352652-36-9
Chemical Structure
P-gp modulator-6
- CAS No.: 352652-36-9
- Formula:C16H13ClN2O2
- Molecular Weight:300.74
InChIKey: XARXXOJWHQUSIS-UHFFFAOYSA-N
SMILES: ClC1=CC=C(CC2=NOC(C3=C(OC)C=CC=C3)=N2)C=C1
Biological Activity: P-gp modulator-6 is a P-glycoprotein (P-gp) modulator. P-gp modulator-6 regulates the substrate specificity of P-gp and enhances the efflux activity of Daunorubicin (HY-13062A) and Rhodamine 123 (HY-D0816). P-gp modulator-6 can be used in the research of multidrug-resistant cancers. P-gp modulator-6 can be used in the research of multidrug-resistant pancreatic cancer and multidrug-resistant colon cancer[1][2].
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P-gp modulator-6 | P-gp modulator-6 is a P-glycoprotein (P-gp) modulator. P-gp modulator-6 regulates the substrate specificity of P-gp and enhances the efflux activity of Daunorubicin (HY-13062A) and Rhodamine 123 (HY-D0816). P-gp modulator-6 can be used in the research of multidrug-resistant cancers. P-gp modulator-6 can be used in the research of multidrug-resistant pancreatic cancer and multidrug-resistant colon cancer. | |||||||||||||||||||||
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- [1]. Kondratov RV, et al. Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoprotein. Proceedings of the National Academy of Sciences of the United States of America. 2001 Nov 20;98(24):14078-83. [Content Brief]
- [2]. Ramalhete C, et al. Triterpenoids from Momordica balsamina with a Collateral Sensitivity Effect for Tackling Multidrug Resistance in Cancer Cells. Planta medica. 2018 Dec;84(18):1372-1379. [Content Brief]
Keywords
