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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
28 Results for "
orexin 2 receptor
" in MedChemExpress (MCE) Product Catalog:
Products (28)
28 Results for "orexin 2 receptor" in MCE Product Catalog:
13
13 Publications Verification
Synonyms: Hypocretin-1 (human, rat, mouse)
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13
13 Publications Verification
Cat. No.: HY-106224B
Purity: 99.93%
Synonyms: Hypocretin-1 (human, rat, mouse) acetate
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13
13 Publications Verification
Cat. No.: HY-106224A
Purity: 97.13%
Synonyms: Hypocretin-1 (human, rat, mouse) TFA
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4
4 Cited Publications
Synonyms: JNJ-42847922
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Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective orexin-2 receptor (OX2R) antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain .
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3 Cited Publications
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TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1 .
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2 Cited Publications
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JNJ-10397049 is a potent and selective orexin 2 receptor (OX2R) antagonist, with a pKi of 8.3. JNJ-10397049 is 600-fold selective for the OX2R over the OX1R .
Cat. No.: HY-19320
CAS No.: 1796565-52-0
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Orexin 2 Receptor Agonist is a potent selective OX2R agonist with an EC50 of 23 nM .
Cat. No.: HY-P1340
CAS No.: 532932-99-3
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Orexin 2 Receptor Agonist 2 is a selective orexin 2 receptor agonist, extracted from patent WO2017135306A1, example 16 .
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ACT-462206 is an orally active and potent dual Orexin 1/Orexin 2 receptor antagonist with IC50s of 60 nM (Orexin 1) and 11 nM (Orexin 2), respectively. ACT-462206 exhibits brain penetration properties, and can be used for insomnia, stress/anxiety-related disorders and addiction research .
Cat. No.: HY-177073
CAS No.: 2980518-93-0
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Cleminorexton is an orally active orexin-2 receptor (OX2R) agonist with a pEC50 between 9 and 10.4. Cleminorexton can be used for narcolepsy and other conditions associated with orexin deficiency and/or excessive sleepiness .
Cat. No.: HY-172672
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Orexin 2 Receptor Agonist 3 (Compound 57) is an orally active and brain-penetrant orexin receptor type-2 (OX2) agonist (EC50: 2.5 nM). Orexin 2 Receptor Agonist 3 increases wakefulness in the orexin/ataxin-3 NT1 mouse model and healthy beagle dogs. Orexin 2 Receptor Agonist 3 can be used in the study of narcolepsy .
Cat. No.: HY-123737
CAS No.: 1431472-56-8
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MK-8133 is an orexin-2 receptor antagonist. MK-8133 can be used in the study of insomnia .
Cat. No.: HY-172412A
CAS No.: 2648350-16-5
Synonyms: ALKS 2680 enantiomer
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Alixorexton (ALKS 2680) enantiomer is the enantiomer of Alixorexton (HY-172412). Alixorexton is a selective, orally active and brain-penetrant agonist for orexin-2 receptor and can be used for hypersomnias research .
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MK-3697 is an orally active orexin 2 receptor (OX2R) antagonist, with an IC50 value of 16 nM and a Ki value of 1.1 nM against human OX2R. MK-3697 blocks the wake-promoting OX2R signaling pathway, reduces active wake time, and increases slow-wave sleep and rapid eye movement sleep time in mice, rats and dogs. MK-3697 can be used for research on insomnia .
Cat. No.: HY-178871
CAS No.: 1607428-33-0
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OX2-2303 is a potent, selective orexin-2 receptor (OX2R) antagonist. OX2-2303 exhibits excellent binding affinity towards OX2R (Ki = 0.1 nM), and shows >890-fold selectivity over OX1R. OX2-2303 can be used as a positron emission tomography (PET) radioligand for central nervous system (CNS) research .
Cat. No.: HY-100452A
CAS No.: 1610882-30-8
Synonyms: OX2R antagonist
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TCS-OX2-29 (hydrochloride) is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1 .
Cat. No.: HY-106224AS1
Synonyms: Hypocretin-1-13C18,15N3 (human, rat, mouse) TFA
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Cat. No.: HY-113555
CAS No.: 1030377-48-0
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DORA 42 is a dual orexin 1 and orexin 2 receptor antagonist with sleep efficacy in rats. DORA 42 is promising for research of insomnia .
Cat. No.: HY-146517
CAS No.: 2251017-69-1
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Orexin receptor antagonist 4 is potent and selective orexin 2 receptor (OX2R) antagonist with an IC50 of 4.27 nM. Orexin receptor antagonist 4 is 61-fold selective for the OX2R over the OX1R (IC50 of 295 nM) (WO2018206959A1; example 1) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
