1353586-18-1
Chemical Structure
QC-308 hydrochloride
- CAS No.: 1353586-18-1
- Formula:C19H19ClN2O
- Molecular Weight:326.82
IUPAC Name: 1-(1H-imidazol-1-yl)-4,4-diphenylbutan-2-one hydrochloride
InChIKey: PDSITLPEDYABLQ-UHFFFAOYSA-N
SMILES: O=C(CC(C1=CC=CC=C1)C2=CC=CC=C2)CN3C=NC=C3.Cl
Biological Activity: QC-308 hydrochloride is a HO-1/HO-2 inhibitor, with an IC50 of 0.27 μM against rat HO-1 and an IC50 of 0.46 μM against rat HO-2. QC-308 hydrochloride inhibits the activities of rat HO-1 and HO-2 in carbon monoxide generation assays using spleen and brain microsomes, respectively. QC-308 hydrochloride also exhibits senolytic activity, reducing the survival rate of adipogenic progenitor cells in skeletal muscle fibers of senescent mice and human skeletal muscle myoblasts. QC-308 hydrochloride is applicable for senescence-related research[1][2].
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QC-308 hydrochloride | QC-308 hydrochloride is a HO-1/HO-2 inhibitor, with an IC50 of 0.27 μM against rat HO-1 and an IC50 of 0.46 μM against rat HO-2. QC-308 hydrochloride inhibits the activities of rat HO-1 and HO-2 in carbon monoxide generation assays using spleen and brain microsomes, respectively. QC-308 hydrochloride also exhibits senolytic activity, reducing the survival rate of adipogenic progenitor cells in skeletal muscle fibers of senescent mice and human skeletal muscle myoblasts. QC-308 hydrochloride is applicable for senescence-related research. | |||||||||||||||||||||
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