Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
radical mechanism
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "radical mechanism" in MCE Product Catalog:
Cat. No.: HY-W011956
CAS No.: 2208-41-5
Target:
Cat. No.: HY-W047187
CAS No.: 117405-51-3
Target:
Target:
Research Areas:
Propanedial (Malondialdehyde) (13.88 mM in water) is one of the final products of lipid peroxidation. Propanedial causes protein inactivation, DNA damage and cross-linking by forming stable covalent adducts with biological macromolecules, which is the main mechanism for its cytotoxicity and genotoxicity.
Propanedial production increases with the elevation of free radicals.
Propanedial is a key biomarker for evaluating the level of cellular oxidative stress [1][2][3].
Cat. No.: HY-W010610
CAS No.: 5239-82-7
Target:
Research Areas:
2-Cyclopropylacetic acid is a substrate. 2-Cyclopropylacetic acid can produce a ring-opening product, which serves as an important precursor for the preparation of fused-ring molecules .
Cat. No.: HY-G0004
CAS No.: 37519-14-5
Synonyms: 3-Hydroxyacetaminophen
Target:
Research Areas:
Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen) is a non-toxic metabolite and antioxidant of acetaminophen (HY-66005) with free radical scavenging activity. Acetaminophen metabolite 3-hydroxy-acetaminophen can reduce oxidative damage by exerting electron donation ability and antioxidant activity through phenolic hydroxyl groups. 3-hydroxy-acetaminophen can be used to study the toxicity mechanism and drug metabolism of acetaminophen .
Cat. No.: HY-N0435
CAS No.: 17429-69-5
Category:
Flavonols Flavonoids Neurological Disease Leguminosae Phenols Polyphenols Plants Disease Research Fields Astragalus altaicus Bunge
Target:
Cat. No.: HY-W013494R
CAS No.: 305-84-0
L-Carnosine also exhibits some antioxidant effects. The antioxidant mechanism of L-Carnosine is attributed to its chelating effect against metal ions, superoxide dismutase (SOD)-like activity, and ROS and free radicals scavenging ability .
Cat. No.: HY-W067572
CAS No.: 85202-17-1
Synonyms: (-)-Stobadine
Target:
Research Areas:
Stobadine is a potent antioxidant and prevents free radical induced alterations in ER membrane fluidity. Stobadine can be used for effective cardio- and neuroprotectants development based on antioxidant or free radical scavenging mechanisms of action .
Cat. No.: HY-W011956R
CAS No.: 2208-41-5
Cat. No.: HY-G0004R
CAS No.: 37519-14-5
Synonyms: 3-Hydroxyacetaminophen (Standard)
Target:
Research Areas:
Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen) (Standard) is the analytical standard of Acetaminophen metabolite 3-hydroxy-acetaminophen (HY-G0004). This product is intended for research and analytical applications. Acetaminophen metabolite 3-hydroxy-acetaminophen is a non-toxic metabolite and antioxidant of acetaminophen (HY-66005) with free radical scavenging activity. Acetaminophen metabolite 3-hydroxy-acetaminophen can reduce oxidative damage by exerting electron donation ability and antioxidant activity through phenolic hydroxyl groups. 3-hydroxy-acetaminophen can be used to study the toxicity mechanism and drug metabolism of acetaminophen .
Cat. No.: HY-172892
Target:
Research Areas:
PI3K-IN-59 (Compound 3d) is a PI3K inhibitor (IC50: 17.44 μM). PI3K-IN-59 has significant antiproliferative activity and exhibits potent inhibitory effects on breast cancer 4T1 cells (IC50: 3.70 μM) and colon cancer CT26 cells (IC50: 1.98 μM) as well as human breast cancer cells (IC50: 19.72 μM). PI3K-IN-59 exerts a dual anti-tumor mechanism by inhibiting PI3Kα enzymatic activity and triggering the Fenton reaction to generate hydroxyl radicals (•OH). PI3K-IN-59 shows promising anti-4T1 tumor effects and is suitable for synergistic targeting studies in breast and colon cancers .
Cat. No.: HY-E71453C
Target:
Research Areas:
23S rRNA (adenine2503-C2)-methyltransferase (EC 2.1.1.192) contains a [4Fe-4S] cluster and belongs to the "radical AdoMet" (radical SAM) family. It employs a radical-based mechanism to methylate the adenosine residue using a CH? group derived from S-adenosyl-L-methionine, while retaining the hydrogen atom at the C-2 position of adenosine 2503 in the 23S rRNA.
Cat. No.: HY-D3401
CAS No.: 3121511-17-6
Target:
Research Areas:
LHA585 is a fluorescent probe targeting the lipid hydrogen abstraction process for the early detection of ferroptosis (Ferroptosis). Its detection mechanism relies on the reactivity of its own 4-phenyl-3-methylbut-2-enyl moiety with biologically relevant oxidative radicals, including peroxyl radicals (ROO·), alkoxyl radicals (RO·), hydroxyl radicals (HO·), and peroxynitrite anions (ONOO−); upon hydrogen abstraction from this structure, radical rearrangement and radical cleavage occur, releasing a xanthene radical which converts into a highly fluorescent rhodamine dye in biological environments, thereby achieving a fluorescence turn-on ratio of up to 360-fold. LHA585 is non-fluorescent in its native state, possesses excellent membrane permeability due to its non-polar property, and the rhodamine dye generated after oxidation diffuses into mitochondria. The excitation wavelength of LHA585 is 561 nm, and its emission wavelength ranges from 570 to 620 nm .
Cat. No.: HY-189001
PROTEC NAMPT Degrader-1 is a NAMPT PROTEC degrader. PROTEC NAMPT Degrader-1 binds to NAMPT via non-covalent interactions and degrades this protein through a proximity-induced radical oxidation mechanism mediated by cyclopropane radical clock, independent of proteasomal or lysosomal pathways. PROTEC NAMPT Degrader-1 exhibits anticancer activity against ovarian cancer. It can be used in relevant studies on ovarian cancer (Pink: NAMPT ligand: (HY-188123); Linker: (HY-188124)) .
Cat. No.: HY-N9799
CAS No.: 1013909-91-5
Cat. No.: HY-181436
CAS No.: 940952-42-1
Target:
Research Areas:
CAY10563 is a pH-regulated NO donor. Under acidic conditions, CAY10563 releases NO via an acid-catalyzed ring-opening mechanism, generating sulfur-centered free radicals. CAY10563 induces pH-dependent vasodilation. CAY10563 can be used in studies related to cardiovascular and cerebrovascular diseases .
Cat. No.: HY-N17779
CAS No.: 173658-86-1
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
