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Results for "

natural chalcone

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (1) Akt (1) AMPK (1) Apoptosis (4) Autophagy (1) Bacterial (1) Caspase (1) Drug Derivative (6) EGFR (1) FABP (1) FAK (1) Fungal (1) GLUT (1) HDAC (1) HSP (1) IAP (1) JNK (1) MDM-2/p53 (1) mTOR (1) NF-κB (1) Parasite (2) PARP (1) PERK (1) PI3K (1) Reactive Oxygen Species (ROS) (1) Reference Standards (3) SOD (1) VEGFR (1)
By Research Areas:	Cancer (8) Infection (2) Inflammation/Immunology (2)

Inhibitors & Agonists

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Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2445

Flavokawain C 4 Publications Verification	Apoptosis Akt JNK PERK Caspase PARP MDM-2/p53 IAP Reactive Oxygen Species (ROS) SOD FABP Autophagy AMPK mTOR GLUT EGFR PI3K HSP VEGFR FAK	Cancer
Flavokawain C is an orally active natural chalcone. Flavokawain C inhibits the proliferation of various cancer cells. Flavokawain C upregulates GADD153 in cancer cells, inhibits the phosphorylation of Akt and JNK, suppresses early ERK phosphorylation, activates late ERK phosphorylation, activates caspase related subtypes, induces PARP-1 cleavage, causes upregulation of p21 and p27, downregulation of mutant p53 and anti-apoptotic IAP proteins, elevates intracellular ROS levels, reduces SOD activity, and induces apoptosis. Flavokawain C downregulates FABP4, induces autophagy in cancer cells, and activates the AMPK/mTOR pathway . Flavokawain C decreases the expression of glycolysis-related proteins GLUT1 and HK2, and inhibits glycolysis in nasopharyngeal carcinoma cells. Flavokawain C inhibits the activation of the EGFR/PI3K/Akt/mTOR signaling pathway and reduces the expression of HSP90B1. Flavokawain C inhibits angiogenesis by decreasing the expression of angiogenic proteins Ang-1 and VEGF in human umbilical vein endothelial cells. Flavokawain C increases γ-H2AX levels in cells, inhibits the phosphorylation of FAK, PI3K and AKT in cells, and induces DNA damage in cells. Flavokawain C exerts anti-tumor activity in multiple tumor xenograft mouse models. Flavokawain C is applicable to research related to colorectal cancer, colon adenocarcinoma, nephroblastoma, nasopharyngeal carcinoma and liver cancer .

HY-N7516

4'-Hydroxy-2,4-dimethoxychalcone	Parasite Bacterial Fungal	Infection
4'-Hydroxy-2,4-dimethoxychalcone is a natural chalcone derivatives in the red herbal resin of Dracaena cochinchinensis. 4'-Hydroxy-2,4-dimethoxychalcone displays a wide range of biological activities including antimalarial, antiprotozoal, antibacterial, antifungal activity .

HY-N3057

Pinostrobin chalcone	Others	Cancer
Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC₅₀ = 20.42±2.23 and 22.51±0.42 μg/mL) .

HY-N7591

Millepachine	Apoptosis	Cancer
Millepachine is a bioactive natural chalcone from Chinese herbal medicine Millettia pachycarpa Benth, exhibits strong antitumor effects against numerous human cancer cells both in vitro and in vivo .

HY-N12422

A2AAR antagonist 2 1 Publications Verification	Adenosine Receptor	Inflammation/Immunology Cancer
3′-Methoxyfurano[4″,5″:3,4]chalcone (compound 2) is a selective A_2AAR antagonist (IC₅₀=33.5 nM) with high affinity. 3′-Methoxyfurano[4″,5″:3,4]chalcone is also a natural product obtained from the bark of Allium cepa L. 3′-Methoxyfurano[4″,5″:3,4]chalcone can promote T cell activation and can be used in cancer immunity research .

HY-N8707

Homobutein	Parasite HDAC NF-κB	Infection Inflammation/Immunology Cancer
Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC₅₀s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation .

HY-N3057R

Pinostrobin chalcone (Standard)	Reference Standards Others	Cancer
Pinostrobin chalcone (Standard) is the analytical standard of Pinostrobin chalcone. This product is intended for research and analytical applications. Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC₅₀ = 20.42±2.23 and 22.51±0.42 μg/mL) .

