Search Result

Results for "

steroidal glycoside

" in MedChemExpress (MCE) Product Catalog:

標的別:	Amyloid-β (1) Apoptosis (1) Bacterial (1) Biochemical Assay Reagents (2) Calcium Channel (2) Drug Derivative (4) Drug Intermediate (1) Endogenous Metabolite (1) ERK (2) Glycosidase (2) Histone Demethylase (1) Isotope-Labeled Compounds (1) Na+/K+ ATPase (2) NF-κB (2) NO Synthase (2) PPAR (2) Reactive Oxygen Species (ROS) (2) Reference Standards (2) Xanthine Oxidase (1)
研究分野別:	Cancer (15) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (7) Metabolic Disease (5) Neurological Disease (2)

阻害剤およびアゴニスト

スクリーニングライブラリ

天然物

同位体標識化合物

製品番号	製品名	Target	研究分野	構造式

HY-N0515

Ophiopogonin D 1 Publications Verification	PPAR NF-κB Calcium Channel Reactive Oxygen Species (ROS) ERK	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Ophiopogonin D can be isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca ²⁺ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D can inhibit isteoclastic differentiation in RAW264.7 cells. Ophiopogonin D has protective effect as an antioxidant in H₂O₂-induced endothelial injury. Ophiopogonin D blocks ERK signaling cascades. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. Ophiopogonin D has been used against inflammatory, metabolic and cardiovascular diseases .

HY-129217

Naringinase 2 Publications Verification	Glycosidase	Others
Naringinase, a hydrolytic enzymatic complex, possesses the activity of both α-L-rhamnosidase and β-D-glucosidase. Naringinase has wide occurrence in nature. Naringinase can be used in the biotransformation of steroids, antibiotics, and mainly on glycosides hydrolysis .

HY-N1432

Lirioprolioside B	Others	Cancer
Lirioprolioside B is a steroidal glycoside that can be isolated from the underground organs of Liriope spicata var. prolifera .

HY-N1375

Qingyangshengenin	Others	Cancer
Qingyanshengenin (NSC 379666; compound 2), a pregnane glycoside, is a C21 steroidal aglycone isolated from the root of Cynanchumot ophyllum (Asclepiadaceae). Qingyanshengenin has anti-cancer activity .

HY-P2802B

α-Glucosidase, rice	Glycosidase	Metabolic Disease
α-Glucosidase, rice is a GH31 glycoside hydrolase in rice seeds, with high selectivity for α-1,4-glycosidic bonds. α-Glucosidase, rice can be inhibited by rice husk extracts (IC₅₀ = 1.25 μg/mL) and steroidal components (IC₅₀ = 1.83 μg/mL). α-Glucosidase, rice exists in two major isoforms, among which isoform II is more sensitive to inhibitors. α-Glucosidase, rice can directly bind to and degrade starch granules in rice seeds. α-Glucosidase, rice can form ONG2-I and ONG2-II via post-translational proteolysis. α-Glucosidase, rice can be used in type 2 diabetes research .

HY-N0515R

Ophiopogonin D (Standard)	Reference Standards PPAR NF-κB Calcium Channel ERK Reactive Oxygen Species (ROS)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Ophiopogonin D (Standard) is the analytical standard of Ophiopogonin D. This product is intended for research and analytical applications. Ophiopogonin D can be isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D can inhibit isteoclastic differentiation in RAW264.7 cells. Ophiopogonin D has protective effect as an antioxidant in H₂O₂-induced endothelial injury. Ophiopogonin D blocks ERK signaling cascades. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. Ophiopogonin D has been used against inflammatory, metabolic and cardiovascular diseases .

HY-N2175

Cixiophiopogon A	Others	Metabolic Disease
Cixiophiopogon A, a steroidal glycoside, obtained from the tuberous roots of Ophiopogon japonicus (Liliaceae) .

HY-N0582

Otophylloside B	Amyloid-β	Neurological Disease
Otophylloside B, a C-21 steroidal glycoside isolated from Qingyangshen. Otophylloside B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Otophylloside B has antiepileptic activity .

HY-N12380

Stauntoside M	Others	Others
Stauntoside M is a steroidal glycoside that can be isolated from the Roots of Cynanchum stauntonii .

HY-N8659

Uzarin Uzarigenin 3-β-sophoroside	Others	Others
Uzarin is a steroid glycoside. Uzarin does not inhibit cell proliferation or induce apoptosis .

HY-N12066

Progenin III palmitate	Others	Others
Progenin III palmitate is a steroid glycoside ester isolated from Dioscorea cayenensis rhizomes .

HY-107307

Ophiopojaponin A	Others	Others
Ophiopojaponin A is a steroidal glycoside that can be isolated from Polygonatum glaberrimum .

