Unguinol
Unguinol is a depsidone originally isolated from A. unguis. It is an inhibitor of pyruvate phosphate dikinase (PPDK; IC50=42.3 μM). It inhibits the growth of plants utilizing C4, but not C3, carbon fixation. Unguinol also inhibits the growth of the bacteria S. aureus and V. harveyi (GI50s=8.7 and 69.5 μM, respectively) and H460, MCF-7, and SF-268 cancer cells (GI50s=28.2, 50.8, and 44.3 μM, respectively).
For research use only. We do not sell to patients.
- CAS No.: 36587-59-4
- Formula: C19H18O5
- Molecular Weight:326.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | IC50 |
4.6 μg/mL
Compound: 8
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Cytotoxicity against African green monkey Vero cells by colorimetric assay
Cytotoxicity against African green monkey Vero cells by colorimetric assay
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[PMID: 33861594] |
Chemical Information
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CAS No. 36587-59-4
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Molecular Weight 326.34
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Formula C19H18O5
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SMILES
CC1=C2C(OC3=C(C(O2)=O)C(C)=CC(O)=C3)=C(C=C1O)/C(C)=C/C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Unguinol Related Classifications
HY-124456 Related Classifications
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