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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
23 Results for "
transcription 3
" in MedChemExpress (MCE) Product Catalog:
Products (23)
23 Results for "transcription 3" in MCE Product Catalog:
8
8 Publications Verification
STAT3-IN-3 is a potent and selective inhibitor of signal transducer and activator of transcription 3 (STAT3), with anti-proliferative activity. STAT3-IN-3 induces apoptosis in breast cancer cells. STAT3-IN-3 acts as a promising mitochondria-targeting STAT3 inhibitor for cancer research .
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MNK8 is a potent STAT3 (signal transducer and activator of transcription 3) inhibitor. MNK8 inhibits STAT3 activation and reduced its DNA binding ability. MNK8 shows good growth inhibition against hepatocellular carcinoma (HCC) cells. MNK8 induces apoptosis in HCC cells. MNK8 reduces prosurvival proteins expression and migration/invasion of HCC cells .
Cat. No.: HY-172767
STAT3-D11-PROTAC-VHL (Compound D11-PROTAC) is a PROTAC degrader targeting Signal Transducer and Activator of Transcription 3 (STAT3). STAT3-D11-PROTAC-VHL exhibits anti-tumor activity with IC50 values of 1335 nM and 1973 nM against HeLa and MCF-7 cells, respectively. STAT3-D11-PROTAC-VHL binds to the DNA-binding domain of STAT3 and recruits the E3 ligase VHL to form a ternary complex, leading to the ubiquitination of STAT3 and subsequent degradation by the proteasome. STAT3-D11-PROTAC-VHL also inhibits tumor cell growth, induces cell cycle arrest and apoptosis, and suppresses tumor immune evasion .
Cat. No.: HY-175771
Target:
Research Areas:
STAT3-IN-46 is a selective and orally active inhibitor of signal transducer and activator of transcription 3 (STAT3) (KD = 323.3 nM). STAT3-IN-46 directly binds to the SH2 domain of the STAT3 and inhibits IL-6/JAK/STAT3 signaling pathway (IC50 = 0.87 μM) and downregulates c-Myc and Bcl-2 levels. STAT3-IN-46 can be used for the research of cancer, such as triple-negative breast cancer .
Cat. No.: HY-P70574
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: STAT3; Signal Transducer And Activator Of transcription; Signal Transducer And Activator Of transcription 3; DNA-Binding Protein APRF; APRF; ADMIO1; Acute-Phase Response Factor; ADMIO; Signal Transducer And Activator Of transcription 3 (Acute-Phase Respon
Species:
Human
Source:
E. coli
Cat. No.: HY-P701098
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: STAT3; Signal Transducer And Activator Of transcription; Signal Transducer And Activator Of transcription 3; DNA-Binding Protein APRF; APRF; ADMIO1; Acute-Phase Response Factor; ADMIO; Signal Transducer And Activator Of transcription 3 (Acute-Phase Respon
Species:
Human
Source:
E. coli
Cat. No.: HY-P704899
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: STAT3; Signal Transducer And Activator Of transcription; Signal Transducer And Activator Of transcription 3; DNA-Binding Protein APRF; APRF; ADMIO1; Acute-Phase Response Factor; ADMIO; Signal Transducer And Activator Of transcription 3 (Acute-Phase Respon
Species:
Human
Source:
E. coli
Cat. No.: HY-161351
STAT3/AKT-IN-1 is a dual inhibitor for the signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT) signalling pathway, exhibits antitumor activity against gastric cancer and induces cell apoptosis in SGC-7901 cells .
Cat. No.: HY-P86737
Synonyms: STAT3(phospho Y705); p-STAT3(phospho Y705); phospho-Stat3(pTyr705); STAT3(phospho-Tyr705); p-STAT3(Tyr705); phosphorylated Stat3(pTyr705); p-Stat3; Acute Phase Response Factor; APRF; DNA binding protein APRF; FLJ20882; MGC16063; Signal Transductor and Activator of transcription 3; STAT 3; STAT3_HUMAN.
Cat. No.: HY-P86737A
Synonyms: STAT3(phospho Y705); p-STAT3(phospho Y705); phospho-Stat3(pTyr705); STAT3(phospho-Tyr705); p-STAT3(Tyr705); phosphorylated Stat3(pTyr705); p-Stat3; Acute Phase Response Factor; APRF; DNA binding protein APRF; FLJ20882; MGC16063; Signal Transductor and Activator of transcription 3; STAT 3; STAT3_HUMAN.
Cat. No.: HY-100602R
CAS No.: 1420290-99-8
Target:
Research Areas:
HJC0152 (Standard) is the analytical standard of HJC0152 (HY-100602). This product is intended for research and analytical applications. HJC0152 is a signal transducers and activators of transcription 3 (STAT3) inhibitor.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
