2. Immunology/Inflammation
  3. SphK
  4. SphK1&2-IN-1

SphK1&2-IN-1 is a SphK inhibitor targeting to SphK1 and SphK2. SphK1&2-IN-1 has thermal stability.

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SphK1&2-IN-1

SphK1&2-IN-1 화학구조

CAS No. : 1415662-57-5

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
5 mg 해외재고보유
10 mg 해외재고보유
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

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SphK1&2-IN-1 Related Antibodies

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SphK1 SphK2

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

SphK1&2-IN-1 is a SphK inhibitor targeting to SphK1 and SphK2. SphK1&2-IN-1 has thermal stability[1][2].

IC50 & Target[1]

SphK1

 

SphK2

 

In Vitro

SphK1&2-IN-1 (compound 40) (10 μM) inhibits SphK1 and SphK2 with inhibition rates of 14.3% and 26.5%, respectively[1].
SphK1&2-IN-1 (compound W4) (1-100 μM) has good thermal stability[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SphK1&2-IN-1 Related Antibodies
분자량

290.34

화학식

C14H14N2O3S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

COC1=C(C=CC(/C=C/C(NC2=NC=CS2)=O)=C1)OC
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

용액&용해도
In Vitro: 

DMSO : 31.25 mg/mL (107.63 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4442 mL 17.2212 mL 34.4424 mL
5 mM 0.6888 mL 3.4442 mL 6.8885 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4442 mL 17.2212 mL 34.4424 mL 86.1059 mL
5 mM 0.6888 mL 3.4442 mL 6.8885 mL 17.2212 mL
10 mM 0.3444 mL 1.7221 mL 3.4442 mL 8.6106 mL
15 mM 0.2296 mL 1.1481 mL 2.2962 mL 5.7404 mL
20 mM 0.1722 mL 0.8611 mL 1.7221 mL 4.3053 mL
25 mM 0.1378 mL 0.6888 mL 1.3777 mL 3.4442 mL
30 mM 0.1148 mL 0.5740 mL 1.1481 mL 2.8702 mL
40 mM 0.0861 mL 0.4305 mL 0.8611 mL 2.1526 mL
50 mM 0.0689 mL 0.3444 mL 0.6888 mL 1.7221 mL
60 mM 0.0574 mL 0.2870 mL 0.5740 mL 1.4351 mL
80 mM 0.0431 mL 0.2153 mL 0.4305 mL 1.0763 mL
100 mM 0.0344 mL 0.1722 mL 0.3444 mL 0.8611 mL
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SphK1&2-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SphK1&2-IN-11415662-57-5SphKSphingosine kinaseInhibitorinhibitorinhibit

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Inquiry Information

상품명:
SphK1&2-IN-1
Cat. No.:
HY-148707
수량:
MCE Japan Authorized Agent:

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