IK - IK cytokine Gene

Also Known as RED; RER; CSA2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3550

About IK

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:140,647,829-140,662,480 (from NCBI)

This gene has 10 transcripts (splice variants), 191 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 59.6), bone marrow (RPKM 39.1) and 25 other tissues.

Summary

The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2. [provided by RefSeq, Jul 2008]

IK Products (1)

mRNA Protein Name
NM_006083.4 NP_006074.2 protein Red

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
22365833 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22190034 GOA
Biological Process GO Annotation Evidence References Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
involved in mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
24252166 GOA
involved in mitotic spindle assembly checkpoint signaling IMP
IMP: Inferred from mutant phenotype
22351768 GOA
involved in protein localization to kinetochore IMP
IMP: Inferred from mutant phenotype
22351768 GOA
Cellular Component GO Annotation Evidence References Source
part of U2-type precatalytic spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
colocalizes with mitotic spindle pole IDA
IDA: Inferred from direct assay
22351768 GOA
colocalizes with nuclear chromosome IMP
IMP: Inferred from mutant phenotype
24252166 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
24252166 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28781166 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IK Protein Structure

RED_N

RED_N: RED-like protein N-terminal region (76 - 303)

RED_C

RED_C: RED-like protein C-terminal region (445 - 557)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 557 a.a.
Protein Preferred Names Protein Names

protein Red

  • IK cytokine, down-regulator of HLA II

IK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IK Q13123 MFAP1 Homo sapiens P55081
Y2H
22365833
Intra
IK Q13123 MFAP1 Homo sapiens P55081
Anti Tag CoIP
22365833
Intra
IK Q13123 DNAJB6 Homo sapiens O75190
Y2H Array
32814053
Intra
IK Q13123 DNAJB6 Homo sapiens O75190
Validated Y2H
32814053
Intra
IK Q13123 DNAJB6 Homo sapiens O75190
Y2H Pooling
32814053
Intra
IK Q13123 EGLN3 Homo sapiens Q9H6Z9
Validated Y2H
32296183
Intra
IK Q13123 RNF113A Homo sapiens O15541
Y2H
22365833
Intra
IK Q13123 RNF113A Homo sapiens O15541
Anti Tag CoIP
22365833
Intra
IK Q13123 XAB2 Homo sapiens Q9HCS7
Anti Tag CoIP
22365833
Intra
IK Q13123 SMU1 Homo sapiens Q2TAY7
Y2H Prey Pooling
32296183
Intra
IK Q13123 SMU1 Homo sapiens Q2TAY7
Y2H
22365833
Intra
IK Q13123 SMU1 Homo sapiens Q2TAY7
Validated Y2H
32296183
Intra
IK Q13123 SMU1 Homo sapiens Q2TAY7
Y2H Array
32296183
Intra
IK Q13123 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
IK Q13123 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
IK Q13123 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
IK Q13123 PRPF6 Homo sapiens O94906
Y2H
22365833
Intra
IK Q13123 PRPF6 Homo sapiens O94906
Anti Tag CoIP
22365833
Intra
IK Q13123 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
25416956
Intra
IK Q13123 RBM10 Homo sapiens P98175
Y2H
22365833
Intra
IK Q13123 RBM10 Homo sapiens P98175
Anti Tag CoIP
22365833
Intra
IK Q13123 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
Intra
IK Q13123 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
Intra
IK Q13123 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
Intra
IK Q13123 SNIP1 Homo sapiens Q8TAD8
Anti Tag CoIP
22365833
Intra
IK Q13123 SNIP1 Homo sapiens Q8TAD8
Y2H
22365833
Intra
IK Q13123 DR1 Homo sapiens Q01658
Y2H Array
32814053
Intra
IK Q13123 DR1 Homo sapiens Q01658
Validated Y2H
32814053
Intra
IK Q13123 DR1 Homo sapiens Q01658
Y2H Pooling
32814053
Cross
IK Q13123 rev Human immunodeficiency virus P04618
Pull Down
22190034
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Skin Amelanotic Melanoma

