Topoisomerase IIα-IN-8
Based on 1 Customer Validation
Topoisomerase IIα-IN-8 (compound 15) is a weak human DNA topoisomerase IIa (htIIa) inhibitor, with an IC50 of 462 ± 38.0 μM.
For research use only. We do not sell to patients.
- CAS No.: 1251578-67-2
- Formula: C15H15FN6O
- Molecular Weight:314.32
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
All Topoisomerase Isoforms
More
Biological Activity
Description
IC50 & Target
|
topoisomerase II alpha |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | GI50 |
>100 μM
Compound: 3l
|
Antiproliferative activity against human HEK293 cells after 72 hrs by MTS assay
Antiproliferative activity against human HEK293 cells after 72 hrs by MTS assay
|
[PMID: 29684894] |
| HT-29 | GI50 |
>100 μM
Compound: 3l
|
Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
Antiproliferative activity against human HT-29 cells after 72 hrs by MTS assay
|
[PMID: 29684894] |
Chemical Information
-
CAS No. 1251578-67-2
-
Appearance Powder
-
Molecular Weight 314.32
-
Formula C15H15FN6O
-
SMILES
FC1=CC=C(C=C1)NC2=NC3=C(N=CN3)C(N4CCOCC4)=N2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
-
Data Sheet (269 KB)
-
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)