PDE11A4-IN-2
PDE11A4-IN-2 is a selective PDE11A4 inhibitor with an IC50 of 33 nM. PDE11A4-IN-2 functionally inhibits PDE11A4-mediated catalytic activities of cAMP and cGMP in cellular models. PDE11A4-IN-2 is applicable to the research of age-related cognitive decline.
For research use only. We do not sell to patients.
- Formula: C23H23FN8
- Molecular Weight:430.48
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
PDE11A4 33 nM (IC50) |
PDE11A4-IN-2 (compound 15c) exhibits moderate stability in mouse liver microsomes with a half-life of 25 min[1].
PDE11A4-IN-2 (0.1-100 μM) concentration-dependently inhibits cAMP- and cGMP-mediated catalytic activity of PDE11A4 in mouse HT22 hippocampal neuron cells overexpressing PDE11A4, with EC50 values of 10.2 μM and 10.4 μM, respectively, and does not alter the protein level of PDE11A4[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Molecular Weight 430.48
-
Formula C23H23FN8
-
SMILES
CN(N=C1)C=C1C2=CN(C3CCN(CC#N)CC3)C4=NC=NC(NC5=CC(F)=CC=C5)=C42
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PDE11A4-IN-2 Related Classifications
HY-181589 Related Classifications
Powered by Bioz