Art. -Nr.: HY-N0581

Qingyangshengenin A

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Qingyangshengenin A, a C-21 steroidal glycoside isolated from the roots of Cynanchum otophyllum Schneid, has antiepileptic activity.

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Reinheit: 99.25%
CAS. Nr.: 106644-33-1
Formel: C₄₉H₇₂O₁₇
Molecular Weight:933.09

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Qingyangshengenin A Chemical Structure

CAS. Nr.: 106644-33-1

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Qingyangshengenin A, a C-21 steroidal glycoside isolated from the roots of Cynanchum otophyllum Schneid, has antiepileptic activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>40 μM Compound: 15	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 29625825]
HL-60	IC₅₀	29.1 μM Compound: 15	Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human HL60 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 29625825]
MCF7	IC₅₀	>40 μM Compound: 15	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 29625825]
SMMC-7721	IC₅₀	>40 μM Compound: 15	Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human SMMC7721 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 29625825]
SW480	IC₅₀	>40 μM Compound: 15	Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human SW480 cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 29625825]

Chemical Information

CAS. Nr. 106644-33-1
Appearance Solid
Molecular Weight 933.09
Formel C₄₉H₇₂O₁₇
SMILES

C[C@@]([C@@H](C[C@]1([H])[C@]23C)OC(C4=CC=C(O)C=C4)=O)([C@]5(O)C(C)=O)[C@@]([C@@]1(CC=C2C[C@@H](O[C@@](O[C@H](C)[C@H]6O[C@@](O[C@H](C)[C@H]7O[C@@](O[C@H](C)[C@H]8O)([H])C[C@H]8OC)([H])C[C@@H]7OC)([H])C[C@@H]6OC)CC3)O)(CC5)O
Structure Classification
- Phenols
- Monophenols
- Steroids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (107.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.0717 mL

5.3585 mL

10.7171 mL

5 mM

0.2143 mL

1.0717 mL

2.1434 mL

10 mM

0.1072 mL

0.5359 mL

1.0717 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (2.68 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (2.68 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (2.68 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Mu QZ, et al. Two new antiepilepsy compounds--otophyllosides A and B. Sci Sin B. 1986 Mar;29(3):295-301. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.0717 mL	5.3585 mL	10.7171 mL	26.7927 mL
	5 mM	0.2143 mL	1.0717 mL	2.1434 mL	5.3585 mL
	10 mM	0.1072 mL	0.5359 mL	1.0717 mL	2.6793 mL
	15 mM	0.0714 mL	0.3572 mL	0.7145 mL	1.7862 mL
	20 mM	0.0536 mL	0.2679 mL	0.5359 mL	1.3396 mL
	25 mM	0.0429 mL	0.2143 mL	0.4287 mL	1.0717 mL
	30 mM	0.0357 mL	0.1786 mL	0.3572 mL	0.8931 mL
	40 mM	0.0268 mL	0.1340 mL	0.2679 mL	0.6698 mL
	50 mM	0.0214 mL	0.1072 mL	0.2143 mL	0.5359 mL
	60 mM	0.0179 mL	0.0893 mL	0.1786 mL	0.4465 mL
	80 mM	0.0134 mL	0.0670 mL	0.1340 mL	0.3349 mL
	100 mM	0.0107 mL	0.0536 mL	0.1072 mL	0.2679 mL

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Qingyangshengenin A

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Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Qingyangshengenin A

Natural Product Library

Lipid Compound Library

Phenols Library

Plant-Sourced Natural Product Library

Cuproptosis Compound Library

Heterocyclic Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Qingyangshengenin A Related Classifications

HY-N0581 Related Classifications