2406278-81-5
Chemical Structure
OM-153
- CAS No.: 2406278-81-5
- Formula:C28H24FN7O2
- Molecular Weight:509.53
IUPAC Name: N-((1S,3r)-3-(5-(5-ethoxypyridin-2-yl)-4-(2-fluorophenyl)-4H-1,2,4-triazol-3-yl)cyclobutyl)quinoxaline-5-carboxamide
InChIKey: ARCOJIXZDJYBCH-IYARVYRRSA-N
SMILES: O=C(C1=C2N=CC=NC2=CC=C1)N[C@H]3C[C@H](C4=NN=C(C5=NC=C(OCC)C=C5)[N@]4[C@]6=CC=CC=C6F)C3
Biological Activity: OM-153 is a potent and orally active tankyrase inhibitor with IC50s of 13 nM and 2 nM for tankyrase 1 and tankyrase 2 (TNKS1/2), respectively. OM-153 inhibits luciferase-based Wnt/β-catenin signaling reporter activity with an IC50 value of 0.63 nM. OM-153 shows inhibition of Wnt/β-catenin signaling and proliferation in COLO 320DM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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OM-153 | 99.30% | OM-153 is a potent and orally active tankyrase inhibitor with IC50s of 13 nM and 2 nM for tankyrase 1 and tankyrase 2 (TNKS1/2), respectively. OM-153 inhibits luciferase-based Wnt/β-catenin signaling reporter activity with an IC50 value of 0.63 nM. OM-153 shows inhibition of Wnt/β-catenin signaling and proliferation in COLO 320DM. | ||||||||||||||||||||
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References
- [1]. Leenders RGG, et al. Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II. J Med Chem. 2021;64(24):17936-17949. [Content Brief]
- [2]. Shoshy A. Brinch, et al. The Tankyrase Inhibitor OM-153 Demonstrates Antitumor Efficacy and a Therapeutic Window in Mouse Models. Cancer Research Communications (2022) 2 (4): 233-245.
