IGF-1R Modulator

GPVGPS is a low-molecular-weight fish collagen peptide. GPVGPS upregulates the expression of vascular endothelial growth factor (VEGF), PCNA, hepatocyte growth factor, epidermal growth factor (EGF) , and insulin-like growth factor 1 (IGF-1), and downregulates the expression of negative regulatory proteins associated with hair health. GPVGPS inhibits MMP-1, MMP-2, and MMP-9, increases skin water content, reduces wrinkles, and improves oxidative stress status and pro-inflammatory cytokine levels. GPVGPS can be used in studies related to hair loss and UVB-induced skin photoaging.

SU-4313 is a potent protein tyrosine kinases (PTKs) modulator with IC₅₀s of 14.5 μM, 18.8 μM, 11 μM, 16.9 μM, 8.0 μM for PDGFR, FLK-1, EGFR, HER2 Kinase and IGF-1R, respectively. SU-4313 has the potential for modulating tyrosine kinase signal transduction in order to regulate abnormal cell proliferation.

IGF-1R modulator 1 (Example 5) is an IGF-1R modulator, with EC₅₀s of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), 0.39 μM (TrkB). IGF-1R modulator 1 can be used for research of diseases characterised by impaired signalling of neurotrophins and/or other trophic factors, such as Alzheimer's disease.