
    Anti-Mouse IL-15 Antibody (AIO.3) is a rat-derived IgG2a λ type antibody inhibitor, targeting to mouse IL-15. Anti-Mouse IL-15 Antibody (AIO.3) can neutralize IL-15. Anti-Mouse IL-15 Antibody (AIO.3) can be used for the researches of cancer, infection and inflammation, such as hepatitis virus infection and esophagitis .
    Anti-Mouse IL-15 Antibody (AIO.3)
  • HY-P991112
    Anti-Mouse CD8α Antibody (YTS169.4)

    		Transmembrane Glycoprotein Infection
    Anti-Mouse CD8α Antibody (YTS169.4) is an IgG2 monoclonal antibody targeting mouse CD8α. Anti-Mouse CD8α Antibody (YTS169.4) rapidly depletes or downregulates CD8 + T cells in the spleens of Biozzi AB/H mice. Anti-Mouse CD8α Antibody (YTS169.4) is applicable to research related to hepatitis B virus infection . Recommended isotype control: Rat IgG2b kappa, Isotype Control (HY-P990682).
    Anti-Mouse CD8α Antibody (YTS169.4)
  • HY-P990828
    Anti-PD-L1/B7-H1 Antibody (29E.2A3)

    		PD-1/PD-L1 Infection
    Anti-PD-L1/B7-H1 Antibody (29E.2A3) is a kind of mouse IgG2b κ chimeric antibody inhibitor, targeting to human PD-L1/B7-H1. Anti-PD-L1/B7-H1 Antibody (29E.2A3) can block the binding of PD-1 to PD-L1. Anti-PD-L1/B7-H1 Antibody (29E.2A3) can be used for the research of infection, such as hepatitis C virus (HCV) .
    Anti-PD-L1/B7-H1 Antibody (29E.2A3)
  • HY-N8107
    Matairesinol monoglucoside
    2 Publications Verification

    		 STING IFNAR HBV Infection
    Matairesinol monoglucoside is a STING activator. Matairesinol monoglucoside modulates the STING-TBK1-IRF3 signaling axis, promotes STING transcriptional expression, increases TBK1 and IRF3 phosphorylation. Matairesinol monoglucoside induces IFN-α and IFN-β production, reduces HBV DNA, HBsAg, and HBeAg expression. Matairesinol monoglucoside can be used for the research of hepatitis b virus (hbv) infection .
    Matairesinol monoglucoside
  • HY-163532
    FLS-359

    		Sirtuin Infection
    FLS-359 is a selective, orally active allosteric modulator for sirtuin 2, with the IC50 of 3 μM. FLS-359 exhibits antiviral activity against RNA and DNA virus, through inhibition of DNA/RNA replication .
    FLS-359
  • HY-177300
    TLR7/8 agonist 13

    		Toll-like Receptor (TLR) HBV IFNAR Interleukin Related Infection Inflammation/Immunology
    TLR7/8 agonist 13 is an orally active dual agonist of TLR7 (lowest effective concentrations (LEC) [hTLR7] = 1.6 μM) and TLR8 (LEC [hTLR8] = 1.6 μM). TLR7/8 agonist 13 exhibits agonistic activity against human peripheral blood mononuclear cells (hPBMCs) (LEC [hPBMC] = 0.5 μM). TLR7/8 agonist 13 induces endogenous IFNα, activating myeloid dendritic cells and monocytes toward a TH1 phenotype in mice and cynomolgus monkeys. TLR7/8 agonist 13 reduces viral load and HBV surface antigen expression in a mouse model of chronic AAV-HBV infection. TLR7/8 agonist 13 has the potential to indirectly induce IFNγ, which may promote HBV antigen-specific CD8 T cell-mediated responses. TLR7/8 agonist 13 can be used to study hepatitis B virus .
    TLR7/8 agonist 13
  • HY-128067R
    5-(N,N-Hexamethylene)-amiloride (Standard)

    Hexamethylene amiloride (Standard); HMA (Standard)

    		 Sodium Channel HIV Apoptosis Reference Standards Infection Cancer
    5-(N,N-Hexamethylene)-amiloride (Standard) is the analytical standard of 5-(N,N-Hexamethylene)-amiloride. This product is intended for research and analytical applications. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively .
    5-(N,N-Hexamethylene)-amiloride (Standard)
  • HY-152535
    ATV041

    		HSV Infection Inflammation/Immunology
    ATV041 is an orally active Ibuprofen (HY-78131) and nucleotide analogue. ATV041 improves oral pharmacokinetic (PK) profile and tissue distribution with anti-mouse hepatitis virus (MHV) activity. ATV041 reduces viral load, tissue damage and virus-induced inflammation in a dose-dependent manner .
    ATV041
  • HY-169410
    SARS-CoV-2 3CLpro-IN-29

    		SARS-CoV Virus Protease Infection
    3CLPro-IN-3 (Compound A36) is an inhibitor for SARS-CoV-2 3CLpro with IC50 of 51.3 nM. 3CLPro-IN-3 exhibits antiviral activity against human coronavirus 229E, OC43 and mouse hepatitis virus MHV .
    SARS-CoV-2 3CLpro-IN-29
  • HY-P10382
    M133 peptide

    		MHC Inflammation/Immunology
    M133 peptide is a coronavirus-specific CD4 T cell epitope. M133 peptide is immunodominant in mice infected with the neurotropic coronavirus (the JHM strain of mouse hepatitis virus). M133 peptide forms a complex with MHC II molecules, which is recognized by specific TCRs, thereby activating CD4 T cells .
    M133 peptide
  • HY-P990236
    Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A)

    		Transmembrane Glycoprotein Infection Inflammation/Immunology Cancer
    Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) is an anti-mouse/rat/monkey/human ICOS/CD278 IgG monoclonal antibody. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) has limited effectiveness in improving T cell function and immune activation. Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A) can be used for researches on cancer and infection conditions such as gliomas and hepatitis B virus infection .
    Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A)
  • HY-179269
    SARS-CoV-2 nsp14-IN-9

    		SARS-CoV Infection
    SARS-CoV-2 nsp14-IN-9 (Compound 4P) is a selective nsp14 inhibitor with an IC50 of 0.20 μM. SARS-CoV-2 nsp14-IN-9 inhibits both mouse hepatitis virus and SARS-CoV-2 replication .
    SARS-CoV-2 nsp14-IN-9
  • HY-183576
    HBsAg-IN-1

    		HBV Infection Neurological Disease
    HBsAg-IN-1 is an orally active, highly liver-selective inhibitor of HBsAg production, with an EC50 of 0.63 nM. HBsAg-IN-1 shows no neurite growth inhibitory activity. HBsAg-IN-1 can be used in studies related to hepatitis B virus (HBV) infection .
    HBsAg-IN-1

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