HY-N1217

Stauntosaponin A Stauntoside C	Na+/K+ ATPase	Cancer
Stauntosaponin A, a steroid glycoside, is a potent inhibitor of Na(+)/K(+)-ATPase with an IC₅₀ value of 21 nM. Stauntosaponin A can be isolated from Carnation and has potential anti-cancer research value .

HY-N12802

Tenacissimoside J	Others	Others
Tenacissimoside J is a steroid glycoside and can be isolated from Marsdenia tenacissima .

HY-N12724

Stauntoside R	Others	Others
Stauntoside R (compound 4) is a steroidal glycoside that can be isolated from the roots of Xu Changqing .

HY-N1962

Ophiopojaponin C	Others	Others
Ophiopojaponin C is a naturally occurring C₂₉ steroidal glycoside isolated from the tubers of O. japonicas .

HY-N0581

Qingyangshengenin A	Others	Neurological Disease
Qingyangshengenin A, a C-21 steroidal glycoside isolated from the roots of Cynanchum otophyllum Schneid, has antiepileptic activity .

HY-N12816

Glaucogenin C 3-O-α-L-cymaropyranosyl-(1→4)–β-D-digitoxopyranosyl-(1→4)-β-D-canaropyranoside	Others	Others
Glaucogenin C 3-O-α-L-cymaropyranosyl-(1→4)–β-D-digitoxopyranosyl-(1→4)-β-D-Canaropyranoside is a steroidal glycoside and can be isolated from Cynanchum stauntonii .

HY-N11912

Soladulcoside A	Biochemical Assay Reagents	Cancer
Soladulcoside A is a steroidal glycoside and antineoplastic agent that can be obtained from the whole plant of Solanum nigrum. Soladulcoside A can inhibit A549 cells and has the potential to study cancers such as non-small cell lung cancer (NSCLC) .

HY-N12720

Cynanoside J	Others	Cancer
Cynanoside J is a C₂₁ steroidal glycosides that can be obtained from Cynanchum taihangense. The IC₅₀ values of Cynanoside J for HL-60, THP1, and Caco2 are 6.38, 5.82, and 6.76 μM, respectively. Cynanoside J can be used in cancer research .

HY-N12817

Anti-inflammatory agent 80	NO Synthase	Inflammation/Immunology Cancer
Anti-inflammatory agent 80 (Compound 2/2f) is an anti-inflammatory agent and has anti-tumor activity. Anti-inflammatory agent 80 can be isolated fromCynanchum limprichtiiSchltr .

HY-N6061

Ophiopogonin C 1 Publications Verification	Others	Cancer
Ophiopogonin C, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin C shows cytotoxic activity against two human tumor cell lines MG-63 and SNU387 with IC₅₀s of 19.76 μM and 15.51 μM, respectively .

HY-N12002

Diosgenin-3-O-rhamnosyl(1→2)[glucosyl(1→6)]glucoside	Others	Others
Diosgenin-3-O-rhamnosyl(1→2)[glucosyl(1→6)]glucoside (compound 9) is a steroidal saponin, which can be obtained from Paris polyphylla var., Yunnan pine (yunnanensis) Isolated .

HY-W755679

Digitoxigenin-21,23,23-d3 Cerberigenin-d₃; Echujetin-d₃	Isotope-Labeled Compounds Biochemical Assay Reagents	Others
Digitoxigenin-21,23,23-d₃ (Cerberigenin-d₃; Echujetin-d₃) is the deuterium labeled Digitoxigenin (HY-B2151). Digitoxigenin is a steroid derivative commonly found in various plants, especially the foxglove plant (Digitalis purpurea). Digitoxigenin has unique chemical properties that make it an important precursor for the synthesis of cardiac glycosides, a group of drugs used to improve heart failure and certain types of arrhythmias. It works by inhibiting the sodium potassium ATPase pump, thereby increasing the force and efficiency of cardiac contractions.

HY-129236

Hellebrin	Na+/K+ ATPase Apoptosis	Cancer
Hellebrin is a bufadienolide compound extracted from plants that can inhibit tumor cell growth. Hellebrigenin shows potential in overcoming cancer cells' resistance to apoptosis stimuli and has also demonstrated anti-proliferation effects in multidrug-resistant (MDR) cancer cell models. Hellebrin can act on Na+/K+-ATPase to regulate intracellular signaling pathways .

HY-113038AR

α-Hydroxyglutaric acid disodium (Standard) 2-Hydroxyglutarate disodium (Standard); 2-Hydroxyglutaric acid disodium (Standard); 2-Hydroxypentanedioic acid disodium (Standard)	Reference Standards Histone Demethylase Endogenous Metabolite	Cancer
Ophiopogonin D (Standard) is the analytical standard of Ophiopogonin D. This product is intended for research and analytical applications. Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside . Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years .

