69205-79-4
Chemical Structure
7-Cyano-7-deazaguanine
- CAS No.: 69205-79-4
- Formula:C7H5N5O
- Molecular Weight:175.15
IUPAC Name: 2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
InChIKey: FMKSMYDYKXQYRV-UHFFFAOYSA-N
SMILES: N#CC1=CNC(N=C(N)N2)=C1C2=O
Biological Activity: 7-Cyano-7-deazaguanine is a key purine precursor molecule in the 7-deazaguanine pathway. 7-Cyano-7-deazaguanine acts as a substrate for transglycosylases to participate in base exchange reactions, replacing native guanine in nucleic acids to generate 7-deazaguanine-modified DNA or tRNA; it can be catalyzed by QueC/ToyM to form the 7-amido-7-deazaguanine (ADG) intermediate for further involvement in subsequent biosynthesis. 7-Cyano-7-deazaguanine is applicable to studies related to translation regulation[1][2][3].
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7-Cyano-7-deazaguanine | 7-Cyano-7-deazaguanine is a key purine precursor molecule in the 7-deazaguanine pathway. 7-Cyano-7-deazaguanine acts as a substrate for transglycosylases to participate in base exchange reactions, replacing native guanine in nucleic acids to generate 7-deazaguanine-modified DNA or tRNA; it can be catalyzed by QueC/ToyM to form the 7-amido-7-deazaguanine (ADG) intermediate for further involvement in subsequent biosynthesis. 7-Cyano-7-deazaguanine is applicable to studies related to translation regulation. | |||||||||||||||||||||
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References
- [1]. de Crécy-Lagard V, et al. Biosynthesis and function of 7-deazaguanine derivatives in bacteria and phages. Microbiology and molecular biology reviews : MMBR. 2024 Mar 27;88(1):e0019923.
- [2]. Nelp MT, et al. A Single Enzyme Transforms a Carboxylic Acid into a Nitrile through an Amide Intermediate. Angewandte Chemie (International ed. in English). 2015 Sep 01;54(36):10627-9.
- [3]. Gedara SH, et al. 7-Deazaguanines in DNA: functional and structural elucidation of a DNA modification system. Nucleic acids research. 2023 May 08;51(8):3836-3854.
