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Cat. No.: HY-177073

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Cleminorexton

Cleminorexton is an orally active orexin-2 receptor (OX2R) agonist with a pEC₅₀ between 9 and 10.4. Cleminorexton can be used for narcolepsy and other conditions associated with orexin deficiency and/or excessive sleepiness.

For research use only. We do not sell to patients.

CAS No.: 2980518-93-0
Formula: C₂₄H₂₄F₄N₂O₄S
Molecular Weight:512.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Cleminorexton Chemical Structure

CAS No.: 2980518-93-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Orexin Receptor (OX Receptor) Isoforms :

In Vivo

Cleminorexton (Compound 67A/Example 47) (1-10 mg/kg, p.o., single dose) shows significant arousal-promoting activity in mouse models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2980518-93-0
Molecular Weight 512.52
Formula C₂₄H₂₄F₄N₂O₄S
SMILES

FC1=C(C2=C(C(F)=CC(F)=C2)OCCC3=O)C=CC=C1C[C@]4([H])N3CCC[C@@]4(NS(C5(CC5)F)(=O)=O)[H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gregory R. Ott, et al., Medium- or macro-cyclic benzyl-substituted heterocycle derivatives and related uses. WO2023167925A1.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References

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Cleminorexton

All Orexin Receptor (OX Receptor) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Cleminorexton Related Classifications

HY-177073 Related Classifications