HY-N9385

Proprotogracillin	Others	Others
Proprotogracillin is a steroidal glycoside isolated from the bulbs of lilium speciosum .

HY-N19129

Macrostemonoside E	Others	Others
Macrostemonoside E is a steroidal glycoside present in Allium macrostemon Bunge, which inhibits ADP-induced aggregation of human platelets in vitro (IC₅₀=0.417 mM) .

HY-N18046

Otophylloside Q	Drug Derivative	Cancer
Otophylloside Q is a pregnane glycoside (C-21 steroidal glycoside) isolated from the roots of Cynanchum otophyllum. With caudatin (HY-N1983), an anticancer agent, as its aglycone, Otophylloside Q contains a sugar chain composed of cymarose, oleandrose and glucose units .

HY-N18305

β-Sitosterol 3-O-galactopyranoside	Drug Intermediate	Others
β-Sitosterol 3-O-galactopyranoside is a steroidal glycoside that can be found in the leaves of Hibiscus sabdariffa .

HY-N19714

Aspacochinoside N	Drug Derivative	Inflammation/Immunology
Aspacochinoside N is a pregnane glycoside (steroidal saponin) found in the roots of Asparagus cochinchinensis with an IC₅₀ > 100 μM for NO production inhibition. Aspacochinoside N can be used in research on neuroinflammation .

HY-N18393

Caudatin 3-O-β-D-glucopyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside	Others	Others
Caudatin 3-O-β-D-glucopyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside (compound 6) is a C-21 steroidal glycoside that can be isolated from the roots of Cynanchum otophyllum and Cynanchum caudatum .

HY-N19936

Qinyangshengenin-3-O-β-D-digitoxopyranoside	Drug Derivative	Cancer
Qinyangshengenin-3-O-β-D-digitoxopyranoside is a C₂₁ steroidal glycoside that can be found in the whole herb of Prunella vulgaris Linn. Qinyangshengenin-3-O-β-D-digitoxopyranoside can be used for research of leukemia and lung cancer .

HY-N18229

Hirundoside A	Others	Cancer
Hirundoside A is a steroidal glycoside found in the roots of Cynanchum stauntonii .

HY-N18006

Otophylloside C	Others	Others
Otophylloside C is a C21 steroidal glycoside compound found in the root of Gynostemma pentaphyllum .

HY-N19080

Smilax glabra extract	Bacterial	Infection Inflammation/Immunology Cancer
Smilax glabra extract possesses a variety of benefits, including anti-inflammatory, antioxidant, antibacterial, and anticancer properties. It contains numerous active ingredients, such as dihydroflavonol glycosides (e.g., asstebin and neo-asstebin), flavonol glycosides, and steroidal saponins, including smilax saponin.

HY-N9749

Qingyangshengenin 3-O-β-D-cymaropyranosyl-(1→4)-β-D-digitoxopyranoside	Drug Derivative	Others
Qingyangshengenin 3-O-β-D-cymaropyranosyl-(1→4)-β-D-digitoxopyranoside is a natural steroid.

HY-N19055

Asparagus racemosus extract	Others	Inflammation/Immunology
Asparagus racemosus extract, derived from the roots of Asparagus racemosus (also known as Satavali), contains bioactive components such as saponins, steroidal glycosides, polyphenols, vitamins, flavonoids, and alkaloids. Asparagus racemosus extract is renowned for its anti-inflammatory and immunomodulatory properties.

HY-N18228

Stauntoside Ⅱ	Others	Cancer
Stauntoside Ⅱ is a 14,15-secopregnane-type C21 steroidal glycoside found in the roots of Cynanchum stauntonii. Stauntoside Ⅱ does not exhibit cytotoxic activity against human colon, hepatoma, gastric, lung, and ovarian cancer cells .

HY-N17914

Smilaxchinoside A	Xanthine Oxidase	Metabolic Disease
Smilaxchinoside A is an orally active steroidal glycoside found in the roots of S. riparia. Smilaxchinoside A reduces serum uric acid levels and shows potent uricosuric activity. Smilaxchinoside A inhibits XOD activity and downregulates renal mURAT1 expression. Smilaxchinoside A can be used for the research of hyperuricemia .

HY-N19427

25S-Anguivioside XV	NO Synthase	Inflammation/Immunology Cancer
25S-Anguivioside XV (Compound 8) is a steroidal glycoside. 25S-Anguivioside XV is isolated from the unripe berries of Solanum nigrum L. 25S-Anguivioside XV inhibits LPS-induced NO production with an IC₅₀ of 49.35 μM. 25S-Anguivioside XV exhibits antiproliferative activity against hepatoma cells .

