PDE11A4-IN-1
PDE11A4-IN-1 is a selective, cell-permeable inhibitor of phosphodiesterase 11A4 (PDE11A4) with an IC50 of 12 nM. PDE11A4-IN-1 inhibits PDE11A4-mediated hydrolysis of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) to the same extent. PDE11A4-IN-1 can be used in the research of age-related cognitive decline.
For research use only. We do not sell to patients.
- CAS No.: 3027607-92-4
- Formula: C22H22F2N6O
- Molecular Weight:424.45
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
PDE11A4 12 nM (IC50) |
PDE11A4-IN-1 (Compound 23b) (0.01-100 μM; 1 h) potently inhibits PDE11A4-mediated cAMP and cGMP hydrolysis in human PDE11A4-transfected HT-22 hippocampal cells with EC50 values of 2.5 μM and 2.1 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 3027607-92-4
-
Molecular Weight 424.45
-
Formula C22H22F2N6O
-
SMILES
O=C(C1=C2C(N(N=C2C(F)F)C3=CC=CC=C3)=NC(C4=CC=NN4C)=C1)N(CC)CC
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz