2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. PDE11A4-IN-2

PDE11A4-IN-2 is a selective PDE11A4 inhibitor with an IC50 of 33 nM. PDE11A4-IN-2 functionally inhibits PDE11A4-mediated catalytic activities of cAMP and cGMP in cellular models. PDE11A4-IN-2 is applicable to the research of age-related cognitive decline.

For research use only. We do not sell to patients.

PDE11A4-IN-2

PDE11A4-IN-2 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

PDE11A4-IN-2 Related Antibodies

Top Publications Citing Use of Products

View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PDE11A4-IN-2 is a selective PDE11A4 inhibitor with an IC50 of 33 nM. PDE11A4-IN-2 functionally inhibits PDE11A4-mediated catalytic activities of cAMP and cGMP in cellular models. PDE11A4-IN-2 is applicable to the research of age-related cognitive decline[1].

IC50 & Target[1]

PDE11A4

33 nM (IC50)

In Vitro

PDE11A4-IN-2 (compound 15c) exhibits moderate stability in mouse liver microsomes with a half-life of 25 min[1].
PDE11A4-IN-2 (0.1-100 μM) concentration-dependently inhibits cAMP- and cGMP-mediated catalytic activity of PDE11A4 in mouse HT22 hippocampal neuron cells overexpressing PDE11A4, with EC50 values of 10.2 μM and 10.4 μM, respectively, and does not alter the protein level of PDE11A4[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PDE11A4-IN-2 Related Antibodies
Molecular Weight

430.48

Formula

C23H23FN8
SMILES

CN(N=C1)C=C1C2=CN(C3CCN(CC#N)CC3)C4=NC=NC(NC5=CC(F)=CC=C5)=C42
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

PDE11A4-IN-2 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PDE11A4-IN-2Phosphodiesterase (PDE)cGMPcAMPneuronal cellsHT22 cellsPDE11A4age-related cognitive declineInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
PDE11A4-IN-2
Cat. No.:
HY-181589
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.