2. Metabolic Enzyme/Protease
  3. Glucosidase Carbonic Anhydrase
  4. α-Glucosidase-IN-63

α-Glucosidase-IN-63 (Compound 4d) is an inhibitor of α-Glucosidase (IC50=0.44 μM). α-Glucosidase-IN-63 inhibits hCA II with an activity of Ki= 7.0 nM. α-Glucosidase-IN-63 is orally effective..

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α-Glucosidase-IN-63 Chemical Structure

α-Glucosidase-IN-63 Chemical Structure

CAS No. : 2375866-82-1

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α-Glucosidase-IN-63 Related Antibodies

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Description

α-Glucosidase-IN-63 (Compound 4d) is an inhibitor of α-Glucosidase (IC50=0.44 μM). α-Glucosidase-IN-63 inhibits hCA II with an activity of Ki= 7.0 nM. α-Glucosidase-IN-63 is orally effective.[1].

IC50 & Target[1]

hCA II

7.0 nM (Ki)

hCA IX

64.1 nM (Ki)

hCA XII

19.9 nM (Ki)

In Vitro

α-Glucosidase-IN-63 exhibits inhibitory abilities against human carbonic anhydrase (hCA) with Ki values of 7.0 nM (hCA II), 19.9 nM (hCA XII), and 64.1 nM (hCA IX)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Glucosidase-IN-63 Related Antibodies
In Vivo

α-Glucosidase-IN-63 (p.o.) shows significant hypoglycemic effect in Streptozocin (HY-13753)-induced diabetic mice, with significant recovery of glucose tolerance, and is superior to standard drug Acarbose (HY-B0089)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

377.41

Formula

C16H12FN3O3S2
CAS No.
Unlabeled CAS

SMILES

O=S(C1=CC=C(/N=C(NC/2=O)/SC2=C\C3=CC=C(F)C=C3)C=C1)(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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α-Glucosidase-IN-63 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Glucosidase-IN-632375866-82-1GlucosidaseCarbonic AnhydraseCarbonate dehydrataseThiazolidinoneBenzenesulfonamideCarbonic anhydraseType II diabetes mellitusStreptozocin diabetes modelInhibitorinhibitorinhibit

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