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Results for "

von Willebrand factor (vWF)

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

2

Inhibitory Antibodies

2

Recombinant Proteins

2

Antibodies

6

Oligonucleotides

Cat. No. 상품명 Target 연구분야 Chemical Structure
  • HY-P99227
    Caplacizumab (His Tag)
    1 Publications Verification

    ALX-0681; ALX-0081

    		 Integrin Transmembrane Glycoprotein Cardiovascular Disease
    Caplacizumab (His Tag) is a humanized anti-von Willebrand factor (vWF) nanobody. Caplacizumab (His Tag) inhibits the binding of vWF with platelet glycoprotein (GP) Ibα. Caplacizumab (His Tag) inhibits the vWF-mediated platelet adhesion and prevents further microthrombi formation. Caplacizumab (His Tag) can be used for the research of thrombotic thrombocytopenic purpura (TTP) .
    Caplacizumab (His Tag)
  • HY-153999A
    Rondaptivon pegol sodium

    BT200 sodium

    		 Integrin Apoptosis Cardiovascular Disease Inflammation/Immunology
    Rondaptivon pegol (BT200) sodium is an aptamer targeting von Willebrand factor (VWF), with an EC50 of 33 nM in humans. Rondaptivon pegol sodium effectively alleviates acute myocardial ischemia-reperfusion injury in mice by inhibiting VWF activity, reducing microvascular obstruction, inflammatory responses and cardiomyocyte apoptosis (apoptosis). Rondaptivon pegol sodium inhibits the binding of VWF to platelet glycoprotein GPIb, thereby preventing arterial thrombosis in cynomolgus monkeys. Rondaptivon pegol sodium can be used in research related to arterial thrombosis, stroke, myocardial infarction and myocardial ischemia-reperfusion injury .
    Rondaptivon pegol sodium
  • HY-138053
    Ristocetin A sulfate

    Ristomycin III

    		 Antibiotic Cardiovascular Disease Infection
    Ristocetin A sulfate (Ristomycin III) is a glycopeptide antibiotic that binds to von Willebrand factor (VWF) and bacterial cell wall components. Ristocetin A sulfate interferes with the biosynthesis of bacterial peptidoglycan by inhibiting transpeptidation. As an inducer of platelet adhesion and aggregation, Ristocetin A sulfate drives conformational changes by binding to the A1 domain of VWF, thereby activating downstream signaling pathways and promoting cytoskeletal rearrangement. Ristocetin A sulfate not only enhances platelet adhesion and spreading on immobilized VWF, but also induces the formation of asymmetric dimers with anticooperativity between platelets and plasma VWF. Ristocetin A sulfate is widely used in studies related to thromboembolic diseases and bacterial infections .
    Ristocetin A sulfate
  • HY-153999
    Rondaptivon pegol

    BT200

    		 Integrin Apoptosis Cardiovascular Disease Inflammation/Immunology
    Rondaptivon pegol (BT200) is an aptamer targeting von Willebrand factor (VWF), with an EC50 of 33 nM in humans. Rondaptivon pegol effectively alleviates acute myocardial ischemia-reperfusion injury in mice by inhibiting VWF activity, reducing microvascular obstruction, inflammatory responses and cardiomyocyte apoptosis (apoptosis). Rondaptivon pegol inhibits the binding of VWF to platelet glycoprotein GPIb, thereby preventing arterial thrombosis in cynomolgus monkeys. Rondaptivon pegol can be used in research related to arterial thrombosis, stroke, myocardial infarction and myocardial ischemia-reperfusion injury .
    Rondaptivon pegol
  • HY-147079A
    Egaptivon pegol sodium

    ARC 1779 sodium

    		 Integrin Cardiovascular Disease
    Egaptivon pegol sodium is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol sodium has anti-thrombotic efficacy.
    Egaptivon pegol sodium
  • HY-147079
    Egaptivon pegol

    ARC 1779

    		 Integrin Cardiovascular Disease
    Egaptivon pegol (ARC1779) is an aptamer, which blocks binding of the von Willebrand Factor (VWF) to platelet GPIb receptors. Egaptivon pegol has anti-thrombotic efficacy.
    Egaptivon pegol
  • HY-138019
    SP-8008

    		Integrin Cardiovascular Disease
    SP-8008 is a selective shear stress-induced platelet aggregation (SIPA) inhibitor with an IC50 of 1.44 μM. SP-8008 effectively interferes von Willebrand factor (vWF) and platelet glycoprotein (GP) Ib interaction. SP-8008 exerts its antithrombotic effect by selectively inhibiting shear stress-induced platelet aggregation .
    SP-8008
  • HY-153998
    BT100 sodium

    		Integrin Cardiovascular Disease
    BT100 (sodium), a aptamer, inhibits binding of von Willebrand factor (VWF) to platelet glycoprotein GPIb, preventing arterial thrombosis .
    BT100 sodium

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