21 Results for "

natural chalcone

" in MedChemExpress (MCE) Product Catalog:
Products (21)

21 Results for "natural chalcone" in MCE Product Catalog:

4
4 Cited Publications
Cat. No.: HY-N2445
CAS No.: 37308-75-1
Flavokawain C is an orally active natural chalcone. Flavokawain C inhibits the proliferation of various cancer cells. Flavokawain C upregulates GADD153 in cancer cells, inhibits the phosphorylation of Akt and JNK, suppresses early ERK phosphorylation, activates late ERK phosphorylation, activates caspase related subtypes, induces PARP-1 cleavage, causes upregulation of p21 and p27, downregulation of mutant p53 and anti-apoptotic IAP proteins, elevates intracellular ROS levels, reduces SOD activity, and induces apoptosis. Flavokawain C downregulates FABP4, induces autophagy in cancer cells, and activates the AMPK/mTOR pathway . Flavokawain C decreases the expression of glycolysis-related proteins GLUT1 and HK2, and inhibits glycolysis in nasopharyngeal carcinoma cells. Flavokawain C inhibits the activation of the EGFR/PI3K/Akt/mTOR signaling pathway and reduces the expression of HSP90B1. Flavokawain C inhibits angiogenesis by decreasing the expression of angiogenic proteins Ang-1 and VEGF in human umbilical vein endothelial cells. Flavokawain C increases γ-H2AX levels in cells, inhibits the phosphorylation of FAK, PI3K and AKT in cells, and induces DNA damage in cells. Flavokawain C exerts anti-tumor activity in multiple tumor xenograft mouse models. Flavokawain C is applicable to research related to colorectal cancer, colon adenocarcinoma, nephroblastoma, nasopharyngeal carcinoma and liver cancer .
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2
2 Cited Publications
Cat. No.: HY-N1745A
CAS No.: 112408-67-0
3-Deoxysappanchalcone is a natural chalcone compound isolated from the heartwood of Caesalpinia sappan L. 3-Deoxysappanchalcone induces cell cycle arrest, ROS production, and apoptosis. 3-Deoxysappanchalcone exhibits anti-inflammatory, anti-allergic, anticoagulant, and antithrombotic activities. 3-Deoxysappanchalcone is applicable to research related to lung cancer, esophageal squamous cell carcinoma, thrombosis, and influenza virus infection .
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1
1 Cited Publications
Cat. No.: HY-N12422
3′-Methoxyfurano[4″,5″:3,4]chalcone (compound 2) is a selective A2AAR antagonist (IC50=33.5 nM) with high affinity. 3′-Methoxyfurano[4″,5″:3,4]chalcone is also a natural product obtained from the bark of Allium cepa L. 3′-Methoxyfurano[4″,5″:3,4]chalcone can promote T cell activation and can be used in cancer immunity research .
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Cat. No.: HY-N7516
CAS No.: 151135-64-7
4'-Hydroxy-2,4-dimethoxychalcone is a natural chalcone derivatives in the red herbal resin of Dracaena cochinchinensis. 4'-Hydroxy-2,4-dimethoxychalcone displays a wide range of biological activities including antimalarial, antiprotozoal, antibacterial, antifungal activity .
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Cat. No.: HY-N3057
CAS No.: 18956-15-5
Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC50 = 20.42±2.23 and 22.51±0.42 μg/mL) .
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Cat. No.: HY-N7591
CAS No.: 1393922-01-4
Millepachine is a bioactive natural chalcone from Chinese herbal medicine Millettia pachycarpa Benth, exhibits strong antitumor effects against numerous human cancer cells both in vitro and in vivo .
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Cat. No.: HY-N8707
CAS No.: 34000-39-0
Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation .
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Cat. No.: HY-N3057R
CAS No.: 18956-15-5
Pinostrobin chalcone (Standard) is the analytical standard of Pinostrobin chalcone. This product is intended for research and analytical applications. Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC50 = 20.42±2.23 and 22.51±0.42 μg/mL) .
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Cat. No.: HY-N2445R
CAS No.: 37308-75-1
Flavokawain C (Standard) is the analytical standard of Flavokawain C. This product is intended for research and analytical applications. Flavokawain C is a natural chalcone found in Kava root. Flavokawain C exerts cytotoxicity against human cancer cell lines, with an IC50 of 12.75 μM for HCT 116 cells .
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Cat. No.: HY-N7591R
CAS No.: 1393922-01-4
Millepachine (Standard) is the analytical standard of Millepachine (HY-N7591). This product is intended for research and analytical applications. Millepachine is a bioactive natural chalcone from Chinese herbal medicine Millettia pachycarpa Benth, exhibits strong antitumor effects against numerous human cancer cells both in vitro and in vivo .
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Cat. No.: HY-N16909
CAS No.: 2716080-96-3
Velutone A is a natural chalcone.
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Cat. No.: HY-N17203
CAS No.: 1464719-37-6
Taccabulin A is a natural chalcone.
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Cat. No.: HY-N15553
CAS No.: 81943-62-6
Boesenbergin A is a natural chalcone compound found in Boesenbergia pandurata Schl .
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Cat. No.: HY-N16912
CAS No.: 861074-67-1
β-Hydroxy-2',4',5'-trimethoxychalcone is a natural chalcone.
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Cat. No.: HY-N16983
CAS No.: 1885097-49-3
2',4',6'-Trihydroxydihydrochalcone-4'-O-(3''-O-galloyl)glucoside is a natural chalcone.
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Cat. No.: HY-N17162
CAS No.: 2329726-95-4
Synonyms: 4'-O-(4,6-O-Hexahydroxydiphenoyl-β-D-glucopyranosyl)phloretin
4-Hydroxythonningianin B (4'-O-(4,6-O-Hexahydroxydiphenoyl-β-D-glucopyranosyl)phloretin) is a natural chalcone.
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Cat. No.: HY-N18015
CAS No.: 65602-54-2
(E/Z)-6'-Hydroxy-3,4,2',3',4'-pentamethoxychalcone (Compound 5) is a chalcone found in Chromolaena odorata (L.) King & Robinson .
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Cat. No.: HY-W397545
CAS No.: 10496-67-0
2'-Hydroxy-3,4,4',6'-tetramethoxychalcone is a chalcone-type natural product that can be isolated from the fruits of Merrillia caloxylon. 2'-Hydroxy-3,4,4',6'-tetramethoxychalcone may be involved in the biosynthesis of flavonoids in plants.
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Cat. No.: HY-141462
CAS No.: 13323-66-5
2',4-Dihydroxychalcone is an orally active natural chalcone flavonoid. 2',4-Dihydroxychalcone restores intestinal barrier integrity by upregulating tight junction proteins, regulates intestinal flora balance and alleviates inflammation. 2',4-Dihydroxychalcone induces GPX4 degradation, ferroptosis and apoptosis, triggers cell cycle arrest, and exhibits broad anti-tumor activity. 2',4-Dihydroxychalcone also possesses antifungal activity, antileishmanial activity, and reduces the hemolytic effect and virulence of Vibrio vulnificus .
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