  • Skin Amelanotic Malignant Melanoma

  • Amelanotic Skin Melanoma
Influenza

  • Flu

  • Influenza With Non-Respiratory Manifestation

  • Influenza With Other Manifestations

  • Influenza, Human

  • Influenza, Susceptibility To

  • Seasonal Influenza, Virus Identified
Overhydrated Hereditary Stomatocytosis

  • Ohs

  • Potassium Sodium Disorder Of Erythrocyte

  • OHST

  • Stomatocytosis I

  • Potassium-Sodium Disorder Of Erythrocyte

  • Stomatocytosisiohst

  • Hereditary, Overhydrated, Cation-Leak Stomatocytosis

  • Overhydrated Cation Leak Stomatocytosis

  • Stomatocytosis, Overhydrated Hereditary
Chronic Atrial And Intestinal Dysrhythmia

  • CAID

  • Caid Syndrome

  • Cohesinopathy Affecting Heart And Gut Rhythm

  • Chronic Atrial Intestinal Dysrhythmia Syndrome

  • Chronic Atrial And Intestinal Dysrhythmia Syndrome

  • Chronic Atrial Dysrhythmia-Intestinal Motility Disorder

  • Dysrhythmia, Atrial And Intestinal, Chronic
Gordon Holmes Syndrome

  • Cerebellar Ataxia And Hypogonadotropic Hypogonadism

  • Lhrh Deficiency And Ataxia

  • Cerebellar Ataxia-Hypogonadism Syndrome

  • GDHS

  • Cahh

  • Luteinizing Hormone-Releasing Hormone Deficiency With Ataxia

  • Gordon-Holmes Syndrome

  • Deficiency Of Luteinizing Hormone-Releasing Hormone With Ataxia

  • Luteinizing Hormone-Releasing Hormone, Deficiency Of, With Ataxia

  • Cerebellar Ataxia - Hypogonadism

  • Luteinizing Hormone Releasing Hormone, Deficiency Of With Ataxia

  • Ataxia, Cerebellar, And Hypogonadotropic Hypogonadism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1751 Quinidine (15% dihydroquinidine) 98.36% Unkown
HY-B1302 Quinidine hydrochloride monohydrate 99.97% Yes
HY-100795A Pirmenol hydrochloride Inhibitor 99.34% Unkown
HY-100795 Pirmenol Inhibitor 99.32% Unkown
HY-B1751A Quinidine sulfate / Unkown
HY-B1751E Quinidine polygalacturonate / Unkown
HY-B1751F Quinidine gluconic acid / Unkown
HY-B1751D Quinidine sulfate dihydrate / Unkown

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-126704 Tedisamil / Phase 3
HY-153585 IK-930 Inhibitor 99.39% Phase 1
HY-118387 AVE-0118 Inhibitor 98.93% Phase 1
HY-118148 UK-66914 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15416 NS309 Activator 99.09% Unkown
HY-141609 IK-175 Inhibitor 99.89% Unkown
HY-181067 IK-595 Inhibitor 98.55% Unkown
HY-112544 IK1 inhibitor PA-6 Inhibitor 99.29% Unkown
HY-101253 AM-92016 hydrochloride 99.28% Unkown
HY-113841 RS-87337 Inhibitor / Unkown
HY-120059 NS4591 / Unkown
HY-120685 WAY-125971 Antagonist / Unkown
HY-126704A Tedisamil dihydrochloride Inhibitor / Unkown
HY-130070 QO-40 Activator 98.77% Unkown
HY-136805 Kv1.5-IN-1 Inhibitor / Unkown
HY-146365 HIV-1 inhibitor-30 Inhibitor / Unkown
HY-B1751S1 Quinidine-13C, d2 hydrochloride / Unkown
HY-RS06656 IK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07172 KCNN4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W115674 Quinidine hydrochloride / Unkown
HY-118734 IK-862 Inhibitor / Unkown
HY-RS16766 Ik Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23206 Ik Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990165 Anti-Mouse RANKL/CD254 Antibody (IK22/5) Inhibitor 99.37% Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus IK VGNC VGNC:30100
Felis catus IK VGNC VGNC:67750
Mus musculus IK MGD MGI:1345142
Canis familiaris IK VGNC VGNC:54958
Rattus norvegicus IK RGD RGD:1359352
Macaca mulatta IK VGNC VGNC:73703
Others IK NCBI