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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
pde11 inhibitor
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "pde11 inhibitor" in MCE Product Catalog:
2
2 Cited Publications
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BC11-38 is a potent, selective, and biologically active PDE11 inhibitor, with IC50s of 0.28 µM and >100 µM for PDE11 and PDE1-10, respectively. BC11-38 elevates cAMP levels, PKA-mediated ATF-1 phosphorylation, and cortisol production in H295R cells .
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PDE11-IN-1 is a PDE11 inhibitor and can be used for adrenal insufficiency research .
Cat. No.: HY-128060
CAS No.: 936449-28-4
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PDE5-IN-42 (Compound 42) is a potent and orally active PDE5 inhibitor with an IC50 of 0.04 nM. PDE5-IN-42 maintains selectivity over PDE6 and PDE11 .
Cat. No.: HY-156434
CAS No.: 3027607-92-4
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PDE11A4-IN-1 is a selective, cell-permeable inhibitor of phosphodiesterase 11A4 (PDE11A4) with an IC50 of 12 nM. PDE11A4-IN-1 inhibits PDE11A4-mediated hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) to the same extent. PDE11A4-IN-1 can be used in the research of age-related cognitive decline .
Cat. No.: HY-170435
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PDE5-IN-13 (Compound 14b) inhibits phosphodiesterase 5 (PDE5A) with an IC50 of 3 nM. PDE5-IN-13 is a potential candidate for PAH (pulmonary arterial hypertension) research. PDE5-IN-13 has high selectivity for targets over PDE1, PDE2, PDE3, PDE4, PDE7, PDE8, PDE9, PDE10, and PDE11. PDE5-IN-13 is orally active .
Cat. No.: HY-108618R
CAS No.: 686770-80-9
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BC11-38 (Standard) is the analytical standard of BC11-38 (HY-108618). This product is intended for research and analytical applications. BC11-38 is a potent, selective, and biologically active PDE11 inhibitor, with IC50s of 0.28 µM and >100 µM for PDE11 and PDE1-10, respectively. BC11-38 elevates cAMP levels, PKA-mediated ATF-1 phosphorylation, and cortisol production in H295R cells .
Cat. No.: HY-120195A
CAS No.: 2230054-75-6
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PF-04827736 (compound (S)-3) is a selective PDE1 inhibitor with IC50 values of 9.1 nM, 38 nM and 42 nM for PDE1B, PDE1C and PDE1A. PF-04827736 selectively inhibits human PDE1 over the other 10 superfamily members (PDE2-PDE11). PF-04827736 can be used for the study of cardiovascular disease .
Cat. No.: HY-162954
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SMQ-03-20 (compund 4g) is an orally bioavailable, brain-penetrant, selective and potent PDE11A4 inhibitor .
Cat. No.: HY-181589
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PDE11A4-IN-2 is a selective PDE11A4 inhibitor with an IC50 of 33 nM. PDE11A4-IN-2 functionally inhibits PDE11A4-mediated catalytic activities of cAMP and cGMP in cellular models. PDE11A4-IN-2 is applicable to the research of age-related cognitive decline .
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