TRPC5-IN-6
TRPC5-IN-6 (Compound 12) is an orally effective transient receptor potential (TRPC5) inhibitor with a IC50 value of 81 nM. TRPC5-IN-6 has good biosafety and low liver and kidney toxicity, and is expected to play an important role in the treatment of chronic kidney disease (CKD).
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 3047956-65-7
- Fòrmula: C18H16Cl2FN5O2
- Peso molecular:424.26
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
TRPC5 |
TRPC5-IN-6 (Compound 12) (30 μM, 24 h) shows low toxicity on liver cells and HK-2 kidney cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Hepatocyte, HK-2 cell
-
Concentration:3, 10, 30 μM
-
Incubation Time:24 h
-
Result:Didn’t affect cell growth on both primary cultured hepatocytes and HK-2 cells
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:male ICR mice[1].
-
Dosage:10 mL/kg
-
Administration:oral gavage (p.o.)
-
Result:Was well and rapidly absorbed and mainly distributed in the colon, kidney, and liver[1].
-
Animal Model:hypertensive renal injury rat model[1].
-
Dosage:5, 10 mg/kg
-
Administration:oral gavage (p.o.)
-
Result:Suppressed levels of urinary protein and urinary albumin to creatinine ratio (UACR) and attenuated the degree of podocyte injury [1].
-
Animal Model:C57 mice[1].
-
Dosage:10 mL/kg, the final dose is 500 mg/kg
-
Administration:oral gavage (p.o.)
-
Result:Didn't cause death or abnormal behavior in mice[1].
Chemical Information
-
No. CAS 3047956-65-7
-
Peso molecular 424.26
-
Fòrmula C18H16Cl2FN5O2
-
SMILES
O=C1C(Cl)=C(N2CCN3C(C2)=NC=C3C(C4=C(Cl)C=C(F)C=C4)OC)C=NN1
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TRPC5-IN-6 Related Classifications
HY-162584 Related Classifications
Powered by Bioz