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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
tankyrase-1
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "tankyrase-1" in MCE Product Catalog:
5
5 Cited Publications
JW 55 is a potent and selective β-catenin signaling pathway inhibitor, which functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2). JW 55 decreases auto-PARsylation of TNKS1/2 in vitro with IC50s of 1.9 μM and 830 nM respectively.
3
1
1 Cited Publications
RK-287107 is a potent and specific tankyrase inhibitor with IC50s of 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively. RK-287107 blocks colorectal cancer cell growth [1].
Cat. No.: HY-137849
CAS No.: 2171388-28-4
RK-582 is a tankyrase inhibitor, antitumor agent, and orally bioavailable growth inhibitor, with an IC50 of 36.1 nM against human tankyrase-1 and an IC50 of 39.2 nM against human tankyrase-2. In APC-mutated colorectal cancer cells, the sensitivity to RK-582 correlates with the level of active β-catenin, while drug resistance associates with PIK3CA mutation. RK-582 can be used for the research of colorectal cancer [1] .
Synonyms: JPI-547/OCN-201
Research Areas:
Nesuparib (JPI-547) is the orally active inhibitor for PARP 1/2 and Tankyrase 1/2 that inhibits tankyrases 1, tankyrases 2, and PARP 1 with IC50s of 5, 1 and 2 nM, respectively. Nesuparib exhibits antitumor activity and can be used in research of advanced solid tumor [1] .
OM-153 is a potent and orally active tankyrase inhibitor with IC50s of 13 nM and 2 nM for tankyrase 1 and tankyrase 2 (TNKS1/2), respectively. OM-153 inhibits luciferase-based Wnt/β-catenin signaling reporter activity with an IC50 value of 0.63 nM. OM-153 shows inhibition of Wnt/β-catenin signaling and proliferation in COLO 320DM [1] .
Cat. No.: HY-152197
CAS No.: 938893-79-9
Tankyrase-IN-3 is a tankyrase 1 (TNKS1) inhibitor with an IC50 value of 22 nM. Tankyrase-IN-3 can be used for the research of cancer [1].
Cat. No.: HY-108516
CAS No.: 865565-29-3
TC-E 5001 is an inhibitor of Wnt pathway that inhibits tankyrase 1/2 (TNKS1/2) via novel adenosine pocket binding, with Kds of 79 nM and 28 nM, respectively. TC-E 5001 also inhibits Axin2 and STF, with IC50s of 0.709 μM and 0.215 μM, respectively [1] .
Cat. No.: HY-P701632
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNKS; ADP-Ribosyltransferase Diphtheria Toxin-Like 5; tankyrase; Poly [ADP-Ribose] Polymerase tankyrase-1; PARP5A; Poly [ADP-Ribose] Polymerase 5A; ARTD5; tankyrase-1; TNKS1; tankyrase I; TINF1; TNKS-1; TIN1; TANK1; PARP-5a; PARPL; PART5; TRF1-Interacting
Species:
Human
Source:
E. coli
Cat. No.: HY-P701631
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: TNKS; ADP-Ribosyltransferase Diphtheria Toxin-Like 5; tankyrase; Poly [ADP-Ribose] Polymerase tankyrase-1; PARP5A; Poly [ADP-Ribose] Polymerase 5A; ARTD5; tankyrase-1; TNKS1; tankyrase I; TINF1; TNKS-1; TIN1; TANK1; PARP-5a; PARPL; PART5; TRF1-Interacting
Species:
Human
Source:
E. coli
Cat. No.: HY-P87112
Synonyms: ADP-ribosyltransferase diphtheria toxin-like 5 antibody; OTTHUMP00000115550 antibody; OTTHUMP00000224675 antibody; PARP 5a antibody; PARP5A antibody; PARPL antibody; pART5 antibody; Poly [ADP-ribose] polymerase 5A antibody; TANK 1 antibody; TANK1 antibody; ADP-ribosyltransferase diphtheria toxin-like 5 antibody; OTTHUMP00000115550 antibody; OTTHUMP00000224675 antibody; PARP 5a antibody; PARP5A antibody; PARPL antibody; pART5 antibody; Poly [ADP-ribose] polymerase 5A antibody; TANK 1 antibody; TANK1 antibody; tankyrase 1 antibody; tankyrase I antibody; tankyrase TRF1 interacting ankyrin related ADP ribose polymerase antibody; tankyrase-1 antibody; tankyrase1 antibody; tankyraseI antibody; TIN 1 antibody; TIN1 antibody; TINF 1 antibody; TINF1 antibody; TNKS 1 antibody; TNKS antibody; TNKS-1 antibody; TNKS1 antibody; TNKS1_HUMAN antibody; TRF1 interacting ankyrin related ADP ribose polymerase antibody; TRF1-interacting ankyrin-related ADP-ribose polymerase antibody;
Cat. No.: HY-145584A
CAS No.: 2055357-65-6
Synonyms: JPI-547/OCN-201 hydrochloride
Nesuparib (JPI-547) hydrochloride is the orally active inhibitor for PARP 1/2 and Tankyrase 1/2 that inhibits tankyrases 1, tankyrases 2, and PARP 1 with IC50s of 5, 1 and 2 nM, respectively. Nesuparib hydrochloride exhibits antitumor activity and can be used in research of advanced solid tumor [1] .
Cat. No.: HY-183474
CAS No.: 37418-69-2
Synonyms: ZINC13406363
LZZ-02 (ZINC13406363) is an orally active Tankyrase 1/2 inhibitor. LZZ-02 reduces c-Myc levels and inhibits the transcriptional activity of the WNT/β-catenin pathway. LZZ-02 exhibits anticancer activity against colon cancer. LZZ-02 can be used in studies related to colorectal cancer [1] .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
