2055078-49-2
2055078-49-2
Chemical Structure
MNK8
- CAS No.: 2055078-49-2
- Formula:C15H12N2O2
- Molecular Weight:252.27
IUPAC Name: 3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione
InChIKey: SJRMGNRXVMMJSY-UHFFFAOYSA-N
SMILES: O=C1N(C)C(C=C(C2=C3C=CC=CC3=CC=C2)N1)=O
Biological Activity: MNK8 is a potent STAT3 (signal transducer and activator of transcription 3) inhibitor. MNK8 inhibits STAT3 activation and reduced its DNA binding ability. MNK8 shows good growth inhibition against hepatocellular carcinoma (HCC) cells. MNK8 induces apoptosis in HCC cells. MNK8 reduces prosurvival proteins expression and migration/invasion of HCC cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MNK8 | 99.81% | MNK8 is a potent STAT3 (signal transducer and activator of transcription 3) inhibitor. MNK8 inhibits STAT3 activation and reduced its DNA binding ability. MNK8 shows good growth inhibition against hepatocellular carcinoma (HCC) cells. MNK8 induces apoptosis in HCC cells. MNK8 reduces prosurvival proteins expression and migration/invasion of HCC cells. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.60
HY-116474Viridicatol -
Similarity Score 0.60
HY-145820Tubulin inhibitor 14 -
Similarity Score 0.60
HY-167762TNKS-2-IN-4 -
Similarity Score 0.60
HY-W965550Apoptosis inducer 40 -
Similarity Score 0.59
HY-W472153β-Glucuronidase-IN-5 -
Similarity Score 0.59
HY-121889FQ -
Similarity Score 0.59
HY-168897LC3B ligand 1 -
Similarity Score 0.59
HY-125060Viridicatin -
Similarity Score 0.59
HY-17491Proquazone -
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