α-Hydroxyglutaric acid-13C5 disodium
Based on 1 Customer Validation
α-Hydroxyglutaric acid-13C5 (sodium) is the 13C labeled α-Hydroxyglutaric acid sodium. α-Hydroxyglutaric acid (2-Hydroxyglutarate) sodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid sodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.
For research use only. We do not sell to patients.
- Purity: 99.80%
- CAS No.: 2482467-23-0
- Formula: 13C5H6Na2O5
- Molecular Weight:197.04
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2482467-23-0
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Unlabeled Cas 40951-21-1
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Appearance Solid
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Molecular Weight 197.04
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Formula 13C5H6Na2O5
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Color White to off-white
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SMILES
O=[13C](O[Na])[13CH2][13CH2][13CH](O)[13C](O[Na])=O
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Synonyms
2-Hydroxyglutarate-13C5 disodium; 2-Hydroxyglutaric acid-13C5 disodium; 2-Hydroxypentanedioic acid-13C5 disodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H2O : 125 mg/mL (634.39 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Wei Xu, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19(1):17-30. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.0751 mL | 25.3756 mL | 50.7511 mL | 126.8778 mL |
| 5 mM | 1.0150 mL | 5.0751 mL | 10.1502 mL | 25.3756 mL | |
| 10 mM | 0.5075 mL | 2.5376 mL | 5.0751 mL | 12.6878 mL | |
| 15 mM | 0.3383 mL | 1.6917 mL | 3.3834 mL | 8.4585 mL | |
| 20 mM | 0.2538 mL | 1.2688 mL | 2.5376 mL | 6.3439 mL | |
| 25 mM | 0.2030 mL | 1.0150 mL | 2.0300 mL | 5.0751 mL | |
| 30 mM | 0.1692 mL | 0.8459 mL | 1.6917 mL | 4.2293 mL | |
| 40 mM | 0.1269 mL | 0.6344 mL | 1.2688 mL | 3.1719 mL | |
| 50 mM | 0.1015 mL | 0.5075 mL | 1.0150 mL | 2.5376 mL | |
| 60 mM | 0.0846 mL | 0.4229 mL | 0.8459 mL | 2.1146 mL | |
| 80 mM | 0.0634 mL | 0.3172 mL | 0.6344 mL | 1.5860 mL | |
| 100 mM | 0.0508 mL | 0.2538 mL | 0.5075 mL | 1.2688 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
α-Hydroxyglutaric acid-13C5 disodium Related Classifications
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