XR11576 (Synonyms: MLN576)

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XR11576 (MLN576) is an orally active inhibitor of topoisomerase I and II. XR11576 shows cytotoxicity against human and murine tumor cell lines (IC₅₀: 6-47 nM).

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XR11576 화학구조

CAS No. : 346689-77-8

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Biological Activity
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References
고객리뷰

제품 설명

XR11576 (MLN576) is an orally active inhibitor of topoisomerase I and II. XR11576 shows cytotoxicity against human and murine tumor cell lines (IC₅₀: 6-47 nM)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
COR-L23	IC₅₀	10.1 nM Compound: XR-11576	Cytotoxicity measured using the COR-L23 parental (COR-L23/P) human non small cell lung carcinoma cell line Cytotoxicity measured using the COR-L23 parental (COR-L23/P) human non small cell lung carcinoma cell line	[PMID: 11806724]
COR-L23	IC₅₀	12.1 nM Compound: XR-11576	Cytotoxicity measured with the drug resistant human non small cell lung carcinoma cell line COR-L23 (COR-L23/R) which over expresses multidrug resistance associated with protein(MRP) Cytotoxicity measured with the drug resistant human non small cell lung carcinoma cell line COR-L23 (COR-L23/R) which over expresses multidrug resistance associated with protein(MRP)	[PMID: 11806724]
NCI-H69	IC₅₀	1.2 nM Compound: 11	Inhibitory activity against drug resistant H69/LX4 line overexpressing P-glycoprotein Inhibitory activity against drug resistant H69/LX4 line overexpressing P-glycoprotein	[PMID: 11806725]
NCI-H69	IC₅₀	23 nM Compound: XR-11576	Cytotoxicity measured using the H69 parental (H69/P) human small cell lung carcinoma cell line Cytotoxicity measured using the H69 parental (H69/P) human small cell lung carcinoma cell line	[PMID: 11806724]
NCI-H69	IC₅₀	23 nM Compound: 11	Inhibitory activity against parental human small cell lung carcinoma cell line (H69P) Inhibitory activity against parental human small cell lung carcinoma cell line (H69P)	[PMID: 11806725]
NCI-H69	IC₅₀	29 nM Compound: XR-11576	Cytotoxicity measured using the drug resistant, P-glycoprotein (Pgp) expressing human small cell lung carcinoma cell line H69/LX4 Cytotoxicity measured using the drug resistant, P-glycoprotein (Pgp) expressing human small cell lung carcinoma cell line H69/LX4	[PMID: 11806724]
P388	IC₅₀	10 nM Compound: 11	Inhibitory activity against murine P388 leukemia (P388) cells. Inhibitory activity against murine P388 leukemia (P388) cells.	[PMID: 11806725]

분자량

388.46

화학식

C₂₃H₂₄N₄O₂

CAS No.

346689-77-8

SMILES

O=C(N[C@@H](CN(C)C)C)C1=C2C(N=C3C=CC4=C(C=CC=C4C3=N2)OC)=CC=C1

선적

Room temperature in continental US; may vary elsewhere.

보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Di Nicolantonio F, et al. Ex vivo characterization of XR11576 (MLN576) against ovarian cancer and other solid tumors. Anticancer Drugs. 2004 Oct;15(9):849-60. [Content Brief]

[2]. Mistry P, et al. In vitro and in vivo characterization of XR11576, a novel, orally active, dual inhibitor of topoisomerase I and II. Anticancer Drugs. 2002 Jan;13(1):15-28. [Content Brief]

XR11576 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XR11576346689-77-8MLN576XR 11576XR-11576MLN 576MLN-576TopoisomeraseanticancerMDRlung cancerMC26HT29colon carcinoma,Inhibitorinhibitorinhibit

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XR11576 (Synonyms: MLN576)

XR11576 Related Antibodies

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Biological Activity

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References

고객리뷰

XR11576 Related Classifications

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