製品番号	製品名

HY-L021

Natural Product Library	4,974 compounds
Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Natural sources may lead to basic research on potential bioactive components for commercial development as lead compounds in drug discovery. Nature has been a source of medicinal agents for thousands of years, and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional medicine. With the development of new molecular targets, there is an increasing demand for novel molecular diversity for screening. Natural products will play a crucial role in meeting this demand through the continued investigation of world’s bio-diversity, much of which remains unexplored. MCE provides a unique collection of 4,974 natural compounds that contain Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

Natural Product Library

4,974 compounds

Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Natural sources may lead to basic research on potential bioactive components for commercial development as lead compounds in drug discovery.

Nature has been a source of medicinal agents for thousands of years, and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional medicine. With the development of new molecular targets, there is an increasing demand for novel molecular diversity for screening. Natural products will play a crucial role in meeting this demand through the continued investigation of world’s bio-diversity, much of which remains unexplored.

MCE provides a unique collection of 4,974 natural compounds that contain Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

HY-L021M

Natural Product and Natural Product-Like Compound Library	5,019 compounds
From the discovery of traditional Chinese medicine to modern antibiotics, natural products have played an important role in the drug development process. A review of all FDA-approved drugs shows that natural products and natural product-like compounds account for more than one-third of all approved drugs. Nearly half of that came from mammals, a quarter from microbes, and a quarter from plants. Over time, the proportion of microbial natural products and natural product derivatives in approved drugs has increased. Natural products have natural advantages in drug development and can be used as lead compounds in drug discovery for drug identification and mechanism research. MCE provides a unique collection of 5,019 natural compounds and natural product-like compounds that contain saccharides and glycosides, phenylpropanoids, quinones, flavonoids, terpenoids and glycosides, steroids, alkaloid, phenols, acids and aldehydes. Natural product and natural product-like compounds library is a useful tool for drug discovery that can be used for high-throughput screening (HTS) and high-content screening (HCS).

Natural Product and Natural Product-Like Compound Library

5,019 compounds

From the discovery of traditional Chinese medicine to modern antibiotics, natural products have played an important role in the drug development process. A review of all FDA-approved drugs shows that natural products and natural product-like compounds account for more than one-third of all approved drugs. Nearly half of that came from mammals, a quarter from microbes, and a quarter from plants. Over time, the proportion of microbial natural products and natural product derivatives in approved drugs has increased. Natural products have natural advantages in drug development and can be used as lead compounds in drug discovery for drug identification and mechanism research.

MCE provides a unique collection of 5,019 natural compounds and natural product-like compounds that contain saccharides and glycosides, phenylpropanoids, quinones, flavonoids, terpenoids and glycosides, steroids, alkaloid, phenols, acids and aldehydes. Natural product and natural product-like compounds library is a useful tool for drug discovery that can be used for high-throughput screening (HTS) and high-content screening (HCS).

HY-L021P

Natural Product Library Plus	6,181 compounds
Natural products are small molecules produced naturally by any organism including primary and secondary metabolites. Natural sources may lead to basic research on potential bioactive components for commercial development as lead compounds in drug discovery. Nature has been a source of medicinal agents for thousands of years, and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional medicine. With the development of new molecular targets, there is an increasing demand for novel molecular diversity for screening. Natural products will play a crucial role in meeting this demand through the continued investigation of world’s bio-diversity, much of which remains unexplored. MCE provides a unique collection of 6,181 natural compounds that contains Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library Plus, with more powerful screening capability, further complements Natural Product Library (HY-L021) by adding some compounds with low solubility or solution stability (Part B) to this library. All those supplementary are supplied in powder form.

Natural Product Library Plus

6,181 compounds

MCE provides a unique collection of 6,181 natural compounds that contains Saccharides and Glycosides, Phenylpropanoids, Quinones, Flavonoids, Terpenoids and Glycosides, Steroids, Alkaloid, Phenols, Acids and Aldehydes. Natural Product Library Plus, with more powerful screening capability, further complements Natural Product Library (HY-L021) by adding some compounds with low solubility or solution stability (Part B) to this library. All those supplementary are supplied in powder form.

HY-L163

FDA-Approved Traditional Chinese Medicine Active Compound Library	308 compounds
Traditional Chinese medicine provides abundant natural resources for medicinal compounds, which are often considered effective and safe for drug discovery. Traditional Chinese medicine is based on the principle of "multiple components, multiple targets, and multiple pathways", and naturally has multiple pharmacological effects. As herbal medicine, the secondary plant metabolites in Chinese herbal medicine play an important role in alleviating many diseases in Traditional medicine and folk use. Therefore, the identification of traditional Chinese medicine derived compounds is also an important process in drug development and a necessary factor in dissecting the overall mechanism of action of traditional Chinese medicine. FDA listed compounds have completed extensive preclinical and clinical studies, exhibiting good biological activity, safety, and bioavailability. MCE designs a unique collection of 308 FDA/EMA/NMPA/PMDA etc-approved traditional Chinese medicine active compounds, including flavonoids, polyphenols, alkaloids, terpenoids, and other structural types. It is a good tool for drug reuse and screening drugs from traditional Chinese medicine sources.

