TTA-P2 (Synonyms: T-Type calcium channel inhibitor)

Cat. No.: HY-10035 Purity: 99.92% ee.: 100%: FAQs
Data Sheet SDS COA Handling Instructions

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TTA-P2 (T-Type calcium channel inhibitor) is a potent inhibitor of T-Type calcium channel. TTA-P2 penetrates well the CNS and blocks the native T-type currents in deep cerebellar nuclear neurons, the window current is completely abolished both for wild-type and mutant Cav3.1 channels. TTA-P2 has the potential for the research of neurology disease.

For research use only. We do not sell to patients.

TTA-P2 Chemical Structure

CAS No. : 1072018-68-8

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 598	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 598	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 630	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1070	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of TTA-P2:

(R)-TTA-P2 In-stock
(Rac)-TTA-P2 In-stock

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Description

Molecular Weight

431.37

Formula

C₂₁H₂₉Cl₂FN₂O₂

CAS No.

1072018-68-8

Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(C)(OCC1)C[C@H]1CN2CCC(F)(CC2)CNC(C3=CC(Cl)=CC(Cl)=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (57.95 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3182 mL	11.5910 mL	23.1820 mL
5 mM	0.4636 mL	2.3182 mL	4.6364 mL
10 mM	0.2318 mL	1.1591 mL	2.3182 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.92% ee.: 100%

Select Batch:

Data Sheet (268 KB) SDS (252 KB)

COA (244 KB) HNMR (253 KB) NP-HPLC (228 KB) LCMS (122 KB)

Handling Instructions (2659 KB)

References

[1]. Chemin J, et al. De novo mutation screening in childhood-onset cerebellar atrophy identifies gain-of-function mutations in the CACNA1G calcium channel gene. Brain. 2018;141(7):1998-2013. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3182 mL	11.5910 mL	23.1820 mL	57.9549 mL
	5 mM	0.4636 mL	2.3182 mL	4.6364 mL	11.5910 mL
	10 mM	0.2318 mL	1.1591 mL	2.3182 mL	5.7955 mL
	15 mM	0.1545 mL	0.7727 mL	1.5455 mL	3.8637 mL
	20 mM	0.1159 mL	0.5795 mL	1.1591 mL	2.8977 mL
	25 mM	0.0927 mL	0.4636 mL	0.9273 mL	2.3182 mL
	30 mM	0.0773 mL	0.3864 mL	0.7727 mL	1.9318 mL
	40 mM	0.0580 mL	0.2898 mL	0.5795 mL	1.4489 mL
	50 mM	0.0464 mL	0.2318 mL	0.4636 mL	1.1591 mL

TTA-P2 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TTA-P21072018-68-8T-Type calcium channel inhibitorCalcium ChannelCa2+ channelsCa channelsT-Type calcium channelCNST-type currentscerebellar nuclear neuronsCav3.1 channelsneurology diseaseInhibitorinhibitorinhibit

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TTA-P2 (Synonyms: T-Type calcium channel inhibitor)

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Other Forms of TTA-P2:

TTA-P2 Related Antibodies

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Complete Stock Solution Preparation Table

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