7 Results for "

rat mesangial cells

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "rat mesangial cells" in MCE Product Catalog:

1
Sequoyitol
Sequoyitol
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1 Cited Publications
Cat. No.: HY-N2421
CAS No.: 523-92-2
Synonyms: 5-O-Methyl-myo-inositol
Category:  

Natural Products Leguminosae Glycine max (L.) merr Metabolic Disease Plants Disease Research Fields

Target:  

NF-κB TGF-β Receptor Reactive Oxygen Species (ROS) Insulin Receptor Akt Parasite

Sequoyitol (5-O-Methyl-myo-inositol) is an orally active hypoglycemic agent and antioxidant. Sequoyitol can be isolated from herbaceous plants. Sequoyitol downregulates the expression of NF-κB and TGF-β1, reduces ROS production and malondialdehyde levels, and enhances total antioxidant capacity. Sequoyitol activates the insulin signaling pathway, including the phosphorylation of IR, IRS1 and Akt. Sequoyitol increases serum insulin levels, inhibits hepatic glucose production, and promotes cellular glucose uptake. Sequoyitol antagonizes TNFα-induced inhibition of the insulin signaling pathway, and decreases blood urea nitrogen and serum creatinine levels. Sequoyitol elicits potential peaks in the chemosensors of adult and larval Atrophaneura alcinous, and acts as an oviposition stimulant for female Atrophaneura alcinous. Sequoyitol can be used in research related to type 2 diabetes, insulin resistance, hyperglycemia, impaired glucose tolerance and diabetic nephropathy .
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NSC 90469
NSC 90469
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Cat. No.: HY-114557
CAS No.: 1041-01-6
Purity:  99.38%
Synonyms: 3,5-Diiodo-L-thyronine
Category:  

Monophenols Ketones, Aldehydes, Acids Metabolic Disease Phenols Endogenous metabolite Disease Research Fields

Target:  

JNK NF-κB Sirtuin PGC-1α COX TGF-β Receptor Collagen

NSC 90469 (3,5-Diiodo-L-thyronine) is an orally active thyroid hormone derivative. NSC 90469 inhibits JNK phosphorylation and NF-κB acetylation, blocks SIRT1 protein expression, induces elevated PGC-1α levels, and stimulates COX activity. NSC 90469 enhances UCP1-mediated thermogenesis, increases hepatic Dio1 activity, inhibits TSH levels and hypothalamic-pituitary-thyroid axis function, enhances lipid metabolism, and regulates energy metabolism via the mitochondrial pathway. NSC 90469 prevents blood glucose reduction, reduces urinary albumin excretion, inhibits renal matrix expansion, decreases TGF-β1 expression, and reduces renal fibronectin and type Ⅳ collagen deposition. NSC 90469 also increases energy expenditure and prevents diet-induced overweight. NSC 90469 can be used in studies related to diabetic nephropathy, hypothyroidism, non-alcoholic fatty liver disease, and diet-induced obesity .
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ANP [Des18-22] 4-23 amide (rat)
ANP [Des18-22] 4-23 amide (rat)
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Cat. No.: HY-P1526
CAS No.: 111863-73-1
Target:  

Natriuretic Peptide Receptor (NPR)

Research Areas:  

Cardiovascular Disease

ANP [Des18-22] 4-23 amide rat is a polypeptide fragment of rat atrial natriuretic peptide (ANP) that specifically binds NPR-C .
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Prosaikogenin G
Prosaikogenin G
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Cat. No.: HY-N7665
CAS No.: 99365-23-8
Category:  

Triterpenes Terpenoids Metabolic Disease Plants Umbelliferae Disease Research Fields Carphephorus corymbosus (Nutt.) Torr. & A.Gray

Target:  

Others

Prosaikogenin G, isolated from the roots of Bupleurum chinensis DC., exhibits significant inhibitory effects on rat mesangial cell proliferation induced by Ang II. Prosaikogenin G has protective action on the kidney . Prosaikogenin G is a derivative of Saikosaponin d in the gastrointestinal tract .
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Isoeucommin A
Isoeucommin A
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Cat. No.: HY-N19615
CAS No.: 134859-90-8
Category:  

Natural Products Pandanus tonkinensis Martelli ex B. C. Stone Plants Pandanaceae

Target:  

Keap1-Nrf2 GSK-3 TNF Receptor Interleukin Related SOD

Isoeucommin A is a lignan compound. Isoeucommin A activates the Nrf2/HO-1 pathway and induces phosphorylation of GSK-3β. Isoeucommin A reduces the levels of pro-inflammatory cytokines TNF-α, IL-1β and IL-6, decreases the oxidative stress marker MDA, increases the antioxidants SOD and GSH, and alleviates oxidative stress in mesangial cells. Isoeucommin A alleviates renal tissue injury, improves impaired renal function and enhances the viability of renal tubular epithelial cells in diabetic nephropathy models. Isoeucommin A can be used in the research of diabetic nephropathy .
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CGP-43182
CGP-43182
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Cat. No.: HY-116192
CAS No.: 150379-37-6
Target:  

Phospholipase Interleukin Related NF-κB Prostaglandin Receptor NO Synthase

Research Areas:  

Inflammation/Immunology

CGP-43182 is a secretory phospholipase A2 group II (sPLA2) inhibitor with an IC50 of 2.8 μM. CGP-43182 binds to the active site of the enzyme, blocks IL1β-stimulated gene expression and NFκB activation, and inhibits the production of prostaglandin and nitric oxide (NO). CGP-43182 exhibits anti-inflammatory activity in multiple inflammatory models and can be used for studies on adjuvant arthritis, carrageenan-induced edema, pertussis pleurisy, and glomerular inflammatory responses .
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Lixazinone hydrogensulfate
Lixazinone hydrogensulfate
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Cat. No.: HY-113822
CAS No.: 101626-67-9
Synonyms: RS-82856 hydrogensulfate
Target:  

Phosphodiesterase (PDE)

Research Areas:  

Cardiovascular Disease Endocrinology

Lixazinone (RS-82856) hydrogensulfate is a selective inhibitor of cGMP-inhibited phosphodiesterase (PDE3) with an IC50 value of 22 nM. Lixazinone hydrogensulfate exhibits positive inotropic effects, afterload reduction and antithrombotic properties. Lixazinone hydrogensulfate increases cyclic adenosine monophosphate (cAMP) levels in human platelets, inhibits thrombin-induced aggregation of human platelets, and blocks the photolabeling of PDE3 active sites by [ 32P]cGMP. Lixazinone hydrogensulfate can be used in the research of polycystic kidney disease and congestive heart failure .
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