FDA-Approved Traditional Chinese Medicine Active Compound Library

308 compounds

Traditional Chinese medicine provides abundant natural resources for medicinal compounds, which are often considered effective and safe for drug discovery. Traditional Chinese medicine is based on the principle of "multiple components, multiple targets, and multiple pathways", and naturally has multiple pharmacological effects. As herbal medicine, the secondary plant metabolites in Chinese herbal medicine play an important role in alleviating many diseases in Traditional medicine and folk use. Therefore, the identification of traditional Chinese medicine derived compounds is also an important process in drug development and a necessary factor in dissecting the overall mechanism of action of traditional Chinese medicine. FDA listed compounds have completed extensive preclinical and clinical studies, exhibiting good biological activity, safety, and bioavailability.

MCE designs a unique collection of 308 FDA/EMA/NMPA/PMDA etc-approved traditional Chinese medicine active compounds, including flavonoids, polyphenols, alkaloids, terpenoids, and other structural types. It is a good tool for drug reuse and screening drugs from traditional Chinese medicine sources.

HY-L200

RO5 Drug-like Natural Product Library

2,817 compounds

Natural products are small molecular compounds that occur in nature and come from any organism, including primary and secondary metabolites. Natural products have potential biological activity and can be used as lead compounds for drug discovery. Nature has been a source of medicines for thousands of years, and a large number of drugs have been isolated from nature, many based on their use in traditional medicine. With the development of compound targets, there is an increasing need to screen for compound diversity. Through ongoing research into natural biodiversity, much of which remains to be exploited, natural products will play a key role in meeting this demand. The Lipinski rule of 5 is used to describe the drug-like properties of a molecule, molecules that adhere to the rule of 5 have higher drug potential. Based on MCE natural product library, MCE selects the molecules that obey the rule of 5, which makes the efficiency of drug screening higher.

MCE designs a unique collection of 2,817 RO5 drug-like natural products, which is an important tool for drug discovery.

HY-L065

Traditional Chinese Medicine Active Compound Library

3,248 compounds

Chinese herbal therapy is an important part of Traditional Chinese Medicine (TCM). It has been used for centuries in China, where herbs are considered fundamental therapy for many acute and chronic conditions. Many studies indicated TCM exerted an overall regulatory effect via multi-component and multi-target network. Active components from Traditional Chinese Medicine possess many medicinal properties such as antioxidant, anti-cancer, and anti-bacterial effects, which makes it an important source of new drugs. Nearly 200 modern medicines have been developed either directly or indirectly from the plants used as medicines in China. For example, artemisinin, used in multidrug resistant malaria, was first isolated from the Chinese herb Artemisia annua L. Today, scientists continue to identify compounds in Chinese herbal remedies that may be useful in the development of new therapeutic agents applicable in Western medicine.

MCE designs a unique collection of 3,248 active compounds of Chinese Herbal Medicines. MCE Traditional Chinese Medicine Active Compound Library is a useful tool for discovery new drugs from TCM.

製品番号	製品名	Category	Target	構造式

HY-N0515

Ophiopogonin D 1 Publications Verification	Ophiopogon japonicus (L. f.) Ker-Gawl. Cardiovascular Disease Liliaceae Classification of Application Fields Plants Disease Research Fields Steroids Source Classification	PPAR NF-κB Calcium Channel Reactive Oxygen Species (ROS) ERK
Ophiopogonin D can be isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca ²⁺ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D can inhibit isteoclastic differentiation in RAW264.7 cells. Ophiopogonin D has protective effect as an antioxidant in H₂O₂-induced endothelial injury. Ophiopogonin D blocks ERK signaling cascades. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. Ophiopogonin D has been used against inflammatory, metabolic and cardiovascular diseases .

HY-129217

Naringinase 2 Publications Verification	Structural Classification 天然物 Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Source Classification	Glycosidase
Naringinase, a hydrolytic enzymatic complex, possesses the activity of both α-L-rhamnosidase and β-D-glucosidase. Naringinase has wide occurrence in nature. Naringinase can be used in the biotransformation of steroids, antibiotics, and mainly on glycosides hydrolysis .

HY-N1432

Lirioprolioside B	other families Classification of Application Fields Plants Disease Research Fields Steroids Source Classification Cancer	Others
Lirioprolioside B is a steroidal glycoside that can be isolated from the underground organs of Liriope spicata var. prolifera .

HY-N1375

Qingyangshengenin	Monophenols Classification of Application Fields Asclepiadaceae Phenols Cynanchum otophyllum Schneid． Plants Disease Research Fields Steroids Cancer Source Classification	Others
Qingyanshengenin (NSC 379666; compound 2), a pregnane glycoside, is a C21 steroidal aglycone isolated from the root of Cynanchumot ophyllum (Asclepiadaceae). Qingyanshengenin has anti-cancer activity .

