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pH sensitive fluorescent probe

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

7

Fluorescent Dyes

Targets Recommended:
Cat. No. Nombre del producto Target Áreas de investigación Chemical Structure
  • HY-D1094
    Carboxy-SNARF 1 (5/6-mixture)
    1 Publications Verification

    SNARF 1

    		 Fluorescent Dye Others
    Carboxy-SNARF 1 (5/6-mixture) (SNARF 1) is a fluorescent probe that is sensitive to pH (Ex: 488 nm). Carboxy-SNARF 1 (5/6-mixture) can be used for measurement pH. Carboxy-SNARF 1 (5/6-mixture) exhibits a significant emission shift from yellow-orange (Em: 580 nm) to deep red fluorescence (Em: 640 nm) under acidic and basic conditions (pH=7-8), respectively .
    Carboxy-SNARF 1 (5/6-mixture)
  • HY-15940
    5(6)-Carboxyfluorescein
    5 Publications Verification

    5(6)-FAM; 5-(and-6)-Carboxyfluorescein mixed isomers

    		 Fluorescent Dye Cancer
    5(6)-Carboxyfluorescein (5(6)-FAM) is an amine-reactive pH-sensitive green fluorescent probe. 5(6)-Carboxyfluorescein (5(6)-FAM) can be used to label proteins, peptides and nucleotides. 5(6)-Carboxyfluorescein can be used for the detection of tumour areas in vivo .
    5(6)-Carboxyfluorescein
  • HY-118155
    9-Amino-6-chloro-2-methoxyacridine
    2 Publications Verification

    ACMA

    		 Fluorescent Dye Others
    9-Amino-6-chloro-2-methoxyacridine is a pH sensitive fluorescent probe. 9-Amino-6-chloro-2-methoxyacridine has been frequently used to measure changes in vacuolar pH when a specific substrate crosses the tonoplast through a putative H +/solute antiport system .
    9-Amino-6-chloro-2-methoxyacridine
  • HY-D0077
    2',7'-Difluorofluorescein

    Oregon green 488

    		 Fluorescent Dye Others
    2',7'-Difluorofluorescein (Oregon green 488) is a fluorescein derivative and a pH-sensitive fluorescent probe (pKa ~4.7). Upon excitation at 488 nm, 2',7'-Difluorofluorescein exhibits pH-sensitive fluorescence intensity through the formation of dianions, while its pH sensitivity decreases under excitation at 450 nm, allowing its use in ratiometric pH analysis. 2',7'-Difluorofluorescein can be used for the quantitative analysis of pH values in the range of 2-7 in submicron aerosol particles. 2',7'-Difluorofluorescein undergoes buffer-mediated and buffer-free excited-state proton transfer between different protonated forms, and its cationic form undergoes rapid excited-state deprotonation. 2',7'-Difluorofluorescein is resistant to photodegradation, maintains stable absorption and fluorescence properties within the physiological pH range, and serves as a fluorescent protein label, a component of Ca 2+ indicators, a fluorescent imaging agent, and an anisotropy probe .
    2',7'-Difluorofluorescein
  • HY-W110898
    Nile blue chloride

    		Fluorescent Dye Others
    Nile blue chloride is a highly fluorescent and photostable organic dye. Nile blue chloride and fluorescein isothiocyanate (FITC) can be used to construct a ratiometric pH sensitive probe for tracking the pH of the extracellular fluid between cancer cells in realtime. Nile Blue chloride has the potential for the research of nonlinear optics .
    Nile blue chloride
  • HY-124473
    Naphthofluorescein

    NapHthafluorescein

    		 HIF/HIF Prolyl-Hydroxylase Cancer
    Naphthofluorescein inhibits the interaction between HIF-1 and Mint3. Naphthofluorescein suppresses Mint3-dependent HIF-1 activity and glycolysis in cancer cells and macrophages without cytotoxicity in vitro and adverse effect in vivo . Naphthofluorescein is also a fluorescent pH-sensitive probe that can be used for functional Cerenkov imaging .
    Naphthofluorescein
  • HY-D1457
    DND-189

    		Fluorescent Dye Others
    DND-189, a low-pH fluorescent probe, is sensitive to neutral and low pH range. DND-189 can be used to measure the pH of acidic organelles .
    DND-189
  • HY-D1093
    Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture)

    		Fluorescent Dye Others
    Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture) is a fluorescent probe that is sensitive to pH. Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture) can be used for measurement of intracellular pH .
    Carboxy SNARF-1, acetoxymethyl ester (5/6-mixture)
  • HY-157036
    INSA

    		Fluorescent Dye Others
    INSA is a a pH-sensitive fluorescent probe. INSA can simultaneously light up mitochondria (red emission) and lysosomes (green emission) for their internal pH differences .
    INSA
  • HY-20794
    8-Hydroxyjulolidine

    		Fluorescent Dye Others
    8-Hydroxyjulolidine is a chromophore moiety of a fluorescent probe for the detection of weak acid ions. 8-Hydroxyjulolidine can be used to synthesize the salicylaldehyde derivative 9-formyl-8-hydroxyjulolidine, which exhibits sensitive detection ability to pH changes of hydrogen sulfide and silicate in aqueous solution .
    8-Hydroxyjulolidine
  • HY-150175
    HKSOX-1

    		Fluorescent Dye Inflammation/Immunology
    HKSOX-1 and its derivatives (HKSOX-1r and HKSOX-1m) are novel fluorescent probes designed for highly sensitive and selective detection of the superoxide anion radical (O2 •−) in cellular environments. These probes utilize an aryl trifluoromethanesulfonate group that undergoes O2 •−-mediated cleavage, releasing a free phenol and emitting fluorescence. They demonstrate excellent specificity and sensitivity across various pH ranges, withstand interference from strong oxidants and reductants typical in cellular contexts. HKSOX-1r, optimized for cellular retention, has been effectively employed in diverse assays including confocal imaging, flow cytometry, and zebrafish embryo studies, highlighting its utility in investigating O2 •− roles in inflammation, mitochondrial stress, and other physiological processes .
    HKSOX-1
  • HY-D2998
    ONOO-LysopH

    		Fluorescent Dye Others
    ONOO-LysopH is a new Rhodamine-based near-infrared fluorescent probe. ONOO-LysopH is acid-sensitive, exhibiting rapid near-infrared fluorescence enhancement around 686 nm under acidic pH conditions. ONOO-LysopH also displays a rapid NIR turn-on fluorescence around 678 nm for ONOO− at physiological pH. ONOO-LysopH can target lysosomes to track lysosomal pH changes and image endogenous/exogenous ONOO− in live cells. ONOO-LysopH is applicable for cell imaging ONOO− and tracking lysosomal pH changes .
    ONOO-LysopH

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