SN 6 (Standard)
SN 6 (Standard) is the analytical standard of SN 6 (HY-107658). This product is intended for research and analytical applications. SN 6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor, and inhibits 45Ca2+ uptake by NCX1, NCX2, and NCX3, with IC50s of 2.9, 16, and 8.6 μM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 415697-08-4
- Formula: C20H22N2O5S
- Molecular Weight:402.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-107658
SN 6Na+/Ca2+ Exchanger Inhibitor -
HY-15754
CGP37157Na+/Ca2+ Exchanger Inhibitor -
HY-15415
KB-R7943 mesylateNCXrev Inhibitor -
HY-15515
SEA0400Na+/Ca2+ Exchanger Inhibitor -
HY-B1546A
Benzamil hydrochlorideENaC Blocker -
HY-123785
ORM-10962NCX Inhibitor -
HY-15515R
SEA0400 (Standard)Na+/Ca2+ Exchanger Inhibitor -
HY-128678
ORM-10103Na+/Ca2+ Exchanger Inhibitor -
HY-107659
YM-244769 hydrochlorideNCX Inhibitor -
HY-136182
YM-244769 dihydrochlorideNCX Inhibitor -
HY-100298
CaldaretCa2+ Handling Modulator -
HY-136182A
YM-244769NCX Inhibitor
Biological Activity
Description
IC50 & Target
IC50：2.9 μM (NCX1), 16 μM (NCX2), 8.6 μM (NCX3)[1]
Chemical Information
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CAS No. 415697-08-4
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Molecular Weight 402.46
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Formula C20H22N2O5S
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SMILES
CCOC(C(CS1)NC1CC2=CC=C(OCC3=CC=C([N+]([O-])=O)C=C3)C=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Ca2+ Staining Technique
Ca2+ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca2+ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.
Purity & Documentation
References
[1]. Iwamoto T, et al. The exchanger inhibitory peptide region-dependent inhibition of Na+/Ca2+ exchange by SN-6 [2-[4-(4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester], a novel benzyloxyphenyl derivative. Mol Pharmacol. 2004 Jul;66(1):45-55. [Content Brief]
[2]. Niu CF, et al. Electrophysiological effects of SN-6, a novel Na+/Ca2+ exchange inhibitor on membrane currents in guinea pig ventricular myocytes. Ann N Y Acad Sci. 2007 Mar;1099:534-9. [Content Brief]
[3]. Kita S, et al. Inhibitory mechanism of SN-6, a novel benzyloxyphenyl Na+/Ca2+ exchange inhibitor. Ann N Y Acad Sci. 2007 Mar;1099:529-33. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SN 6 (Standard) Related Classifications
HY-107658R Related Classifications
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