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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
neuropeptide Y2 receptor
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "neuropeptide Y2 receptor" in MCE Product Catalog:
1
1 Cited Publications
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JNJ-31020028 is a selective and brain penetrant antagonist of neuropeptide Y Y2 receptor with pIC50 values of 8.07 and 8.22 for human and rat Y2 receptor, respectively. JNJ-31020028 can be used for the research of nervous disease .
Synonyms: CGP71683A
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CGP71683 hydrochloride is a competitive neuropeptide Y5 receptor antagonist with a Ki of 1.3 nM, and shows no obvious activity at Y1 receptor (Ki, >4000 nM) and Y2 receptor (Ki, 200 nM) in cell membranes.
Cat. No.: HY-P10000
CAS No.: 123583-37-9
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CYM 9484 is a selective and highly potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM .
Cat. No.: HY-P1011
CAS No.: 113662-54-7
Synonyms: NPY 13-36
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Cat. No.: HY-P1480
CAS No.: 122341-40-6
Synonyms: neuropeptide Y (13-36), human
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SF 11 is a potent and brain penetrant neuropeptide Y Y2 receptor antagonist (IC50=199 nM). Antidepressant-like activity .
Cat. No.: HY-P1322
CAS No.: 153549-84-9
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Cat. No.: HY-P11043
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Cat. No.: HY-P1818
CAS No.: 119019-65-7
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Cat. No.: HY-P10148
CAS No.: 155709-24-3
Synonyms: Ac-[Leu28,31]-NPY (24-36)
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Cat. No.: HY-107479
CAS No.: 1094873-17-2
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(R)-JNJ-31020028 is a high affinity, selective brain penetrant neuropeptide Y Y2 receptor antagonist, with pIC50 values of 8.07, 8.22 and 8.21 for human, rat, and mouse Y2 receptor, respectively. (R)-JNJ-31020028 shows >100-fold selective versus human Y1, Y4, and Y5 receptors. (R)-JNJ-31020028 has antidepressant like effects .
Cat. No.: HY-P3676
CAS No.: 143863-88-1
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Cat. No.: HY-N6799
CAS No.: 36519-25-2
Cat. No.: HY-118198
CAS No.: 1185845-15-1
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NPY Y2 antagonist 1 (compound 36) is a pyridine-type, selective neuropeptide Y receptor (NPY) Y2 antagonist .
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JNJ-5207787 is a nonpeptidic, selective and penetrate the blood-brain barrier neuropeptide Y Y2 receptor (Y2) antagonist. JNJ-5207787 inhibits the binding of peptide YY (PYY) with pIC50s of 7.0 and 7.1 for human Y2 receptor and rat Y2 receptor, respectively. JNJ-5207787 is >100-fold selective versus human Y1, Y4, and Y5 receptors .
Cat. No.: HY-P3677
CAS No.: 102961-52-4
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Cat. No.: HY-101986C
CAS No.: 246146-31-6
Synonyms: AR-H 053591 dihydrochloride
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BIIE-0246 dihydrochloride (AR-H 053591 dihydrochloride) is a potent and highly selective non-peptide neuropeptide Y (NPY) Y2 receptor antagonist, with an IC50 value of 15 nM .
Cat. No.: HY-180406
CAS No.: 1262495-12-4
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NPY Y2 antagonist 2 is a modulator targeting the neuropeptide Y (NPY) receptor Y2, with pKi values of 6.8 nM and 7.2 nM in human and rat brains, respectively, and demonstrating blood-brain barrier penetration. NPY Y2 antagonist 2 shows selectivity for the Y1 and Y5 receptors. NPY Y2 antagonist 2 blocks the negative feedback regulation mediated by the NPY Y2 receptor, thereby increasing endogenous NPY release and enhancing Y1 receptor activation, resulting in the modulation of central neurotransmitter release. NPY Y2 antagonist 2 exhibits moderate in vivo clearance, high free fraction in rat brain, and a favorable brain/plasma ratio and brain exposure. NPY Y2 antagonist 2 is applicable for research in conditions such as mood disorders, anxiety induced by alcohol withdrawal, and social anxiety associated with nicotine withdrawal .
Cat. No.: HY-P1322A
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
