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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
rapid eye movement sleep
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "rapid eye movement sleep" in MCE Product Catalog:
4
4 Cited Publications
Synonyms: JNJ-42847922
Target:
Research Areas:
Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective orexin-2 receptor (OX2R) antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain .
4
4 Cited Publications
Synonyms: JNJ-42847922 hydrochloride
Target:
Research Areas:
Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain .
1
1 Cited Publications
Synonyms: RG7090; RO4917523
Target:
Research Areas:
Basimglurant (RG7090; RO4917523) is a selective, orally active, blood-brain barrier permeable negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5), with a Ki of 1.4 nM (against [ 3H]-ABP688 (HY-110141)) and 35.6 nM (against [ 3H]-MPEP (HY-14609A)). Basimglurant inhibits mGlu5-mediated signaling pathways and receptor constitutive activity, regulates dopamine levels in the nucleus accumbens, exerts anxiolytic, antidepressant-like, analgesic and arousal-promoting effects, and alters δ-wave power during non-rapid eye movement sleep. Basimglurant can be used in research on depression, fragile X syndrome, anxiety disorders, etc .
Synonyms: BisfluoroModafinil; CRL-40940; NLS-4
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Research Areas:
Lauflumide (BisfluoroModafinil) is a selective dopamine reuptake inhibitor and wake-promoting agent. Lauflumide inhibits the dopamine transporter (DAT). Lauflumide induces sustained wakefulness without eliciting hyperlocomotion, stereotypy or abnormal behaviors in Mus musculus (house mice). Lauflumide reduces non-rapid eye movement (NREM) sleep rebound in rats, modulates electroencephalogram (EEG) spectral composition, and produces anti-aggressive effects. Lauflumide alleviates circadian rhythm disturbances in rats, increases spontaneous activity in fatigued rats, and facilitates their recovery from severe fatigue. Lauflumide can be used in research related to excessive daytime sleepiness as well as chronic severe fatigue/chronic fatigue syndrome (CFS) .
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MK-3697 is an orally active orexin 2 receptor (OX2R) antagonist, with an IC50 value of 16 nM and a Ki value of 1.1 nM against human OX2R. MK-3697 blocks the wake-promoting OX2R signaling pathway, reduces active wake time, and increases slow-wave sleep and rapid eye movement sleep time in mice, rats and dogs. MK-3697 can be used for research on insomnia .
Cat. No.: HY-168365
CAS No.: 26126-01-2
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(±)-Pellotine hydrochloride (Compound 2) is an alkaloid, which is found in L. diffusa and L. fricii. (±)-Pellotine hydrochloride decreases locomotor activity and the amount of rapid eye movement (REM) sleep in mice .
Cat. No.: HY-124492
CAS No.: 21489-22-5
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Prindamine is a noradrenaline transporter inhibitor with very weak anticholinergic and serotonin (5-HT) uptake inhibiting effects. Prindamine blocks noradrenaline uptake, increasing synaptic availability of noradrenaline in the brain. Prindamine decreases rapid eye movement sleep (REMS) in cats. Prindamine initially increases the proportion of time spent in active wakefulness in cats .
Cat. No.: HY-14856
CAS No.: 223445-75-8
Synonyms: PD 0200390
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Research Areas:
Atagabalin (PD 0200390) is a Voltage-gated Calcium channel α2δ subunit binder with an IC50 of 22 nM. Atagabalin regulates neurotransmitter release by inhibiting calcium influx at high neuronal firing rates. Atagabalin can be used in research related to sleep disorders .
Cat. No.: HY-109012AR
CAS No.: 1293284-49-7
Synonyms: JNJ-42847922 hydrochloride (Standard)
Research Areas:
Seltorexant hydrochloride (Standard) is the analytical standard of Seltorexant (hydrochloride) (HY-109012A). This product is intended for research and analytical applications. Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain .
