2. PROTAC Protein Tyrosine Kinase/RTK
  3. SNIPERs Bcr-Abl
  4. SNIPER(ABL)-039

SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively.

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SNIPER(ABL)-039

SNIPER(ABL)-039 Chemische Struktur

CAS. Nr. : 2222354-29-0

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SNIPER(ABL)-039 Related Antibodies

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Beschreibung

SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively[1].

IC50 & Target[1]

Abl

0.54 nM (IC50)

cIAP1

10 nM (IC50)

cIAP2

12 nM (IC50)

XIAP

50 nM (IC50)

SNIPER

 

Abl

10 nM (DC50)

Cellular Effect
Cell Line Type Value Description References
K562 DC50
>=3 nM
Compound: 4; SNIPER(ABL)-39
Protac activity at BCR-ABL/XIAP in human K562 cells assessed as induction of ABL protein degradation after 6 hrs by Western blot analysis
Protac activity at BCR-ABL/XIAP in human K562 cells assessed as induction of ABL protein degradation after 6 hrs by Western blot analysis
[PMID: 31047748]
Molekulargewicht

1114.77

Formel

C54H68ClN11O9S2
CAS. Nr.
SMILES

CC1=C(NC(C2=CN=C(NC3=CC(N4CCN(C(COCCOCCOCCOC5=CC(C(C6=CSC([C@H]7N(C([C@H](C8CCCCC8)NC([C@H](C)NC)=O)=O)CCC7)=N6)=O)=CC=C5)=O)CC4)=NC(C)=N3)S2)=O)C(Cl)=CC=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

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Reinheit & Dokumentation
Verweise
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SNIPER(ABL)-039 Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SNIPER(ABL)-0392222354-29-0SNIPERsBcr-AblPROTACs, IAP-dependent Protein Eraser, Specific and Nongenetic inhibitor of apoptosis protein [IAP]-dependent Protein ErasersInhibitorinhibitorinhibit

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