2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. VPC-18005

VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, and disrupts the ERG binding to DNA. VPC-18005 is a potent inhibitor of luciferase activity.

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VPC-18005

VPC-18005 構造式

CAS 番号 : 2242480-48-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 330 在庫あり
Solution
10 mM * 1 mL in DMSO USD 330 在庫あり
Solid
5 mg $300 在庫あり
10 mg $480 在庫あり
25 mg $950 在庫あり
50 mg $1450 在庫あり
100 mg $2100 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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VPC-18005 関連抗体

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DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示:

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RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

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製品説明

VPC-18005 inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, and disrupts the ERG binding to DNA. VPC-18005 is a potent inhibitor of luciferase activity[1].
体外実験

VPC-18005 is found to inhibit pETS-luc reporter activity in PNT1B-ERG and VCaP cells with IC50 values of 3 and 6 μM, respectively[1].
VPC-18005 could suppress ERG reporter activity without exhibiting overt cytotoxicity[1].
VPC-18005 inhibits migration and invasion of ERG-overexpressing cells in vitro[1].
VPC-18005 can antagonize the metastatic potential of ERG-expressing prostate cells[1].
The exposure of larvae to 1 or 10 μM of VPC-18005 produced a 20–30% decrease in the dissemination of cancer cells in zebrafsh[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VPC-18005 関連抗体

Cell Viability Assay[1]

Cell Line: PNT1B-Mock cells and PNT1B-ERG cells.
Concentration: 5 µM.
Incubation Time: 24 h.
Result: Inhibited migration and invasion of prostate cell lines in vitro.
分子量

319.38

分子式

C15H17N3O3S
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CC(S/C(N1)=N\N=C/C2=CC=C(C(C)C)C=C2)C1=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 62.5 mg/mL (195.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1311 mL 15.6553 mL 31.3107 mL
5 mM 0.6262 mL 3.1311 mL 6.2621 mL
10 mM 0.3131 mL 1.5655 mL 3.1311 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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純度とドキュメンテーション

純度: 99.80%

COA (252 KB) HNMR (251 KB) LCMS (93 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1311 mL 15.6553 mL 31.3107 mL 78.2767 mL
5 mM 0.6262 mL 3.1311 mL 6.2621 mL 15.6553 mL
10 mM 0.3131 mL 1.5655 mL 3.1311 mL 7.8277 mL
15 mM 0.2087 mL 1.0437 mL 2.0874 mL 5.2184 mL
20 mM 0.1566 mL 0.7828 mL 1.5655 mL 3.9138 mL
25 mM 0.1252 mL 0.6262 mL 1.2524 mL 3.1311 mL
30 mM 0.1044 mL 0.5218 mL 1.0437 mL 2.6092 mL
40 mM 0.0783 mL 0.3914 mL 0.7828 mL 1.9569 mL
50 mM 0.0626 mL 0.3131 mL 0.6262 mL 1.5655 mL
60 mM 0.0522 mL 0.2609 mL 0.5218 mL 1.3046 mL
80 mM 0.0391 mL 0.1957 mL 0.3914 mL 0.9785 mL
100 mM 0.0313 mL 0.1566 mL 0.3131 mL 0.7828 mL
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VPC-18005 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VPC-180052242480-48-2VPC18005VPC 18005DNA/RNA SynthesisprostatecancerETSERGPNT1BInhibitorinhibitorinhibit

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製品名:
VPC-18005
製品番号:
HY-122234
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