HY-N2445R

Flavokawain C (Standard)	Reference Standards Apoptosis	Cancer
Flavokawain C (Standard) is the analytical standard of Flavokawain C. This product is intended for research and analytical applications. Flavokawain C is a natural chalcone found in Kava root. Flavokawain C exerts cytotoxicity against human cancer cell lines, with an IC₅₀ of 12.75 μM for HCT 116 cells .

HY-N7591R

Millepachine (Standard)	Apoptosis Reference Standards	Cancer
Millepachine (Standard) is the analytical standard of Millepachine (HY-N7591). This product is intended for research and analytical applications. Millepachine is a bioactive natural chalcone from Chinese herbal medicine Millettia pachycarpa Benth, exhibits strong antitumor effects against numerous human cancer cells both in vitro and in vivo .

HY-N7469

Glabralide A	Drug Derivative	Others
Glabralide A is a natural chalcone.

HY-N16909

Velutone A	Drug Derivative	Others
Velutone A is a natural chalcone.

HY-N17203

Taccabulin A	Drug Derivative	Others
Taccabulin A is a natural chalcone.

HY-N15553

Boesenbergin A	Others	Others
Boesenbergin A is a natural chalcone compound found in Boesenbergia pandurata Schl .

HY-N16912

β-Hydroxy-2',4',5'-trimethoxychalcone	Drug Derivative	Others
β-Hydroxy-2',4',5'-trimethoxychalcone is a natural chalcone.

HY-N16983

2',4',6'-Trihydroxydihydrochalcone-4'-O-(3''-O-galloyl)glucoside	Drug Derivative	Others
2',4',6'-Trihydroxydihydrochalcone-4'-O-(3''-O-galloyl)glucoside is a natural chalcone.

HY-N17162

4-Hydroxythonningianin B 4'-O-(4,6-O-Hexahydroxydiphenoyl-β-D-glucopyranosyl)phloretin	Drug Derivative	Others
4-Hydroxythonningianin B (4'-O-(4,6-O-Hexahydroxydiphenoyl-β-D-glucopyranosyl)phloretin) is a natural chalcone.

HY-N18015

(E/Z)-6'-Hydroxy-3,4,2',3',4'-pentamethoxychalcone		Others
(E/Z)-6'-Hydroxy-3,4,2',3',4'-pentamethoxychalcone (Compound 5) is a chalcone found in Chromolaena odorata (L.) King & Robinson .

HY-W397545

2'-Hydroxy-3,4,4',6'-tetramethoxychalcone	Others	Others
2'-Hydroxy-3,4,4',6'-tetramethoxychalcone is a chalcone-type natural product that can be isolated from the fruits of Merrillia caloxylon. 2'-Hydroxy-3,4,4',6'-tetramethoxychalcone may be involved in the biosynthesis of flavonoids in plants.

Cat. No.	Product Name

HY-L068

Flavonoids Library	576 compounds
Flavonoids are an important class of natural products; particularly, they belong to a class of plant secondary metabolites having a polyphenolic structure, widely found in fruits, vegetables and certain beverages. Flavonoids can be subdivided into different subgroups depending on the carbon of the C ring on which the B ring is attached and the degree of unsaturation and oxidation of the C ring. These subgroups are: flavones, flavonols, flavanones, flavanonols, flavanols or catechins, anthocyanins and chalcones. Flavonoids are now considered as an indispensable component in a variety of nutraceutical, pharmaceutical, medicinal and cosmetic applications. This is attributed to their anti-oxidative, anti-inflammatory, anti-mutagenic and anti-carcinogenic properties coupled with their capacity to modulate key cellular enzyme function. Naturally occurring flavonoids are known to have biological activities for use as drugs, for example, in diseases like cancer, Alzheimer’s disease (AD), atherosclerosis, etc. MCE offers a unique collection of 576 natural flavonoid compounds which is a useful tool for drug discovery as an important source of lead compounds.

Flavonoids Library

576 compounds

Flavonoids are an important class of natural products; particularly, they belong to a class of plant secondary metabolites having a polyphenolic structure, widely found in fruits, vegetables and certain beverages. Flavonoids can be subdivided into different subgroups depending on the carbon of the C ring on which the B ring is attached and the degree of unsaturation and oxidation of the C ring. These subgroups are: flavones, flavonols, flavanones, flavanonols, flavanols or catechins, anthocyanins and chalcones. Flavonoids are now considered as an indispensable component in a variety of nutraceutical, pharmaceutical, medicinal and cosmetic applications. This is attributed to their anti-oxidative, anti-inflammatory, anti-mutagenic and anti-carcinogenic properties coupled with their capacity to modulate key cellular enzyme function. Naturally occurring flavonoids are known to have biological activities for use as drugs, for example, in diseases like cancer, Alzheimer’s disease (AD), atherosclerosis, etc.

