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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
rat HO-1
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "rat HO-1" in MCE Product Catalog:
4
Category:
Monophenols Simple Phenylpropanols Phenols Dicerothamnus rhinocerotis Phenylpropanoids Plants Umbelliferae
Target:
3
3 Cited Publications
Target:
Research Areas:
AM-1638 is an orally active full agonist of GPR40 (EC50: 0.16 μM). AM-1638 increases the expression of antioxidant molecules (HO-1 and NQO-1). AM1638 blocks Palmitate (HY-N0830)-mediated superoxide production and ER stress. AM-1638 has antidiabetic activity and improves glycemic control in BDF mice with diet-induced obesity (DIO). AM-1638 demonstrates excellent oral bioavailability (mouse, >100%; rat, 72%; and cyno, 71%) .
1
1 Cited Publications
Cat. No.: HY-N0807
CAS No.: 17388-39-5
Category:
other families Monophenols Metabolic Disease Phenols Zanthoxylum chiloperone var. angustifolium Plants Disease Research Fields Cancer
Target:
1
1 Cited Publications
Cat. No.: HY-W017370
CAS No.: 99-48-9
Cat. No.: HY-N6075
CAS No.: 449733-84-0
Synonyms: Nuezhenide
Cat. No.: HY-175660
Target:
Research Areas:
KCL-HO-1i is an orally active heme oxygenase-1 (HO-1) inhibitor (rat HO-1: IC50 = 123 nM) and human HO-1: IC50 = 128 nM). KCL-HO-1i targets immunosuppressive LYVE-1 + perivascular tumor-associated macrophages (PvTAMs) in the tumor microenvironment (TME), reduces PvTAM-mediated immune exclusion. KCL-HO-1i demonstrates synergistic anti-tumor efficacy with chemotherapy in MMTV-PyMT spontaneous breast cancer mice or C57Bl/6 mice bearing subcutaneous MN-MCA1 sarcomas. KCL-HO-1i can be used for the study of cancer .
Cat. No.: HY-W014422
CAS No.: 123333-71-1
Target:
Research Areas:
DL-Histidine hydrochloride hydrate is a heme oxygenase (HO) regulator, with no activity against rat spleen HO-1 and rat brain HO-2. DL-Histidine hydrochloride hydrate can be used in research on cancer and neurodegenerative diseases .
Cat. No.: HY-134310
CAS No.: 1353586-18-1
Target:
Research Areas:
QC-308 hydrochloride is a HO-1/HO-2 inhibitor, with an IC50 of 0.27 μM against rat HO-1 and an IC50 of 0.46 μM against rat HO-2. QC-308 hydrochloride inhibits the activities of rat HO-1 and HO-2 in carbon monoxide generation assays using spleen and brain microsomes, respectively. QC-308 hydrochloride also exhibits senolytic activity, reducing the survival rate of adipogenic progenitor cells in skeletal muscle fibers of senescent mice and human skeletal muscle myoblasts. QC-308 hydrochloride is applicable for senescence-related research .
Cat. No.: HY-182604
CAS No.: 1353712-58-9
Target:
Research Areas:
QC-308 is a HO-1/HO-2 inhibitor, with an IC50 of 0.27 μM against rat HO-1 and an IC50 of 0.46 μM against rat HO-2. QC-308 inhibits the activities of rat HO-1 and HO-2 in carbon monoxide generation assays using spleen and brain microsomes, respectively. QC-308 also exhibits senolytic activity, reducing the survival rate of adipogenic progenitor cells in skeletal muscle fibers of senescent mice and human skeletal muscle myoblasts. QC-308 is applicable for senescence-related research .
Cat. No.: HY-W017370R
CAS No.: 99-48-9
Cat. No.: HY-P706203
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Heme oxygenase 1; EC:1.14.14.18; HO-1; HSP32; Heme oxygenase 1 soluble form 1 publication; Hmox1
Species:
Rat
Source:
P. pastoris
Cat. No.: HY-N17651
CAS No.: 65618-21-5
Cat. No.: HY-N19615
CAS No.: 134859-90-8
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
