PDE11A4-IN-2
PDE11A4-IN-2 is a selective PDE11A4 inhibitor with an IC50 of 33 nM. PDE11A4-IN-2 functionally inhibits PDE11A4-mediated catalytic activities of cAMP and cGMP in cellular models. PDE11A4-IN-2 is applicable to the research of age-related cognitive decline.
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- 화학식: C23H23FN8
- 분자량:430.48
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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PDE11A4 33 nM (IC50) |
PDE11A4-IN-2 (compound 15c) exhibits moderate stability in mouse liver microsomes with a half-life of 25 min[1].
PDE11A4-IN-2 (0.1-100 μM) concentration-dependently inhibits cAMP- and cGMP-mediated catalytic activity of PDE11A4 in mouse HT22 hippocampal neuron cells overexpressing PDE11A4, with EC50 values of 10.2 μM and 10.4 μM, respectively, and does not alter the protein level of PDE11A4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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분자량 430.48
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화학식 C23H23FN8
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SMILES
CN(N=C1)C=C1C2=CN(C3CCN(CC#N)CC3)C4=NC=NC(NC5=CC(F)=CC=C5)=C42
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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