TRPC5-IN-6
TRPC5-IN-6 (Compound 12) is an orally effective transient receptor potential (TRPC5) inhibitor with a IC50 value of 81 nM. TRPC5-IN-6 has good biosafety and low liver and kidney toxicity, and is expected to play an important role in the treatment of chronic kidney disease (CKD).
For research use only. We do not sell to patients.
- CAS No.: 3047956-65-7
- Formula: C18H16Cl2FN5O2
- Molecular Weight:424.26
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TRPC5 |
TRPC5-IN-6 (Compound 12) (30 μM, 24 h) shows low toxicity on liver cells and HK-2 kidney cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Hepatocyte, HK-2 cell
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Concentration:3, 10, 30 μM
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Incubation Time:24 h
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Result:Didn’t affect cell growth on both primary cultured hepatocytes and HK-2 cells
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:male ICR mice[1].
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Dosage:10 mL/kg
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Administration:oral gavage (p.o.)
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Result:Was well and rapidly absorbed and mainly distributed in the colon, kidney, and liver[1].
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Animal Model:hypertensive renal injury rat model[1].
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Dosage:5, 10 mg/kg
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Administration:oral gavage (p.o.)
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Result:Suppressed levels of urinary protein and urinary albumin to creatinine ratio (UACR) and attenuated the degree of podocyte injury [1].
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Animal Model:C57 mice[1].
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Dosage:10 mL/kg, the final dose is 500 mg/kg
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Administration:oral gavage (p.o.)
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Result:Didn't cause death or abnormal behavior in mice[1].
Chemical Information
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CAS No. 3047956-65-7
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Molecular Weight 424.26
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Formula C18H16Cl2FN5O2
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SMILES
O=C1C(Cl)=C(N2CCN3C(C2)=NC=C3C(C4=C(Cl)C=C(F)C=C4)OC)C=NN1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TRPC5-IN-6 Related Classifications
HY-162584 Related Classifications
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