7 Results for "

transglycosylases

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "transglycosylases" in MCE Product Catalog:

1
Queuine
Queuine
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1 Cited Publications
Cat. No.: HY-N10574
CAS No.: 72496-59-4
Category:  

Alkaloids Microorganisms Pyrrole Alkaloids

Target:  

Bacterial

Queuine is a selective substrate for tRNA guanine transglycosylase (TGT) and can be incorporated into eukaryotic tRNA. Queuine promotes tRNA modification, affecting mitochondrial function and Warburg metabolic phenotype. If Queuine is deficient, aerobic glycolysis can be enhanced, oxidative phosphorylation can be inhibited, and Warburg metabolism can be promoted, accompanied by increased ammonia and lactate production and increased lactate dehydrogenase activity. Queuine can be used for autoimmune diseases (such as experimental models of multiple sclerosis) and cancer metabolic regulation, and its deficiency is associated with low tRNA modification in tumor cells .
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1
Queuine dihydrochloride
Queuine dihydrochloride
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1 Cited Publications
Cat. No.: HY-N10574A
CAS No.: 86496-18-6
Category:  

Alkaloids Microorganisms Pyrrole Alkaloids

Target:  

Others

Queuine dihydrochloride is a selective substrate for tRNA guanine transglycosylase (TGT) and can be incorporated into eukaryotic tRNA. Queuine dihydrochloride promotes tRNA modification, affecting mitochondrial function and Warburg metabolic phenotype. If Queuine dihydrochloride is deficient, aerobic glycolysis can be enhanced, oxidative phosphorylation can be inhibited, and Warburg metabolism can be promoted, accompanied by increased ammonia and lactate production and increased lactate dehydrogenase activity. Queuine dihydrochloride can be used for autoimmune diseases (such as experimental models of multiple sclerosis) and cancer metabolic regulation, and its deficiency is associated with low tRNA modification in tumor cells .
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Moenomycin complex
Moenomycin complex
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Cat. No.: HY-126387
CAS No.: 11015-37-5
Purity:  ≥99.0%
Target:  

Bacterial Antibiotic Penicillin-binding protein (PBP)

Research Areas:  

Infection

Moenomycin complex is a class of antibacterial agents and PBP inhibitors, with Kd values ranging from 94 nM to 1690 nM against various bacterial PBPs. Moenomycin complex inhibits bacterial growth by blocking the transglycosylase activity of class A penicillin-binding proteins (PBPs). Moenomycin complex is used in the research of bacterial infections .
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Sulfo-cyanine3 azide sodium
Sulfo-cyanine3 azide sodium
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Cat. No.: HY-D1274A
CAS No.: 2055138-89-9
Sulfo-cyanine3 azide sodium a water-soluble azide cyanine dye and fluorescent probe (Ex/Em=548/563 nm). Sulfo-cyanine3 azide sodium can be involved in synthesis of fused tricyclic heterocycles, produces immunostimulatory agents . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
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PreQ1-biotin
PreQ1-biotin
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Cat. No.: HY-171041
CAS No.: 2971850-25-4
Target:  

Bacterial

Research Areas:  

Others

PreQ1-biotin is a biotin conjugated preQ1 substrate. PreQ1-biotin is used for RNA-TAG (transglycosylation at guanosine) and DNA-TAG. PreQ1-biotin can be used for affinity tagging and pull-down of specific RNAs that have been modified selectively by E. coli tRNA guanine transglycosylase (TGT) .
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7-Cyano-7-deazaguanine
7-Cyano-7-deazaguanine
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Cat. No.: HY-W003845
CAS No.: 69205-79-4
Category:  

Alkaloids Microorganisms Pyrrole Alkaloids

Target:  

Endogenous Metabolite Nucleoside Antimetabolite/Analog Drug Intermediate

7-Cyano-7-deazaguanine is a key purine precursor molecule in the 7-deazaguanine pathway. 7-Cyano-7-deazaguanine acts as a substrate for transglycosylases to participate in base exchange reactions, replacing native guanine in nucleic acids to generate 7-deazaguanine-modified DNA or tRNA; it can be catalyzed by QueC/ToyM to form the 7-amido-7-deazaguanine (ADG) intermediate for further involvement in subsequent biosynthesis. 7-Cyano-7-deazaguanine is applicable to studies related to translation regulation .
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PreQ1-DBCO
PreQ1-DBCO
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Cat. No.: HY-185423
Target:  

DNA/RNA Synthesis Biochemical Assay Reagents

Research Areas:  

Cardiovascular Disease

PreQ1-DBCO is a strained cyclooctyne commonly used in click chemistry. PreQ1-DBCO undergoes TGT-catalyzed guanine base exchange in DNA oligonucleotide stem-loops to replace guanine. PreQ1-DBCO functionalizes custom DNA oligonucleotide sequences. DBCO-modified DNA oligonucleotides are conjugated with azide peptides via strain-promoted azide-alkyne click chemistry (SPAAC). PreQ1-DBCO can be used in studies of hemophilia B (Christmas disease) .
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