HY-N0515R

Ophiopogonin D (Standard)	Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Plants Steroids Source Classification	Reference Standards PPAR NF-κB Calcium Channel ERK Reactive Oxygen Species (ROS)
Ophiopogonin D (Standard) is the analytical standard of Ophiopogonin D. This product is intended for research and analytical applications. Ophiopogonin D can be isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D can inhibit isteoclastic differentiation in RAW264.7 cells. Ophiopogonin D has protective effect as an antioxidant in H₂O₂-induced endothelial injury. Ophiopogonin D blocks ERK signaling cascades. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. Ophiopogonin D has been used against inflammatory, metabolic and cardiovascular diseases .

HY-N2175

Cixiophiopogon A	Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Classification of Application Fields Metabolic Disease Plants Disease Research Fields Steroids Source Classification	Others
Cixiophiopogon A, a steroidal glycoside, obtained from the tuberous roots of Ophiopogon japonicus (Liliaceae) .

HY-N0582

Otophylloside B	Neurological Disease Classification of Application Fields Anti-aging Asclepiadaceae Cynanchum otophyllum Schneid． Plants Disease Research Fields Steroids Source Classification	Amyloid-β
Otophylloside B, a C-21 steroidal glycoside isolated from Qingyangshen. Otophylloside B protects against Aβ toxicity, which decreases Aβ deposition by decreasing the expression of Aβ at the mRNA level. Otophylloside B has antiepileptic activity .

HY-N12380

Stauntoside M	Apocynaceae Structural Classification 天然物 Plants Vincetoxicum stauntonii (Decne.) C. Y. Wu et D. Z. Li Source Classification	Others
Stauntoside M is a steroidal glycoside that can be isolated from the Roots of Cynanchum stauntonii .

HY-N8659

Uzarin Uzarigenin 3-β-sophoroside	Structural Classification Cucurbitaceae Plants Bolbostemma paniculatum (Maxim.) Franquet Steroids Source Classification	Others
Uzarin is a steroid glycoside. Uzarin does not inhibit cell proliferation or induce apoptosis .

HY-N12066

Progenin III palmitate	Cardiacglycosides Plants Dioscorea cayenensis Lam. Steroids Source Classification Dioscoreaceae	Others
Progenin III palmitate is a steroid glycoside ester isolated from Dioscorea cayenensis rhizomes .

HY-107307

Ophiopojaponin A	Polygonatum glaberrimum K.Koch Plants Steroids Source Classification Asparagaceae Juss.	Others
Ophiopojaponin A is a steroidal glycoside that can be isolated from Polygonatum glaberrimum .

HY-N1217

Stauntosaponin A Stauntoside C	Apocynaceae Plants Vincetoxicum stauntonii (Decne.) C. Y. Wu et D. Z. Li Steroids Source Classification	Na+/K+ ATPase
Stauntosaponin A, a steroid glycoside, is a potent inhibitor of Na(+)/K(+)-ATPase with an IC₅₀ value of 21 nM. Stauntosaponin A can be isolated from Carnation and has potential anti-cancer research value .

HY-N12802

Tenacissimoside J	Cardiacglycosides Marsdenia tenacissima (Roxb.) Moon Asclepiadaceae Plants Steroids Source Classification	Others
Tenacissimoside J is a steroid glycoside and can be isolated from Marsdenia tenacissima .

HY-N12724

Stauntoside R	Apocynaceae Cardiacglycosides Plants Vincetoxicum stauntonii (Decne.) C. Y. Wu et D. Z. Li Steroids Source Classification	Others
Stauntoside R (compound 4) is a steroidal glycoside that can be isolated from the roots of Xu Changqing .

HY-N1962

Ophiopojaponin C	Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Classification of Application Fields Other Diseases Plants Disease Research Fields Steroids Source Classification	Others
Ophiopojaponin C is a naturally occurring C₂₉ steroidal glycoside isolated from the tubers of O. japonicas .

HY-N0581

Qingyangshengenin A	Monophenols Asclepiadaceae Phenols Cynanchum otophyllum Schneid． Plants Steroids Source Classification	Others
Qingyangshengenin A, a C-21 steroidal glycoside isolated from the roots of Cynanchum otophyllum Schneid, has antiepileptic activity .

HY-N12816

Glaucogenin C 3-O-α-L-cymaropyranosyl-(1→4)–β-D-digitoxopyranosyl-(1→4)-β-D-canaropyranoside	Apocynaceae Plants Saccharides Vincetoxicum stauntonii (Decne.) C. Y. Wu et D. Z. Li Monosaccharides Source Classification	Others
Glaucogenin C 3-O-α-L-cymaropyranosyl-(1→4)–β-D-digitoxopyranosyl-(1→4)-β-D-Canaropyranoside is a steroidal glycoside and can be isolated from Cynanchum stauntonii .

