- Natural Products
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- Euphorbiaceae
- Euphorbia kansui T. N. Liou ex S. B. Ho
Euphorbia kansui T. N. Liou ex S. B. Ho
Alias: Kansui
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Euphorbia kansui T. N. Liou ex S. B. Ho (13)
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- Formula: C20H28O4
- Molecular Weight: 332.43
20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA).
August 31
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- Formula: C37H46O15
- Molecular Weight: 730.75
Kansuinine A is a diterpenoid compound. Kansuinine A is isolated from the roots of Euphorbia kansui. Kansuinine A inhibits H2O2-mediated upregulation of phosphorylated IKKβ, NF-κB and IκBα. Kansuinine A inhibits ROS production, reduces the Bax/Bcl-2 ratio and the expression of cleaved Caspase-3. Kansuinine A upregulates the expression of SOCS-3 and blocks IL-6-induced signal transduction. Kansuinine A decreases the expression of LOX-1 and inhibits Apoptosis. Kansuinine A reduces the atherosclerotic lesion area of the aortic arch, improves glucose/insulin tolerance, and enhances antioxidant capacity. Kansuinine A exhibits antiviral and antitumor activities. Kansuinine A can be used in research related to atherosclerosis, liver cancer and type 2 diabetes.
August 31
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- Formula: C29H34O6
- Molecular Weight: 478.58
Kansuiphorin C ameliorates malignant ascites by modulating gut microbiota and related metabolic functions.
August 31
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- Formula: C34H43NO11
- Molecular Weight: 641.71
3,5,7,15-Tetraacetoxy-9-nicotinoyloxy-6(17),11-jatrophadien-14-one is a Diterpenoids product that can be isolated from the roots of Euphorbia kansui..
August 31
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- Formula: C30H48O2
- Molecular Weight: 440.70
Kansenone, a euphane-type triterpene, can be isolated from a 60% EtOH extract of Euphorbia kansui.
August 31
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- Formula: C32H44O7
- Molecular Weight: 540.69
3-O-(2'E ,4'E-Decadienoyl)-20-O-acetylingenol is a ingenol-type diterpenoid that contains a 2,4-decadienoyloxy group.
August 31
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- Formula: C30H42O6
- Molecular Weight: 498.65
3-O-(2'E,4'Z-Decadienoyl)ingenol is a natural diterpene that exhibits significant anticomplement activity with an IC50 of 89.5 μM.
August 31
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- Formula: C30H42O6
- Molecular Weight: 498.65
3-O-(2'E,4'E-Decadienoyl)-ingenol is a natural diterpenoid that shows cytotoxicity against human normal cell lines L-O2 and GES-1, with IC50s of 8.22 μM and 6.67 μM, respectively.
August 31
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- Formula: C41H47NO14
- Molecular Weight: 777.81
Kansuinine E is a plant-derived nitric oxide inhibitor (IC50=6.3 μM). Kansuinine E belongs to jatrophane-type diterpenoids and is isolated from the roots of E. kansui.
August 31
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- Formula: C38H42O14
- Molecular Weight: 722.73
Kansuinine B is a natural diterpenoid compound with anti-inflammatory, anti-cancer and anti-viral activities, which can be isolated from the roots of Euphorbia kansui. Kansuinine B induces sustained ERK1/2 activation, inhibits IL-6-induced Stat3 activation and tyrosine phosphorylation, and enhances serine phosphorylation of Stat3. Kansuinine B negatively regulates the IL-6 signaling pathway by upregulating the expression of SOCS-3. Kansuinine B promotes the proliferation of mouse splenic lymphocytes in vitro and stimulates rat peritoneal macrophages to produce NO. Kansuinine B can be used in studies related to liver cancer and COVID-19.
August 31
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- Formula: C36H56O8
- Molecular Weight: 616.83
3-O-(2",3"-Dimethylbutanoyl)-13-O-decanoylingenol (compound 2) is a diterpenoid with antinematode activity, which can be isolated from Euphorbia kansui.
August 31
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- Formula: C32H44O7
- Molecular Weight: 540.69
3-O-(2'E ,4'Z-Decadienoyl)-20-O-acetylingenol (compound 6) is a diterpene that can be isolated from Euphorbia kansui. 3-O-(2'E ,4'Z-Decadienoyl)-20-O-acetylingenol shows cleavage inhibition activity of individual Xenopus cells at the blastular stage.
August 31
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- Formula: C27H32O5
- Molecular Weight: 436.54
5-O-Benzoyl-20-deoxyingenol is a diterpene that can be isolated from the roots of Euphorbia kansui. 5-O-Benzoyl-20-deoxyingenol inhibits cell proliferation.
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