4 Results for "

trans-signalling

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "trans-signalling" in MCE Product Catalog:

47
47 Cited Publications
Cat. No.: HY-P9917
CAS No.: 375823-41-9
Synonyms: Anti-Human IL6R, Humanized Antibody; RG-1569; rhPM-1
Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis . Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease) .
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1
1 Cited Publications
Cat. No.: HY-P990211

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Anti-Mouse IL-6R Antibody (15A7) is a rat-derived anti-mouse IL-6R IgG2b κ type antibody inhibitor. Anti-Mouse IL-6R Antibody (15A7) blocks IL-6 binding to IL-6Rα and inhibits both IL-6 classic and trans-signaling. Anti-Mouse IL-6R Antibody (15A7) can be used for the researches of cancer and inflammation, such as triple-negative breast cancer .
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Cat. No.: HY-P99012
CAS No.: 1236278-28-6
Synonyms: ALD-518; BMS-945429
Clazakizumab (ALD-518; BMS-945429) is a monoclonal antibody inhibitor targeting IL-6 that binds to and blocks IL-6-mediated signaling (including trans-signaling), reducing STAT3 phosphorylation, innate immune cell infiltration, endothelial activation, and complement activation, thereby protecting the kidney from ischemia-reperfusion injury. Clazakizumab can be used in research on renal ischemia-reperfusion injury and obesity-related hypercoagulability .
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Cat. No.: HY-P991602
Synonyms: TZLS-501

Target:  

Interleukin Related

Research Areas:  

Cancer

NI-1201 is a monoclonal antibody that targets, in the human IL-6R sequence, the epitope recognized by 25F10 for mice. NI-1201 inhibits both IL-6 cis- and trans-signaling. NI-1201 targets site IIb of hIL-6R. NI-1201 inhibits gp130 binding to IL-6R .
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