HY-N11912

Soladulcoside A	Solanum nigrum Linn. Plants Solanaceae Steroids Source Classification	Biochemical Assay Reagents
Soladulcoside A is a steroidal glycoside and antineoplastic agent that can be obtained from the whole plant of Solanum nigrum. Soladulcoside A can inhibit A549 cells and has the potential to study cancers such as non-small cell lung cancer (NSCLC) .

HY-N12720

Cynanoside J	Apocynaceae Cardiacglycosides Plants Vincetoxicum atratum (Bunge) Morren et Decne. Steroids Source Classification	Others
Cynanoside J is a C₂₁ steroidal glycosides that can be obtained from Cynanchum taihangense. The IC₅₀ values of Cynanoside J for HL-60, THP1, and Caco2 are 6.38, 5.82, and 6.76 μM, respectively. Cynanoside J can be used in cancer research .

HY-N12817

Anti-inflammatory agent 80	Apocynaceae Cardiacglycosides Vincetoxicum forrestii (Schltr.) C. Y. Wu & D. Z. Li Plants Steroids Source Classification	NO Synthase
Anti-inflammatory agent 80 (Compound 2/2f) is an anti-inflammatory agent and has anti-tumor activity. Anti-inflammatory agent 80 can be isolated fromCynanchum limprichtiiSchltr .

HY-N6061

Ophiopogonin C 1 Publications Verification	Ophiopogon japonicus (L. f.) Ker-Gawl. Triterpenes Liliaceae Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification Cancer	Others
Ophiopogonin C, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside. Ophiopogonin C shows cytotoxic activity against two human tumor cell lines MG-63 and SNU387 with IC₅₀s of 19.76 μM and 15.51 μM, respectively .

HY-N12002

Diosgenin-3-O-rhamnosyl(1→2)[glucosyl(1→6)]glucoside	Structural Classification Plants Melanthiaceae Steroids Paris polyphylla var. yunnanensis (Franch.) Hand.-Mzt. Source Classification	Others
Diosgenin-3-O-rhamnosyl(1→2)[glucosyl(1→6)]glucoside (compound 9) is a steroidal saponin, which can be obtained from Paris polyphylla var., Yunnan pine (yunnanensis) Isolated .

HY-113038AR

α-Hydroxyglutaric acid disodium (Standard) 2-Hydroxyglutarate disodium (Standard); 2-Hydroxyglutaric acid disodium (Standard); 2-Hydroxypentanedioic acid disodium (Standard)	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Histone Demethylase Endogenous Metabolite
Ophiopogonin D (Standard) is the analytical standard of Ophiopogonin D. This product is intended for research and analytical applications. Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside . Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years .

HY-N9385

Proprotogracillin	Liliaceae Classification of Application Fields Other Diseases Plants Disease Research Fields Lilium brownie var. viridulum Steroids Source Classification	Others
Proprotogracillin is a steroidal glycoside isolated from the bulbs of lilium speciosum .

HY-N19129

Macrostemonoside E	Structural Classification 天然物 Allium macrostemon Bunge Plants Amaryllidaceae Source Classification	Others
Macrostemonoside E is a steroidal glycoside present in Allium macrostemon Bunge, which inhibits ADP-induced aggregation of human platelets in vitro (IC₅₀=0.417 mM) .

HY-N18046

Otophylloside Q	Apocynaceae Structural Classification Cynanchum otophyllum C. K. Schneid. Plants Steroids Source Classification	Drug Derivative
Otophylloside Q is a pregnane glycoside (C-21 steroidal glycoside) isolated from the roots of Cynanchum otophyllum. With caudatin (HY-N1983), an anticancer agent, as its aglycone, Otophylloside Q contains a sugar chain composed of cymarose, oleandrose and glucose units .

HY-N18305

β-Sitosterol 3-O-galactopyranoside	Malvaceae Structural Classification Hibiscus sabdariffa Linn. Plants Steroids Source Classification	Drug Intermediate
β-Sitosterol 3-O-galactopyranoside is a steroidal glycoside that can be found in the leaves of Hibiscus sabdariffa .

HY-N19714

Aspacochinoside N	Structural Classification Polysaccharides Asparagus cochinchinensis (Lour.) Merr. Plants Saccharides Asparagaceae Juss. Source Classification	Drug Derivative
Aspacochinoside N is a pregnane glycoside (steroidal saponin) found in the roots of Asparagus cochinchinensis with an IC₅₀ > 100 μM for NO production inhibition. Aspacochinoside N can be used in research on neuroinflammation .