Cat. No.: HY-109012R
CAS No.: 1293281-49-8
Synonyms: JNJ-42847922 (Standard)
Research Areas:
Seltorexant (Standard) is the analytical standard of Seltorexant (HY-109012). This product is intended for research and analytical applications. Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective orexin-2 receptor (OX2R) antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain .
Cat. No.: HY-186253
CAS No.: 3129653-69-3
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Research Areas:
TMEM175 agonist 1 is a TMEM175 agonist, with a human EC50 of 0.378 μM in FLIPR assays and a human EC50 of 0.886 μM in EP analyses. TMEM175 agonist 1 can be used in the research of Parkinson's disease, dementia with Lewy bodies, rapid eye movement sleep behavior disorder, amyotrophic lateral sclerosis, and lysosomal storage diseases .
Cat. No.: HY-186254
CAS No.: 3129652-92-9
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Research Areas:
TMEM175 agonist 2 is a TMEM175 agonist with an EC50 of 0.0446 μM in human FLIPR assays and an EC50 of 0.0453 μM in human TMEM175 EP assays. TMEM175 agonist 2 can be used in research related to Parkinson's disease, dementia with Lewy bodies, rapid eye movement sleep behavior disorder, amyotrophic lateral sclerosis, and lysosomal storage diseases .
Cat. No.: HY-186257
CAS No.: 3129652-66-7
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TMEM175 agonist 3 (Compound 123) is a TMEM175 agonist, with an EC50 of 0.044 μM in human TMEM175 FLIPR assays and an EC50 of 0.073 μM in human TMEM175 EP assays. TMEM175 agonist 3 can be used in the research of Parkinson's disease, dementia with Lewy bodies, rapid eye movement sleep behavior disorder, amyotrophic lateral sclerosis, and lysosomal storage diseases .
Cat. No.: HY-14856B
CAS No.: 223445-67-8
Synonyms: PD 0200390 hydrochloride
Target:
Research Areas:
Atagabalin hydrochloride (PD 0200390 hydrochloride) is a Voltage-gated Calcium channel α2δ subunit binder with an IC50 of 22 nM. Atagabalin hydrochloride regulates neurotransmitter release by inhibiting calcium influx at high neuronal firing rates. Atagabalin hydrochloride can be used in research related to sleep disorders .
Cat. No.: HY-114515
CAS No.: 1034442-21-1
Synonyms: RG7090 sulfate; RO4917523 sulfate
Target:
Research Areas:
Basimglurant (RG7090; RO4917523) sulfate is a selective, orally active, blood-brain barrier permeable negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5), with a Ki of 1.4 nM (against [ 3H]-ABP688 (HY-110141)) and 35.6 nM (against [ 3H]-MPEP (HY-14609A)). Basimglurant sulfate inhibits mGlu5-mediated signaling pathways and receptor constitutive activity, regulates dopamine levels in the nucleus accumbens, exerts anxiolytic, antidepressant-like, analgesic and arousal-promoting effects, and alters δ-wave power during non-rapid eye movement sleep. Basimglurant sulfate can be used in research on depression, fragile X syndrome, anxiety disorders, etc .
Cat. No.: HY-15446R
CAS No.: 802906-73-6
Synonyms: RG7090 (Standard); RO4917523 (Standard)
Target:
Research Areas:
Basimglurant (RG7090; RO4917523) (Standard) is the analytical standard of Basimglurant. This product is intended for research and analytical applications. Basimglurant is a selective, orally active, blood-brain barrier permeable negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5), with a Ki of 1.4 nM (against [ 3H]-ABP688 (HY-110141)) and 35.6 nM (against [ 3H]-MPEP (HY-14609A)). Basimglurant inhibits mGlu5-mediated signaling pathways and receptor constitutive activity, regulates dopamine levels in the nucleus accumbens, exerts anxiolytic, antidepressant-like, analgesic and arousal-promoting effects, and alters δ-wave power during non-rapid eye movement sleep. Basimglurant can be used in research on depression, fragile X syndrome, anxiety disorders, etc.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
