5 Results for "

multidrug-resistant colon carcinoma

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "multidrug-resistant colon carcinoma" in MCE Product Catalog:

23-Hydroxybetulinic acid
23-Hydroxybetulinic acid
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Cat. No.: HY-N0566
CAS No.: 85999-40-2
Synonyms: Anemosapogenin
Category:  

Triterpenes other families Terpenoids Plants Disease Research Fields Cancer

Target:  

Apoptosis Autophagy Bcl-2 Family Caspase Survivin p38 MAPK MMP

23-Hydroxybetulinic acid (Anemosapogenin) is an orally active triterpenoid with broad-spectrum anticancer activity. 23-Hydroxybetulinic acid reduces the levels of Bcl-2 and survivin, elevates the level of Bax, promotes the cleavage/activation of caspase-3 and caspase-9, and induces apoptosis via the endogenous mitochondrial pathway involving cytochrome C release and mitochondrial membrane potential disruption. 23-Hydroxybetulinic acid arrests the cell cycle at S and G1 phases, inhibits cancer cell proliferation, blocks the MAPK signaling pathway, regulates MMP2, and induces autophagic apoptosis by upregulating beclin-1. 23-Hydroxybetulinic acid inhibits the activity and efflux function of P-gp, increases the intracellular accumulation of chemotherapeutic drugs, and synergistically enhances cytotoxicity with Doxorubicin (HY-15142). 23-Hydroxybetulinic acid inhibits the phosphorylation and nuclear translocation of STAT6, blocks M2 macrophage polarization, and reduces M2 macrophage-mediated apoptosis resistance of colon cancer cells. 23-Hydroxybetulinic acid can be used in related studies on chronic myeloid leukemia, hepatocellular carcinoma, sarcoma 180, multidrug-resistant breast cancer, leukemia, Doxorubicin-induced cardiotoxicity, and colorectal cancer .
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MX106
MX106
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Cat. No.: HY-124130
CAS No.: 2170836-81-2
Target:  

Survivin

Research Areas:  

Cancer

MX106 is a survivin inhibitor and an analog of UC-112 (HY-12842). MX106 inhibits the expression of survivin both in vitro and in vivo. MX106 suppresses the proliferation of human melanoma cells, epidermoid carcinoma cells and colon cancer cells, and also exerts inhibitory effects on multidrug-resistant cell lines overexpressing P-glycoprotein .
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23-Hydroxybetulinic acid (Standard)
23-Hydroxybetulinic acid (Standard)
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Cat. No.: HY-N0566R
CAS No.: 85999-40-2
Synonyms: Anemosapogenin (Standard)
Category:  

Triterpenes other families Terpenoids Plants

Target:  

Reference Standards Apoptosis Autophagy Bcl-2 Family Caspase Survivin p38 MAPK MMP

23-Hydroxybetulinic acid (Standard) is the analytical standard of 23-Hydroxybetulinic acid (HY-N0566). This product is intended for research and analytical applications. 23-Hydroxybetulinic acid (Anemosapogenin) is an orally active triterpenoid with broad-spectrum anticancer activity. 23-Hydroxybetulinic acid reduces the levels of Bcl-2 and survivin, elevates the level of Bax, promotes the cleavage/activation of caspase-3 and caspase-9, and induces apoptosis via the endogenous mitochondrial pathway involving cytochrome C release and mitochondrial membrane potential disruption. 23-Hydroxybetulinic acid arrests the cell cycle at S and G1 phases, inhibits cancer cell proliferation, blocks the MAPK signaling pathway, regulates MMP2, and induces autophagic apoptosis by upregulating beclin-1. 23-Hydroxybetulinic acid inhibits the activity and efflux function of P-gp, increases the intracellular accumulation of chemotherapeutic drugs, and synergistically enhances cytotoxicity with Doxorubicin (HY-15142). 23-Hydroxybetulinic acid inhibits the phosphorylation and nuclear translocation of STAT6, blocks M2 macrophage polarization, and reduces M2 macrophage-mediated apoptosis resistance of colon cancer cells. 23-Hydroxybetulinic acid can be used in related studies on chronic myeloid leukemia, hepatocellular carcinoma, sarcoma 180, multidrug-resistant breast cancer, leukemia, Doxorubicin-induced cardiotoxicity, and colorectal cancer.
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P-gp modulator-6
P-gp modulator-6
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Cat. No.: HY-164585
CAS No.: 352652-36-9
Target:  

P-glycoprotein

Research Areas:  

Cancer

P-gp modulator-6 is a P-glycoprotein (P-gp) modulator. P-gp modulator-6 regulates the substrate specificity of P-gp and enhances the efflux activity of Daunorubicin (HY-13062A) and Rhodamine 123 (HY-D0816). P-gp modulator-6 can be used in the research of multidrug-resistant cancers. P-gp modulator-6 can be used in the research of multidrug-resistant pancreatic cancer and multidrug-resistant colon cancer .
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BPR1K653 hydrochloride
BPR1K653 hydrochloride
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Cat. No.: HY-120534
CAS No.: 1192754-07-6
Target:  

Aurora Kinase Apoptosis

Research Areas:  

Cancer

BPR1K653 hydrochloride is a pan-Aurora kinase inhibitor, with an IC50 of 124.0 nM against Aurora-A and an IC50 of 45.0 nM against Aurora-B. BPR1K653 hydrochloride induces endoreduplication, apoptosis and antiproliferative activity in cancer cells. BPR1K653 hydrochloride can be used in research related to colon cancer and multidrug-resistant cancers .
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