HY-N18393

Caudatin 3-O-β-D-glucopyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside	Apocynaceae Structural Classification Tetracyclic Triterpenoids Cynanchum otophyllum C. K. Schneid. Terpenoids Plants Source Classification	Others
Caudatin 3-O-β-D-glucopyranosyl-(1→4)-β-D-oleandropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-β-D-cymaropyranoside (compound 6) is a C-21 steroidal glycoside that can be isolated from the roots of Cynanchum otophyllum and Cynanchum caudatum .

HY-N19936

Qinyangshengenin-3-O-β-D-digitoxopyranoside	Structural Classification Labiatae Plants Physostigma venenosum Balf. Steroids Source Classification	Drug Derivative
Qinyangshengenin-3-O-β-D-digitoxopyranoside is a C₂₁ steroidal glycoside that can be found in the whole herb of Prunella vulgaris Linn. Qinyangshengenin-3-O-β-D-digitoxopyranoside can be used for research of leukemia and lung cancer .

HY-N18229

Hirundoside A	Apocynaceae Structural Classification Plants Vincetoxicum stauntonii (Decne.) C. Y. Wu et D. Z. Li Steroids Source Classification	Others
Hirundoside A is a steroidal glycoside found in the roots of Cynanchum stauntonii .

HY-N18006

Otophylloside C	Apocynaceae Structural Classification Cynanchum otophyllum C. K. Schneid. Plants Steroids Source Classification	Others
Otophylloside C is a C21 steroidal glycoside compound found in the root of Gynostemma pentaphyllum .

HY-N19080

Smilax glabra extract	Structural Classification Extract	Bacterial
Smilax glabra extract possesses a variety of benefits, including anti-inflammatory, antioxidant, antibacterial, and anticancer properties. It contains numerous active ingredients, such as dihydroflavonol glycosides (e.g., asstebin and neo-asstebin), flavonol glycosides, and steroidal saponins, including smilax saponin.

HY-N9749

Qingyangshengenin 3-O-β-D-cymaropyranosyl-(1→4)-β-D-digitoxopyranoside	Apocynaceae Structural Classification Cynanchum otophyllum C. K. Schneid. Plants Steroids Source Classification	Drug Derivative
Qingyangshengenin 3-O-β-D-cymaropyranosyl-(1→4)-β-D-digitoxopyranoside is a natural steroid.

HY-N19055

Asparagus racemosus extract	Structural Classification Extract	Others
Asparagus racemosus extract, derived from the roots of Asparagus racemosus (also known as Satavali), contains bioactive components such as saponins, steroidal glycosides, polyphenols, vitamins, flavonoids, and alkaloids. Asparagus racemosus extract is renowned for its anti-inflammatory and immunomodulatory properties.

HY-N18228

Stauntoside Ⅱ	Apocynaceae Structural Classification Plants Vincetoxicum stauntonii (Decne.) C. Y. Wu et D. Z. Li Steroids Source Classification	Others
Stauntoside Ⅱ is a 14,15-secopregnane-type C21 steroidal glycoside found in the roots of Cynanchum stauntonii. Stauntoside Ⅱ does not exhibit cytotoxic activity against human colon, hepatoma, gastric, lung, and ovarian cancer cells .

HY-N17914

Smilaxchinoside A	Structural Classification Smilacaceae Smilax riparia A. DC. Plants Steroids Source Classification	Xanthine Oxidase
Smilaxchinoside A is an orally active steroidal glycoside found in the roots of S. riparia. Smilaxchinoside A reduces serum uric acid levels and shows potent uricosuric activity. Smilaxchinoside A inhibits XOD activity and downregulates renal mURAT1 expression. Smilaxchinoside A can be used for the research of hyperuricemia .

HY-N19427

25S-Anguivioside XV	Structural Classification Solanum nigrum Linn. Solanaceae Plants Steroids Source Classification	NO Synthase
25S-Anguivioside XV (Compound 8) is a steroidal glycoside. 25S-Anguivioside XV is isolated from the unripe berries of Solanum nigrum L. 25S-Anguivioside XV inhibits LPS-induced NO production with an IC₅₀ of 49.35 μM. 25S-Anguivioside XV exhibits antiproliferative activity against hepatoma cells .

製品番号	製品名	構造式

HY-W755679

Digitoxigenin-21,23,23-d3

Digitoxigenin-21,23,23-d₃ (Cerberigenin-d₃; Echujetin-d₃) is the deuterium labeled Digitoxigenin (HY-B2151). Digitoxigenin is a steroid derivative commonly found in various plants, especially the foxglove plant (Digitalis purpurea). Digitoxigenin has unique chemical properties that make it an important precursor for the synthesis of cardiac glycosides, a group of drugs used to improve heart failure and certain types of arrhythmias. It works by inhibiting the sodium potassium ATPase pump, thereby increasing the force and efficiency of cardiac contractions.

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