α-Hydroxyglutaric acid-d4 disodium
Based on 1 Customer Validation
α-Hydroxyglutaric acid-d4 (disodium) is the deuterium labeled α-Hydroxyglutaric acid disodium. α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases.
For research use only. We do not sell to patients.
- Purity: 99.77%
- CAS No.: 2483831-91-8
- Formula: C5H2D4Na2O5
- Molecular Weight:196.10
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 2483831-91-8
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Unlabeled Cas 40951-21-1
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Appearance Solid
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Molecular Weight 196.10
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Formula C5H2D4Na2O5
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Color Off-white to light yellow
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SMILES
O=C(O[Na])CC([2H])([2H])C(O[2H])([2H])C(O[Na])=O
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Synonyms
2-Hydroxyglutarate-d4 disodium; 2-Hydroxyglutaric acid-d4 disodium; 2-Hydroxypentanedioic acid-d4 disodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 125 mg/mL (637.43 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Wei Xu, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19(1):17-30. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 5.0994 mL | 25.4972 mL | 50.9944 mL | 127.4860 mL |
| 5 mM | 1.0199 mL | 5.0994 mL | 10.1989 mL | 25.4972 mL | |
| 10 mM | 0.5099 mL | 2.5497 mL | 5.0994 mL | 12.7486 mL | |
| 15 mM | 0.3400 mL | 1.6998 mL | 3.3996 mL | 8.4991 mL | |
| 20 mM | 0.2550 mL | 1.2749 mL | 2.5497 mL | 6.3743 mL | |
| 25 mM | 0.2040 mL | 1.0199 mL | 2.0398 mL | 5.0994 mL | |
| 30 mM | 0.1700 mL | 0.8499 mL | 1.6998 mL | 4.2495 mL | |
| 40 mM | 0.1275 mL | 0.6374 mL | 1.2749 mL | 3.1871 mL | |
| 50 mM | 0.1020 mL | 0.5099 mL | 1.0199 mL | 2.5497 mL | |
| 60 mM | 0.0850 mL | 0.4250 mL | 0.8499 mL | 2.1248 mL | |
| 80 mM | 0.0637 mL | 0.3187 mL | 0.6374 mL | 1.5936 mL | |
| 100 mM | 0.0510 mL | 0.2550 mL | 0.5099 mL | 1.2749 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
α-Hydroxyglutaric acid-d4 disodium Related Classifications
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