MCE offers a unique collection of 576 natural flavonoid compounds which is a useful tool for drug discovery as an important source of lead compounds.

Flavokawain C 4 Publications Verification	Structural Classification Classification of Application Fields Piperaceae Plants Chalcones Flavonoids other families Phenols Polyphenols Piper methysticum G.Forst. Disease Research Fields Source Classification Cancer	Apoptosis Akt JNK PERK Caspase PARP MDM-2/p53 IAP Reactive Oxygen Species (ROS) SOD FABP Autophagy AMPK mTOR GLUT EGFR PI3K HSP VEGFR FAK
Flavokawain C is an orally active natural chalcone. Flavokawain C inhibits the proliferation of various cancer cells. Flavokawain C upregulates GADD153 in cancer cells, inhibits the phosphorylation of Akt and JNK, suppresses early ERK phosphorylation, activates late ERK phosphorylation, activates caspase related subtypes, induces PARP-1 cleavage, causes upregulation of p21 and p27, downregulation of mutant p53 and anti-apoptotic IAP proteins, elevates intracellular ROS levels, reduces SOD activity, and induces apoptosis. Flavokawain C downregulates FABP4, induces autophagy in cancer cells, and activates the AMPK/mTOR pathway . Flavokawain C decreases the expression of glycolysis-related proteins GLUT1 and HK2, and inhibits glycolysis in nasopharyngeal carcinoma cells. Flavokawain C inhibits the activation of the EGFR/PI3K/Akt/mTOR signaling pathway and reduces the expression of HSP90B1. Flavokawain C inhibits angiogenesis by decreasing the expression of angiogenic proteins Ang-1 and VEGF in human umbilical vein endothelial cells. Flavokawain C increases γ-H2AX levels in cells, inhibits the phosphorylation of FAK, PI3K and AKT in cells, and induces DNA damage in cells. Flavokawain C exerts anti-tumor activity in multiple tumor xenograft mouse models. Flavokawain C is applicable to research related to colorectal cancer, colon adenocarcinoma, nephroblastoma, nasopharyngeal carcinoma and liver cancer .

4'-Hydroxy-2,4-dimethoxychalcone	Infection Chalcones Monophenols Flavonoids Classification of Application Fields Phenols Umbelliferae Plants Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray Source Classification	Parasite Bacterial Fungal
4'-Hydroxy-2,4-dimethoxychalcone is a natural chalcone derivatives in the red herbal resin of Dracaena cochinchinensis. 4'-Hydroxy-2,4-dimethoxychalcone displays a wide range of biological activities including antimalarial, antiprotozoal, antibacterial, antifungal activity .

Pinostrobin chalcone	Chalcones Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Plants Disease Research Fields Cajanus cajan (L.) Millsp. Source Classification Cancer	Others
Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC₅₀ = 20.42±2.23 and 22.51±0.42 μg/mL) .

Millepachine	Flavonoids Chalcones Classification of Application Fields Leguminosae Millettia pachycarpa Benth. Plants Disease Research Fields Cancer Source Classification	Apoptosis
Millepachine is a bioactive natural chalcone from Chinese herbal medicine Millettia pachycarpa Benth, exhibits strong antitumor effects against numerous human cancer cells both in vitro and in vivo .

A2AAR antagonist 2 1 Publications Verification	Natural Products Liliaceae Allium cepa L. Plants Source Classification	Adenosine Receptor
3′-Methoxyfurano[4″,5″:3,4]chalcone (compound 2) is a selective A_2AAR antagonist (IC₅₀=33.5 nM) with high affinity. 3′-Methoxyfurano[4″,5″:3,4]chalcone is also a natural product obtained from the bark of Allium cepa L. 3′-Methoxyfurano[4″,5″:3,4]chalcone can promote T cell activation and can be used in cancer immunity research .

Homobutein	Classification of Application Fields Plants Compositae Infection Chalcones Flavonoids Millettia pachyloba Drake Phenols Polyphenols Inflammation/Immunology Disease Research Fields Source Classification Cancer	Parasite HDAC NF-κB
Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC₅₀s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation .

Pinostrobin chalcone (Standard)	Structural Classification Chalcones Flavonoids Leguminosae Phenols Polyphenols Plants Cajanus cajan (L.) Millsp. Source Classification	Reference Standards Others
Pinostrobin chalcone (Standard) is the analytical standard of Pinostrobin chalcone. This product is intended for research and analytical applications. Pinostrobin chalcone is found to be potent natural cytotoxic compounds against MDA-MB-231 and HT-29 colon cancer cell lines(IC₅₀ = 20.42±2.23 and 22.51±0.42 μg/mL) .

Flavokawain C (Standard)	Structural Classification Chalcones Flavonoids other families Phenols Polyphenols Piperaceae Piper methysticum G.Forst. Plants Source Classification	Reference Standards Apoptosis
Flavokawain C (Standard) is the analytical standard of Flavokawain C. This product is intended for research and analytical applications. Flavokawain C is a natural chalcone found in Kava root. Flavokawain C exerts cytotoxicity against human cancer cell lines, with an IC₅₀ of 12.75 μM for HCT 116 cells .

Millepachine (Standard)	Structural Classification Chalcones Flavonoids Millettia pachycarpa Benth. Leguminosae Plants Source Classification	Apoptosis Reference Standards
Millepachine (Standard) is the analytical standard of Millepachine (HY-N7591). This product is intended for research and analytical applications. Millepachine is a bioactive natural chalcone from Chinese herbal medicine Millettia pachycarpa Benth, exhibits strong antitumor effects against numerous human cancer cells both in vitro and in vivo .

Glabralide A	Structural Classification Other Monoterpenes Terpenoids Sarcandra glabra (Thunb.) Nakai Other Phenylpropanoids Chloranthaceae Phenylpropanoids Plants Source Classification	Drug Derivative
Glabralide A is a natural chalcone.

Velutone A	Structural Classification Chalcones Flavonoids Millettia velutina Dunn Leguminosae Plants Source Classification	Drug Derivative
Velutone A is a natural chalcone.

Taccabulin A	Structural Classification Chalcones Flavonoids Tacca J. R. Forst. & G. Forst. Plants Dioscoreaceae Source Classification	Drug Derivative
Taccabulin A is a natural chalcone.

Boesenbergin A	Structural Classification Natural Products Boesenbergia rotunda Plants Source Classification Zingiberaceae	Others
Boesenbergin A is a natural chalcone compound found in Boesenbergia pandurata Schl .

β-Hydroxy-2',4',5'-trimethoxychalcone	Structural Classification Millettia velutina Dunn Leguminosae Other Phenylpropanoids Phenylpropanoids Plants Source Classification	Drug Derivative
β-Hydroxy-2',4',5'-trimethoxychalcone is a natural chalcone.

2',4',6'-Trihydroxydihydrochalcone-4'-O-(3''-O-galloyl)glucoside	Structural Classification Chalcones Flavonoids Saxifragaceae Plants Penthorum chinense Pursh Source Classification	Drug Derivative
2',4',6'-Trihydroxydihydrochalcone-4'-O-(3''-O-galloyl)glucoside is a natural chalcone.

4-Hydroxythonningianin B 4'-O-(4,6-O-Hexahydroxydiphenoyl-β-D-glucopyranosyl)phloretin	Structural Classification Lignans Phenylpropanoids Thonningia sanguinea Vahl Plants Balanophoraceae Source Classification	Drug Derivative
4-Hydroxythonningianin B (4'-O-(4,6-O-Hexahydroxydiphenoyl-β-D-glucopyranosyl)phloretin) is a natural chalcone.

(E/Z)-6'-Hydroxy-3,4,2',3',4'-pentamethoxychalcone	Structural Classification Chromolaena odorata (L.) R. M. King & H. Rob. Simple Phenylpropanols Asteraceae Phenylpropanoids Plants Source Classification
(E/Z)-6'-Hydroxy-3,4,2',3',4'-pentamethoxychalcone (Compound 5) is a chalcone found in Chromolaena odorata (L.) King & Robinson .

2'-Hydroxy-3,4,4',6'-tetramethoxychalcone	Structural Classification Wyethia glabra A.Gray Phenols Polyphenols Plants Compositae Source Classification	Others
2'-Hydroxy-3,4,4',6'-tetramethoxychalcone is a chalcone-type natural product that can be isolated from the fruits of Merrillia caloxylon. 2'-Hydroxy-3,4,4',6'-tetramethoxychalcone may be involved in the biosynthesis of flavonoids in plants.

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