37418-69-2
37418-69-2
Chemical Structure
LZZ-02
Synonym(s): ZINC13406363
- CAS. Nr.: 37418-69-2
- Formula:C15H12N2O3
- Molecular Weight:268.27
InChIKey: YLVNYJXXPXCCHE-ZHACJKMWSA-N
SMILES: O=C(C1=CC=CC=C1)/C=C/NC2=CC=C(C=C2)[N+]([O-])=O
Biological Activity: LZZ-02 is an orally active Tankyrase 1/2 inhibitor. LZZ-02 reduces c-Myc levels and inhibits the transcriptional activity of the WNT/β-catenin pathway. LZZ-02 exhibits anticancer activity against colon cancer. LZZ-02 can be used in studies related to colorectal cancer[1][2][3].
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LZZ-02 | LZZ-02 is an orally active Tankyrase 1/2 inhibitor. LZZ-02 reduces c-Myc levels and inhibits the transcriptional activity of the WNT/β-catenin pathway. LZZ-02 exhibits anticancer activity against colon cancer. LZZ-02 can be used in studies related to colorectal cancer. | |||||||||||||||||||||
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References
- [1]. Pećina-Šlaus N, et al. Wnt Signaling Inhibitors and Their Promising Role in Tumor Treatment. International journal of molecular sciences. 2023 Apr 04;24(7):6733. [Content Brief]
- [2]. Li B, et al. Discovery of Novel Inhibitor for WNT/β-Catenin Pathway by Tankyrase 1/2 Structure-Based Virtual Screening. Molecules (Basel, Switzerland). 2020 Apr 06;25(7):1680. [Content Brief]
- [3]. Yu M, et al. Small-Molecule Inhibitors of Tankyrases as Prospective Therapeutics for Cancer. Journal of medicinal chemistry. 2022 Apr 14;65(7):5244-5273. [Content Brief]
Keywords
