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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
ultraviolet irradiation
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "ultraviolet irradiation" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-W111581
CAS No.: 13681-87-3
Synonyms: Diethyldithiocarbamic acid copper salt
Copper(II) diethyldithiocarbamate (Diethyldithiocarbamic acid copper salt) is a Copper(II) and diethyldithiocarbamate coordination polymer. Copper(II) diethyldithiocarbamate binds tightly to NPL4 and induces its aggregation, disrupting the p97-NPL4-UFD1 pathway. Copper(II) diethyldithiocarbamate causes ubiquitinated proteins accumulation and impairs waste proteins degradation, thus resulting in cell apoptosis. Copper(II) diethyldithiocarbamate inhibits tumor growth in MDA-MB-231 xenograft mice models. Copper(II) diethyldithiocarbamate can be used for the research of cancer, such as breast cancer .
Synonyms: LRCL 3794
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Benoxaprofen (LRCL 3794) is a nonsteroidal anti-inflammatory agent that blocks the biosynthesis of inflammatory mediators such as leukotrienes and prostaglandins by inhibiting 5-LOX, PGH2 synthase and cytochrome P-450. Benoxaprofen exhibits significant toxicity: it not only alters cellular redox status, uncouples oxidative phosphorylation and disrupts calcium ion homeostasis, but also causes liver injury through the formation of covalent adducts between its active metabolites and hepatic proteins. Benoxaprofen shows strong phototoxicity under ultraviolet irradiation, and induces erythrocyte lysis, mast cell degranulation and histamine release. Benoxaprofen is widely used in studies of urticaria and related phototoxic mechanisms .
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Menaquinone 9 is a naphthoquinone-type vitamin K and electron transport component produced by bacteria. Menaquinone 9 is an orally active analog of Vitamin K2 (HY-109569). Menaquinone 9 acts as an ultraviolet-sensitive, photooxidizable substrate that generates more polar photodegradation products under oxygen and ultraviolet irradiation. Menaquinone 9 binds to the αβ dimer of Escherichia coli nitrate reductase, supporting electron transport within the αβ subunit structure of the enzyme. Menaquinone 9 serves as a precursor for bone Menaquinone-4 (HY-B2156). Menaquinone 9 can be used in studies related to metabolic diseases .
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DM-Nitrophen is a photolabile caged calcium compound that acts as a calcium releaser. DM-Nitrophen binds Ca 2+ with high affinity and Mg 2+ with considerable affinity before photolysis. DM-Nitrophen releases Ca 2+ into the cytosol upon ultraviolet light irradiation. DM-Nitrophen induces calcium concentration pulses, triggers cytosolic calcium transients, promotes calcium-dependent exocytosis. DM-Nitrophen can be used for the research of calcium-dependent cellular processes .
Cat. No.: HY-158220
Synonyms: HAMA (MW 400 kDa)
Cat. No.: HY-W015205
CAS No.: 2240-25-7
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DM-Nitrophen tertasodium is a photolabile caged calcium compound that acts as a calcium releaser. DM-Nitrophen tertasodium binds Ca 2+ with high affinity and Mg 2+ with considerable affinity before photolysis. DM-Nitrophen tertasodium releases Ca 2+ into the cytosol upon ultraviolet light irradiation. DM-Nitrophen tertasodium induces calcium concentration pulses, triggers cytosolic calcium transients, promotes calcium-dependent exocytosis. DM-Nitrophen tertasodium can be used for the research of calcium-dependent cellular processes .
Cat. No.: HY-174569
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Human NFKB1 mRNA encodes the human nuclear factor kappa B subunit 1 (NFKB1) protein, a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection.
Cat. No.: HY-P4465
CAS No.: 103192-40-1
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Cat. No.: HY-131501R
CAS No.: 523-39-7
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Menaquinone 9 (Standard) is the analytical standard of Menaquinone 9 (HY-131501). This product is intended for research and analytical applications. Menaquinone 9 is a naphthoquinone-type vitamin K and electron transport component produced by bacteria. Menaquinone 9 is an orally active analog of Vitamin K2 (HY-109569). Menaquinone 9 acts as an ultraviolet-sensitive, photooxidizable substrate that generates more polar photodegradation products under oxygen and ultraviolet irradiation. Menaquinone 9 binds to the αβ dimer of Escherichia coli nitrate reductase, supporting electron transport within the αβ subunit structure of the enzyme. Menaquinone 9 serves as a precursor for bone Menaquinone-4 (HY-B2156). Menaquinone 9 can be used in studies related to metabolic diseases .
Cat. No.: HY-131501S
Cat. No.: HY-131501S1
Cat. No.: HY-13568R
CAS No.: 51234-28-7
Synonyms: LRCL 3794 (Standard)
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Benoxaprofen (Standard) is the analytical standard of Benoxaprofen. This product is intended for research and analytical applications. Benoxaprofen (LRCL 3794) is a nonsteroidal anti-inflammatory agent that blocks the biosynthesis of inflammatory mediators such as leukotrienes and prostaglandins by inhibiting 5-LOX, PGH2 synthase and cytochrome P-450. Benoxaprofen exhibits significant toxicity: it not only alters cellular redox status, uncouples oxidative phosphorylation and disrupts calcium ion homeostasis, but also causes liver injury through the formation of covalent adducts between its active metabolites and hepatic proteins. Benoxaprofen shows strong phototoxicity under ultraviolet irradiation, and induces erythrocyte lysis, mast cell degranulation and histamine release. Benoxaprofen is widely used in studies of urticaria and related phototoxic mechanisms .
Cat. No.: HY-W778179
CAS No.: 1329840-53-0
Synonyms: LRCL 3794-13C,d3
Cat. No.: HY-165466
CAS No.: 83960-29-6
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Azidothiorphan is an irreversible photoaffinity ligand and Endopeptidase 24.11 inhibitor, with a Ki value of 0.75 nM against Endopeptidase 24.11. Upon UV irradiation, Azidothiorphan binds to the active site of enkephalinase, resulting in irreversible loss of enzyme activity. Azidothiorphan produces long-lasting analgesic effects in mice. Azidothiorphan can be used in pain-related research .
Cat. No.: HY-N11732
CAS No.: 36375-21-0
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Cat. No.: HY-133240
CAS No.: 1109241-72-6
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trans-AzoTAB is a photoresponsive potassium/sodium/calcium channel modulator and DNA-binding agent. trans-AzoTAB undergoes trans-cis isomerization driven by light, with variable polarity and DNA affinity. trans-AzoTAB also enhances voltage-gated potassium currents and inhibits sodium and calcium currents in cardiomyocytes, thereby reducing spontaneous electrical activity and excitation conduction velocity. In addition, trans-AzoTAB induces compaction and frozen conformation of λ-phage DNA, and non-sequence-dependently inhibits transcription and translation processes in the dark; its activity can be reversed and restored by visible light after activation with ultraviolet irradiation. trans-AzoTAB can serve as a probe for two-photon optical regulation of myocardial excitability, and is used to construct photoresponsive interfacial polymer structures .
Cat. No.: HY-180985
Azo-PROTAC-4C-cis is a BCR-ABL PROTAC degrader, and its degradation efficiency of BCR-ABL is much lower than that of its trans isomer Azo-PROTAC-4C-trans (HY-180983). Azo-PROTAC-4C-cis is the product of the conformational transformation of Azo-PROTAC-4C-trans under ultraviolet (UV) light irradiation. Azo-PROTAC-4C-cis can be converted into highly active Azo-PROTAC-4C-trans under visible light, thereby initiating protein degradation. Azo-PROTAC-4C-cis can be used for the study of myeloid leukemia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
