PDE11A4-IN-1
PDE11A4-IN-1 is a selective, cell-permeable inhibitor of phosphodiesterase 11A4 (PDE11A4) with an IC50 of 12 nM. PDE11A4-IN-1 inhibits PDE11A4-mediated hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) to the same extent. PDE11A4-IN-1 can be used in the research of age-related cognitive decline.
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- CAS No.: 3027607-92-4
- Formule: C22H22F2N6O
- Masse moléculaire:424.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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PDE11A4 12 nM (IC50) |
PDE11A4-IN-1 (Compound 23b) (0.01-100 μM; 1 h) potently inhibits PDE11A4-mediated cAMP and cGMP hydrolysis in human PDE11A4-transfected HT-22 hippocampal cells with EC50 values of 2.5 μM and 2.1 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3027607-92-4
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Masse moléculaire 424.45
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Formule C22H22F2N6O
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SMILES
O=C(C1=C2C(N(N=C2C(F)F)C3=CC=CC=C3)=NC(C4=CC=NN4C)=C1)N(CC)CC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PDE11A4-IN-1 Related Classifications
HY-156434 Related Classifications
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